protein

C-JUN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C-JUN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

736Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

C-JUN is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 470 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	C-JUN
Molecular Weight	39 kDa
Amino Acids	331 aa
Pathways	Apoptosis, Nf-Κb, Toll-Like Receptor, Mapk, Invasion
GeneCards	C-JUN
Human Protein Atlas	C-JUN
Associated Diseases	Als, Cancer, Encephalitis, Infection, Multiple Sclerosis
Interactions	AGING, AHR, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	731 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    CJUN["C-JUN
Transcription Factor"]
    
    %% Upstream signaling
    JNK["JNK
Stress Kinase"]
    STRESS["Cellular Stress
Oxidative/ER Stress"]
    
    %% Pathways activated by C-JUN
    APOPTOSIS["Apoptosis
Pathway"]
    ER_STRESS["ER Stress
Response"]
    BIP["BiP/GRP78
ER Chaperone"]
    
    %% Inhibited pathways
    AKT["AKT
Survival Kinase"]
    PI3K["PI3K/AKT
Survival Pathway"]
    
    %% Neuroinflammation
    NEUROINFLAM["Neuroinflammation"]
    INFLAMMATION["Systemic
Inflammation"]
    
    %% Neurodegenerative diseases
    ALS["Amyotrophic
Lateral Sclerosis"]
    PD["Parkinson's
Disease"]
    MS["Multiple
Sclerosis"]
    EPILEPSY["Epilepsy"]
    
    %% Cellular outcomes
    CELL_DEATH["Neuronal
Cell Death"]
    NEUROPROT["Neuroprotection
(Context-dependent)"]
    
    %% Connections
    STRESS -->|"activates"| JNK
    JNK -->|"phosphorylates"| CJUN
    
    CJUN -->|"activates"| APOPTOSIS
    CJUN -->|"activates"| ER_STRESS
    CJUN -->|"activates"| BIP
    CJUN -->|"inhibits"| AKT
    CJUN -->|"inhibits"| PI3K
    
    CJUN -->|"promotes"| NEUROINFLAM
    CJUN -->|"activates"| INFLAMMATION
    
    CJUN -->|"dual role"| ALS
    CJUN -->|"contributes"| PD
    CJUN -->|"promotes"| MS
    CJUN -->|"triggers"| EPILEPSY
    
    APOPTOSIS -->|"leads to"| CELL_DEATH
    ER_STRESS -->|"can promote"| CELL_DEATH
    AKT -->|"blocked"| NEUROPROT
    
    NEUROINFLAM -->|"exacerbates"| ALS
    NEUROINFLAM -->|"worsens"| PD
    
    %% Styling
    style CJUN fill:#006494
    style APOPTOSIS fill:#ef5350
    style ER_STRESS fill:#ef5350
    style NEUROINFLAM fill:#ef5350
    style INFLAMMATION fill:#ef5350
    style CELL_DEATH fill:#5d4400
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style MS fill:#5d4400
    style EPILEPSY fill:#5d4400
    style BIP fill:#1b5e20
    style NEUROPROT fill:#1b5e20
    style JNK fill:#4a1a6b
    style AKT fill:#4a1a6b
    style PI3K fill:#4a1a6b

Outgoing (501)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:C-JUN	data_in	dataset_row	0.00
Apoptosis	activates	pathway	1.00
JUN	activates	gene	1.00
JNK	activates	gene	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
JUN	regulates	gene	1.00
APOPTOSIS	activates	gene	1.00
Inflammation	regulates	disease	0.95
hemocyanin	regulates	protein	0.90
JUN	associated_with	gene	0.90
GENES	activates	gene	0.90
JUN	inhibits	gene	0.90
Neuroinflammation	activates	disease	0.85
Parkinson	activates	disease	0.85
Ischemia	activates	disease	0.85
Neurodegeneration	activates	disease	0.85
Cancer	inhibits	disease	0.85
JNK	associated_with	gene	0.80
PI3K	activates	gene	0.80
Oxidative Stress	activates	pathway	0.80
Nf-Κb	activates	pathway	0.80
Toll-Like Receptor	activates	pathway	0.80
Oxidative Stress	inhibits	pathway	0.80
NRF2	inhibits	gene	0.80
INFLAMMATION	activates	gene	0.80
APOPTOSIS	inhibits	gene	0.80
JNK	inhibits	gene	0.80
Apoptosis	inhibits	pathway	0.80
Mapk	inhibits	pathway	0.80
INFLAMMATION	regulates	gene	0.80
Cancer	therapeutic_target	disease	0.75
Atherosclerosis	activates	disease	0.75
Cancer	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Fibrosis	inhibits	disease	0.75
Cancer	expressed_in	disease	0.75
Als	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Breast Cancer	inhibits	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
Neurodegeneration	therapeutic_target	disease	0.75
ROS	activates	gene	0.70
JNK	therapeutic_target	gene	0.70
TLR4	activates	gene	0.70
SLC7A11	upregulates	gene	0.70
Apoptosis	therapeutic_target	pathway	0.70
PARKINSON	activates	gene	0.70

Incoming (235)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:C-JUN	data_in	dataset_row	0.00
DLK	phosphorylates	gene	0.90
JUN	activates	gene	0.90
BCL-2	activates	gene	0.80
ERK1	activates	gene	0.80
CYTOKINES	activates	gene	0.80
ROS	activates	gene	0.80
TNF	activates	gene	0.80
BAX	activates	gene	0.80
GFAP	activates	gene	0.80
NRF2	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
TNF-Α	activates	gene	0.70
CREB	activates	gene	0.70
HO-1	activates	gene	0.70
P38	activates	gene	0.70
TLR4	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
NF-ΚB	activates	gene	0.70
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
P38	contributes_to	gene	0.60
CXCL8	activates	gene	0.60
ERK	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
AHR	inhibits	gene	0.60
P38	inhibits	gene	0.60
P53	activates	gene	0.60
FLAVONOIDS	inhibits	gene	0.60
FOS	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
JUN	inhibits	gene	0.60
DRP1	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
RAC1	activates	gene	0.60
CANCER	activates	gene	0.60
GPX4	inhibits	gene	0.60
INFLAMMATORY GENES	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
DLK	activates	gene	0.60
RELB	regulates	gene	0.60
STAT1	regulates	gene	0.60
C-FOS	inhibits	gene	0.60
NLRP3	activates	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
SHH	therapeutic_target	gene	0.60
JNK2	activates	gene	0.60
JNK1	activates	gene	0.60
PI3K	activates	gene	0.60
ESR1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity