gene

FAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

602Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FAS is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with AD, ALS, AMI. Connected to 413 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FAS
Protein Family	TNF receptor superfamily
Protein Type	Receptor
Function	FAS (also known as CD95 or APO-1) is a cell surface receptor that triggers apoptosis upon binding with its ligand FASLG
Primary Expression	neurons and glial cells throughout the brain and plays roles in developmental apoptosis, immune surveillance, synaptic pruning, a
Subcellular Localization	Plasma membrane
Molecular Weight	43 kDa
Pathways	pathway: ### Activation Cascade
UniProt ID	P01375
GeneCards	FAS
Human Protein Atlas	FAS
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, AMI
Interactions	A2M, ACETYL-COA, AGING, AKT, ALS, ALZHEIMER
KG Connections	601 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FAS — AlphaFold P01375 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    FAS_gene["FAS
Gene"]
    FAS_protein["FAS
Protein"]
    FOXO["FOXO
Transcription Factor"]
    AMBRA1["AMBRA1
Autophagy Regulator"]
    
    apoptosis["Apoptosis
Cell Death"]
    neurodegeneration["Neurodegeneration
Disease Process"]
    neuroinflammation["Neuroinflammation
Immune Response"]
    
    alzheimer["Alzheimer's
Disease"]
    als["ALS
Disease"]
    ms["Multiple
Sclerosis"]
    
    TNF["TNF
Cytokine"]
    IL6["IL6
Cytokine"]
    APOE["APOE
Lipid Transport"]
    
    inflammation["Chronic
Inflammation"]
    aging["Cellular
Aging"]
    senescence["Cellular
Senescence"]
    
    FOXO -->|"activates"| FAS_gene
    AMBRA1 -->|"regulates"| FAS_protein
    FAS_gene -->|"encodes"| FAS_protein
    
    FAS_protein -->|"activates"| apoptosis
    FAS_gene -->|"activates"| neurodegeneration
    FAS_gene -->|"activates"| neuroinflammation
    
    FAS_gene -->|"activates"| alzheimer
    FAS_gene -->|"activates"| als
    FAS_gene -->|"activates"| ms
    
    FAS_gene -->|"activates"| TNF
    FAS_gene -->|"activates"| IL6
    FAS_gene -->|"interacts_with"| APOE
    
    FAS_gene -->|"regulates"| inflammation
    FAS_gene -->|"regulates"| aging
    FAS_gene -->|"regulates"| senescence
    
    apoptosis -->|"contributes_to"| neurodegeneration
    neuroinflammation -->|"promotes"| neurodegeneration
    
    style FAS_gene fill:#006494
    style FAS_protein fill:#006494
    style AMBRA1 fill:#4a1a6b
    style FOXO fill:#4a1a6b
    style apoptosis fill:#ef5350
    style neurodegeneration fill:#ef5350
    style neuroinflammation fill:#ef5350
    style alzheimer fill:#5d4400
    style als fill:#5d4400
    style ms fill:#5d4400
    style inflammation fill:#ef5350
    style aging fill:#ef5350
    style senescence fill:#ef5350
    style TNF fill:#ef5350
    style IL6 fill:#ef5350
    style APOE fill:#4a1a6b

Outgoing (428)

Target	Relation	Type	Str
apoptosis	activates	phenotype	0.90
Lipid Metabolism	activates	pathway	0.90
Als	therapeutic_target	disease	0.85
Apoptosis	associated_with	process	0.85
Als	inhibits	disease	0.85
APOPTOSIS	promotes	process	0.85
Als	regulates	disease	0.85
Inflammation	activates	disease	0.85
cell death	promotes	process	0.85
Tumor	therapeutic_target	disease	0.85
Neurodegeneration	activates	disease	0.85
Cancer	therapeutic_target	disease	0.85
dyslipidemia	drives	phenotype	0.82
Apoptosis	regulates	pathway	0.80
CANCER	therapeutic_target	gene	0.80
Apoptosis	activates	pathway	0.80
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Obesity	activates	disease	0.75
Diabetes	regulates	disease	0.75
Alzheimer	regulates	disease	0.75
Aging	activates	disease	0.75
Cancer	regulates	disease	0.75
Tumor	regulates	disease	0.75
Inflammation	inhibits	disease	0.75
Als	associated_with	disease	0.75
MITOCHONDRIA	activates	gene	0.70
BDNF	activates	gene	0.70
AKT	regulates	gene	0.70
MTOR	inhibits	gene	0.70
APOPTOSIS	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
GENES	regulates	gene	0.70
AKT	inhibits	gene	0.70
LC3	inhibits	gene	0.70
AKT	activates	gene	0.70
BCL-2	associated_with	gene	0.70
apoptosis	activates	process	0.70
LIPOPHAGY	inhibits	gene	0.70
Autophagy	inhibits	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
Mtor	inhibits	pathway	0.70
INFLAMMATION	inhibits	gene	0.70
Heart Failure	contributes_to	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Ischemia	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Cardiovascular	contributes_to	disease	0.65

Incoming (174)

Source	Relation	Type	Str
AMBRA1	regulates	protein	0.90
SREBP1C	upregulates	gene	0.87
FOXO	activates	protein	0.80
APOPTOSIS	regulates	gene	0.80
HSV-1	regulates	entity	0.75
P53	inhibits	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
APOPTOSIS	associated_with	gene	0.70
APOPTOSIS	activates	gene	0.70
ALZHEIMER	regulates	gene	0.70
BAX	inhibits	gene	0.70
BDNF	activates	gene	0.70
IL6	activates	gene	0.70
PI3K	regulates	gene	0.70
STAT3	activates	gene	0.70
NF-ΚB	inhibits	gene	0.70
CYTOKINES	inhibits	gene	0.70
OXIDATIVE STRESS	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
TLR	activates	gene	0.60
TCR	regulates	gene	0.60
IL-6	inhibits	gene	0.60
AUTOPHAGY	regulates	gene	0.60
DDB1	therapeutic_target	gene	0.60
CD36	expressed_in	gene	0.60
CAT	causes	gene	0.60
BAX	activates	gene	0.60
STAT1	activates	gene	0.60
PI3K	activates	gene	0.60
CANCER	regulates	gene	0.60
BCL-2	activates	gene	0.60
FASL	causes	gene	0.60
APOE	associated_with	gene	0.60
TNF	treats	gene	0.60
APOE4	associated_with	gene	0.60
P16INK4A	regulates	gene	0.60
IL6	regulates	gene	0.60
CHMP4B	associated_with	gene	0.60
CHMP4B	regulates	gene	0.60
P21CIP1	regulates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ASTROCYTE	associated_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AGING	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
CANCER	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Physiological SCFAs may confer indirect anti-synuclein benef	0.670	neurodegeneration	Do physiological concentrations of SCFAs
Physiological SCFAs may reduce alpha-synuclein burden primar	0.650	neurodegeneration	Do physiological concentrations of SCFAs
The most realistic translational use of physiological SCFAs	0.610	neurodegeneration	Do physiological concentrations of SCFAs
Physiological SCFAs may worsen alpha-synuclein pathology thr	0.550	neurodegeneration	Do physiological concentrations of SCFAs
Hippocampus ages transcriptionally faster than cerebellum, d	0.516	Alzheimer's disease	Allen Mouse Brain Aging Atlas: cross-age

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FAS in their description or question text

No additional research found

FAS

Understanding Entity Pages

Summary

Wiki Pages (8)

FAS Gene

FASN Protein

FASN Gene

FASLG - Fas Ligand

NFASC — Neurofascin

NFASC Protein

FASLG Protein - Fas Ligand

FAS Protein