pathway

TGF-beta signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGF-beta signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

242Connections

1Hypotheses

0Analyses

25Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	TGF-beta signaling
Key Genes/Proteins	ABCC8, ACSL5, ACVR1, ADAMTS4, ADIPOQ, AKT
Related Diseases	aging, Alzheimer's disease
Related Pathways	AMPK signaling

Pathway Diagram

graph TD
    TGF_beta_signaling["TGF-beta signaling"] -.->|"inhibits"| Mgnd_Response["Mgnd Response"]
    style Mgnd_Response fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AMBRA1["AMBRA1"] -->|"activates"| TGF_beta_signaling["TGF-beta signaling"]
    style AMBRA1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"crosstalk with"| TGF_beta_signaling["TGF-beta signaling"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ITGB8["ITGB8"] -->|"activates"| TGF_beta_signaling["TGF-beta signaling"]
    style ITGB8 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    miRNA["miRNA"] -->|"regulates"| TGF_beta_signaling["TGF-beta signaling"]
    style miRNA fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    EGFR["EGFR"] -->|"participates in"| TGF_beta_signaling["TGF-beta signaling"]
    style EGFR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style TGF_beta_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (25)

Target	Relation	Type	Str
Mgnd Response	inhibits	process	0.91
neural stem cells	active_in	cell_type	0.90
microglia	active_in	cell_type	0.90
unfolded protein response	crosstalk_with	pathway	0.90
neurons	active_in	cell_type	0.90
macrophages	active_in	cell_type	0.80
SNCA	upregulates	gene	0.80
endothelial cells	active_in	cell_type	0.70
astrocytes	active_in	cell_type	0.70
hippocampus	active_in	brain_region	0.70
hypothalamus	active_in	brain_region	0.60
oligodendrocytes	active_in	cell_type	0.60
spinal cord	active_in	brain_region	0.60
white matter	active_in	brain_region	0.60
T cells	active_in	cell_type	0.60
epigenetic regulation	crosstalk_with	pathway	0.60
pericytes	active_in	cell_type	0.60
blood-brain barrier	active_in	brain_region	0.60
dopaminergic neurons	active_in	cell_type	0.60
thalamus	active_in	brain_region	0.60
lipid metabolism	crosstalk_with	pathway	0.60
mast cells	active_in	cell_type	0.60
Wnt signaling	crosstalk_with	pathway	0.60
ASTROCYTES	associated_with	cell_type	0.50
ASTROCYTE	associated_with	cell_type	0.50

Incoming (217)

Source	Relation	Type	Str
ITGB8	activates	gene	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
AMBRA1	activates	protein	0.90
SMAD2	component_of	protein	0.90
ALK5	component_of	protein	0.90
TGF	participates_in	gene	0.85
IL-10	participates_in	gene	0.85
DYNLRB1	component_of	protein	0.80
miRNA	regulates	biological_process	0.80
APP	participates_in	gene	0.80
SMAD3	participates_in	gene	0.80
RNA	participates_in	gene	0.80
JAK	participates_in	gene	0.80
Alzheimer's disease	involves	disease	0.80
EGFR	participates_in	gene	0.80
spinal muscular atrophy	involves	disease	0.80
JAK-STAT signaling	crosstalk_with	pathway	0.80
TNF	participates_in	gene	0.80
microglia	active_in	cell_type	0.75
IL-6	participates_in	gene	0.75
GDNF	participates_in	gene	0.75
SORL1	participates_in	gene	0.70
TET2	participates_in	gene	0.70
MAPK	participates_in	gene	0.70
APOE	participates_in	gene	0.70
aging	involves	disease	0.70
PI3K	participates_in	gene	0.70
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.70
Parkinson's disease	involves	disease	0.70
TGM2	participates_in	gene	0.70
PRKN	participates_in	gene	0.70
HMGB1	participates_in	gene	0.70
FGF	participates_in	gene	0.70
neurodegeneration	involves	disease	0.70
AQP1	participates_in	gene	0.70
SMAD2	participates_in	gene	0.70
ARG1	participates_in	gene	0.65
CREB	participates_in	gene	0.65
HDAC	participates_in	gene	0.65
astrocytes	active_in	cell_type	0.65
HIF	participates_in	gene	0.65
NOS3	participates_in	gene	0.60
WNT7B	participates_in	gene	0.60
KRAS	participates_in	gene	0.60
BMP2	participates_in	gene	0.60
HDAC5	participates_in	gene	0.60
NGF	participates_in	gene	0.60
SIRT1	participates_in	gene	0.60
AMPK	participates_in	gene	0.60
endosome	involved_in	organelle	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Early Postnatal TGF-beta Signaling Establishes Lifelong Regi	0.500	neuroinflammation	How do regional, age, and sex-dependent

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TGF-beta signaling in their description or question text

No additional research found