gene

USP7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

157Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

USP7 is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, activates. Associated with ALS, Als, Cancer. Connected to 76 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	USP7
Full Name	Ubiquitin-Specific Peptidase 7
Aliases	HAUSP Deubiquitinase
Chromosome	16p13.2
Protein Type	Enzyme
Function	encodes a deubiquitinating enzyme (DUB) that removes ubiquitin from target proteins, regulating their stability and function.
Molecular Weight	128 kDa
Amino Acids	102 aa
Pathways	NF-κB, Wnt signaling
UniProt ID	Q93009
NCBI Gene ID	7874
Ensembl ID	ENSG00000187555
OMIM	602519
GeneCards	USP7
Human Protein Atlas	USP7
Associated Diseases	Als, Cancer, glioblastoma, Huntington's disease
Known Drugs/Compounds	H2O2
Interactions	ALOX15, AMBRA1, AND, AR, ATM, CANCER
KG Connections	157 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: USP7 — AlphaFold Q93009 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

USP7 Gene

gene · 898 words

→

USP7 Protein (HAUSP Deubiquitinase)

protein · 922 words

→

Pathway Diagram

graph TD
    USP7["USP7"]
    UBA52["UBA52"]
    USP7 -->|"modifies"| UBA52
    AMBRA1["AMBRA1"]
    USP7 -->|"modifies"| AMBRA1
    UBIQUITINATION(["UBIQUITINATION"])
    USP7 -->|"regulates"| UBIQUITINATION
    Cancer{"Cancer"}
    USP7 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    USP7 -->|"inhibits"| Tumor
    Als{"Als"}
    USP7 -->|"associated with"| Als
    Ms{"Ms"}
    USP7 -->|"therapeutic target"| Ms
    USP7 -->|"therapeutic target"| Als
    USP7 -->|"activates"| Tumor
    USP7 -->|"expressed in"| Ms
    USP7 -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    USP7 -->|"regulates"| Inflammation
    MLKL["MLKL"]
    MLKL -->|"regulates"| USP7
    H2O2["H2O2"]
    H2O2 -->|"activates"| USP7
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"inhibits"| USP7
    GENES["GENES"]
    GENES -->|"inhibits"| USP7
    MIRNAS["MIRNAS"]
    MIRNAS -->|"inhibits"| USP7
    ALOX15["ALOX15"]
    ALOX15 -->|"inhibits"| USP7
    MIRNAS -->|"activates"| USP7
    CANCER["CANCER"]
    CANCER -->|"activates"| USP7
    LC3B["LC3B"]
    LC3B -->|"expressed in"| USP7
    YY1["YY1"]
    YY1 -->|"interacts with"| USP7
    ROS["ROS"]
    ROS -->|"inhibits"| USP7
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"inhibits"| USP7
    style USP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
Autophagy	involved_in	process	0.95
UBA52	modifies	gene	0.90
Ubiquitinated proteins	deubiquitinates	compound	0.90
AMBRA1	modifies	protein	0.90
Neural Stem Cell Maintenance	involved_in	process	0.85
UBA52	interacts_with	protein	0.85
neural stem cell maintenance	regulates	process	0.85
ubiquitin-proteasome	participates_in	pathway	0.80
Tumor	inhibits	disease	0.75
Cancer	associated_with	disease	0.75
miR-522	associated_with	compound	0.75
UBIQUITINATION	regulates	pathway	0.72
Ferroptosis	inhibits	pathway	0.70
Als	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	activates	disease	0.65
ALS	associated_with	disease	0.65
ALS	stabilizes	disease	0.65
Als	regulates	disease	0.65
PROTEIN_DEGRADATION	inhibits	pathway	0.64
UBIQUITIN	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Autophagy	regulates	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Metastasis	inhibits	pathway	0.60
Differentiation	activates	pathway	0.60
MIRNAS	inhibits	gene	0.60
GLIOBLASTOMA	regulates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
MTOR	regulates	gene	0.60
ERK1	regulates	gene	0.60
USP9X	associated_with	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
AMBRA1	activates	gene	0.60

Incoming (71)

Source	Relation	Type	Str
MLKL	interacts_with	protein	0.85
H2O2	activates	drug	0.80
MLKL	regulates	gene	0.80
UBIQUITIN	regulates	gene	0.70
FERROPTOSIS	inhibits	gene	0.70
CFTR	associated_with	gene	0.60
DNA	activates	gene	0.60
ERK1/2	regulates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
USP13	regulates	gene	0.60
AR	interacts_with	gene	0.60
SCA3	inhibits	gene	0.60
AR	associated_with	gene	0.60
AR	regulates	gene	0.60
HTT	interacts_with	gene	0.60
SCA3	implicated_in	gene	0.60
CANCER	activates	gene	0.60
LC3B	expressed_in	gene	0.60
ROS	inhibits	gene	0.60
FSP1	therapeutic_target	gene	0.60
TFR1	therapeutic_target	gene	0.60
PTEN	regulates	gene	0.60
OTUD3	regulates	gene	0.60
PI3K	regulates	gene	0.60
NRF2	activates	gene	0.60
MLKL	stabilizes	gene	0.60
UBIQUITIN	stabilizes	gene	0.60
INFLAMMATION	activates	gene	0.60
YY1	interacts_with	gene	0.60
GPX4	therapeutic_target	gene	0.60
MIRNAS	inhibits	gene	0.60
MIRNAS	activates	gene	0.60
GENES	inhibits	gene	0.60
AUTOPHAGY	stabilizes	gene	0.60
ubiquitination	regulates	process	0.60
ubiquitination	inhibits	process	0.60
ATM	activates	gene	0.60
FBXO7	regulates	gene	0.60
FBXO7	activates	gene	0.60
ROS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
UBA52	stabilizes	gene	0.60
ALOX15	inhibits	gene	0.60
STAT3	activates	gene	0.60
CD4	activates	gene	0.60
HNRNPA1	degrades	entity	0.60
UBIQUITIN	degrades	entity	0.60
ALOX15	activates	entity	0.60
HNRNPA1	activates	entity	0.60
ALOX15	associated_with	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning USP7 in their description or question text

No additional research found