Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about alzheimers-disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Diseases | Alzheimer's disease, Parkinson's disease, ALS, FTD, Huntington's disease, PSP, MSA |
| Brain regions | substantia nigra, striatum, motor cortex, hippocampus, frontal cortex |
| Cell types | dopaminergic neurons, astrocytes, microglia, motor neurons, oligodendrocytes |
| Proteins/Genes | tau, alpha-synuclein, TDP-43, SNCA, GBA, LRRK2, C9orf72, HTT |
| Therapeutics | gene therapy, ASOs, CRISPR gene editing, deep brain stimulation |
| Pathways | complement system, neurotrophic signaling, cell death pathways |
| KG Connections | 26 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
alzheimers_disease["alzheimers-disease"]
APOE["APOE"]
alzheimers_disease -->|"references"| APOE
GFAP["GFAP"]
alzheimers_disease -->|"references"| GFAP
TREM2["TREM2"]
alzheimers_disease -->|"references"| TREM2
style alzheimers_disease fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| entities-interleukin-6 | associated_with | wiki | 0.00 |
| entities-norepinephrine | associated_with | wiki | 0.00 |
| entities-complement-system | associated_with | wiki | 0.00 |
| entities-dna-methylation | associated_with | wiki | 0.00 |
| entities-snx5 | associated_with | wiki | 0.00 |
| entities-buntanetap | associated_with | wiki | 0.00 |
| entities-hsp90-protein | associated_with | wiki | 0.00 |
| entities-grm5-gene | associated_with | wiki | 0.00 |
| entities-prx005 | associated_with | wiki | 0.00 |
| entities-microglia-in-neurodegeneration | associated_with | wiki | 0.00 |
| entities-ampk | associated_with | wiki | 0.00 |
| entities-overview | associated_with | wiki | 0.00 |
| entities-pnt001 | associated_with | wiki | 0.00 |
| entities-semorinemab | associated_with | wiki | 0.00 |
| entities-fdg-pet | associated_with | wiki | 0.00 |
| entities-histone-deacetylase | associated_with | wiki | 0.00 |
| entities-glymphatic-system | associated_with | wiki | 0.00 |
| entities-gaba | associated_with | wiki | 0.00 |
| entities-aduhelm | associated_with | wiki | 0.00 |
| entities-simufilam | associated_with | wiki | 0.00 |
| entities-crenezumab | associated_with | wiki | 0.00 |
| entities-ferroptosis | associated_with | wiki | 0.00 |
| entities-biiib080 | associated_with | wiki | 0.00 |
| entities-al001 | associated_with | wiki | 0.00 |
| entities-irs1 | associated_with | wiki | 0.00 |
| entities-brain-health-roundtable-aadapt-act | associated_with | wiki | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity