gene

CDK6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

50Outgoing

15Incoming

0Experiments

0Debates

Summary

Cyclin-Dependent Kinase 6 - cell cycle and neurodegeneration

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CDK6
Aliases	Cyclin-Dependent Kinase 6
Protein Type	Serine/Threonine Kinase
Function	The CDK6 gene encodes Cyclin-Dependent Kinase 6, a 326-amino acid serine/threonine kinase
Primary Expression	gliomas, lymphomas, and carcinomas
Molecular Weight	37 kDa
Amino Acids	326 aa
Ensembl ID	ENSG00000105810
GeneCards	CDK6
Human Protein Atlas	CDK6
Cell Cycle G1/S Transition	Phosphorylates retinoblastoma protein (Rb), releasing E2F transcription factors to activate S-phase genes[@lim2013].
Cellular Differentiation	Regulates differentiation of various cell types including neurons, osteoblasts, and adipocytes.
Transcriptional Regulation	Controls gene expression through phosphorylation of transcription factors and chromatin modifiers.
DNA Damage Response	Involved in DNA damage checkpoints and repair.
Synaptic Plasticity	Regulates synaptic protein synthesis and dendritic spine morphology.
Associated Diseases	Als, Cancer, Carcinoma, Tumor
Interactions	AKT, AMBRA1, AND, AUTOPHAGY, AUTOPHAGY-RELATED GENES, CANCER
KG Connections	75 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDK6 Gene

gene · 537 words

→

CDK6 Protein

protein · 2710 words

→

Pathway Diagram

graph TD
    CDK6["CDK6"]
    Ms{"Ms"}
    CDK6 -->|"expressed in"| Ms
    CDK6 -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    CDK6 -->|"therapeutic target"| Cancer
    Carcinoma{"Carcinoma"}
    CDK6 -->|"associated with"| Carcinoma
    Als{"Als"}
    CDK6 -->|"associated with"| Als
    CDK6 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    CDK6 -->|"associated with"| Tumor
    GENES["GENES"]
    CDK6 -->|"expressed in"| GENES
    DNA["DNA"]
    CDK6 -->|"expressed in"| DNA
    PAX6["PAX6"]
    CDK6 -->|"regulates"| PAX6
    Cell_Cycle(["Cell Cycle"])
    CDK6 -->|"expressed in"| Cell_Cycle
    PRKCB["PRKCB"]
    CDK6 -->|"therapeutic target"| PRKCB
    AMBRA1["AMBRA1"]
    AMBRA1 -->|"inhibits"| CDK6
    PAX6 -->|"regulates"| CDK6
    MAPK3["MAPK3"]
    MAPK3 -->|"therapeutic target"| CDK6
    PIK3CA["PIK3CA"]
    PIK3CA -->|"inhibits"| CDK6
    DNA -->|"expressed in"| CDK6
    GENES -->|"expressed in"| CDK6
    AND["AND"]
    AND -->|"regulates"| CDK6
    style CDK6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (60)

Target	Relation	Type	Str
Tumor	associated_with	disease	0.85
Cancer	therapeutic_target	disease	0.75
CANCER	therapeutic_target	gene	0.70
CDK4	therapeutic_target	gene	0.70
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Autophagy	inhibits	pathway	0.60
senescence	participates_in	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
RNA	implicated_in	gene	0.60
AUTOPHAGY-RELATED GENES	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NRAS	associated_with	gene	0.60
PLCG1	associated_with	gene	0.60
TET2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
U2AF1	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
Mapk	therapeutic_target	pathway	0.60
Cell Division	therapeutic_target	pathway	0.60
Cell Cycle	therapeutic_target	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
RAB7A	inhibits	gene	0.60
AKT	inhibits	gene	0.60
TGFBR1	associated_with	gene	0.60
CDK4	inhibits	gene	0.60
CDK2	therapeutic_target	gene	0.60
CDK1	therapeutic_target	gene	0.60
PAX6	expressed_in	entity	0.60
Rb	regulates	protein	0.60
CDKN2A	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
NRF2	implicated_in	gene	0.60
TFE3	implicated_in	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
STAT3	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60

Incoming (15)

Source	Relation	Type	Str
NRF2	regulates	gene	0.90
AMBRA1	inhibits	protein	0.90
PAX6	regulates	gene	0.60
CDK4	activates	gene	0.60
LC3	inhibits	gene	0.60
CDK4	inhibits	gene	0.60
MAPK3	therapeutic_target	gene	0.60
ATM	associated_with	gene	0.60
AND	inhibits	gene	0.60
GENES	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
PIK3CA	inhibits	gene	0.60
DNA	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ATM	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDK6 in their description or question text

No additional research found