protein

SMAD4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

201Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SMAD4 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with Als, Alzheimer, Cancer. Connected to 102 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SMAD4
Full Name	SMAD Family Member 4
Chromosome	18q21.1
Function	is a central mediator of TGF-beta signaling in the nervous system.
Molecular Weight	60 kDa
Amino Acids	552 aa
Pathways	TGF-β
UniProt ID	Q99707
NCBI Gene ID	4089
Ensembl ID	ENSG00000141646
OMIM	600993
GeneCards	SMAD4
Human Protein Atlas	SMAD4
MH1 domain (N-terminal)	Contains the DNA-binding domain that recognizes SMAD-binding elements (SBE) in target gene promoters
MH2 domain (C-terminal)	Mediates protein-protein interactions with R-SMADs, transcriptional co-activators, and co-repressors
Associated Diseases	Cancer
Interactions	ACSL4, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOPTOSIS
KG Connections	199 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMAD4 — AlphaFold Q99707 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SMAD4 — SMAD Family Member 4

gene · 866 words

→

SMAD4 Protein

protein · 736 words

→

Pathway Diagram

graph TD
    SMAD4["SMAD4"]
    mitophagy(["mitophagy"])
    SMAD4 -->|"regulates"| mitophagy
    Als{"Als"}
    SMAD4 -->|"activates"| Als
    Cancer{"Cancer"}
    SMAD4 -->|"activates"| Cancer
    Tumor{"Tumor"}
    SMAD4 -->|"expressed in"| Tumor
    Ms{"Ms"}
    SMAD4 -->|"activates"| Ms
    SMAD4 -->|"activates"| Tumor
    SMAD4 -->|"expressed in"| Ms
    SMAD2["SMAD2"]
    SMAD4 -->|"regulates"| SMAD2
    LC3["LC3"]
    SMAD4 -->|"activates"| LC3
    Mitophagy(["Mitophagy"])
    SMAD4 -->|"activates"| Mitophagy
    AUTOPHAGY["AUTOPHAGY"]
    SMAD4 -->|"activates"| AUTOPHAGY
    APOPTOSIS["APOPTOSIS"]
    SMAD4 -->|"activates"| APOPTOSIS
    BMPR1A["BMPR1A"]
    BMPR1A -->|"associated with"| SMAD4
    BNIP3["BNIP3"]
    BNIP3 -->|"activates"| SMAD4
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"activates"| SMAD4
    GENES["GENES"]
    GENES -->|"activates"| SMAD4
    TGFB1["TGFB1"]
    TGFB1 -->|"activates"| SMAD4
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"activates"| SMAD4
    SMAD3["SMAD3"]
    SMAD3 -->|"regulates"| SMAD4
    BNIP3L["BNIP3L"]
    BNIP3L -->|"activates"| SMAD4
    TP53["TP53"]
    TP53 -->|"activates"| SMAD4
    MYC["MYC"]
    MYC -->|"activates"| SMAD4
    P62["P62"]
    P62 -->|"activates"| SMAD4
    CANCER["CANCER"]
    CANCER -->|"activates"| SMAD4
    style SMAD4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (122)

Target	Relation	Type	Str
mitophagy	regulates	pathway	0.90
Tumor	inhibits	disease	0.75
Tumor	expressed_in	disease	0.75
Als	activates	disease	0.75
Apoptosis	activates	pathway	0.70
Hepatic Fibrosis	activates	disease	0.70
GLIAL FIBRILLARY ACIDIC PROTEIN	inhibits	biomarker	0.65
GLIAL FIBRILLARY ACIDIC PROTEIN	activates	biomarker	0.65
GLIAL FIBRILLARY ACIDIC PROTEIN	regulates	biomarker	0.65
Colorectal Cancer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Senescence	activates	disease	0.65
Cancer	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Obesity	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Inflammation	activates	disease	0.65
GFAP	inhibits	gene	0.65
GFAP	regulates	gene	0.65
Carcinoma	treats	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	treats	disease	0.65
Pancreatic Cancer	treats	disease	0.65
Neuroinflammation	activates	disease	0.65
HYPOTHALAMUS	regulates	brain_region	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Pancreatic Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Lung Cancer	inhibits	disease	0.65
RAS	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
P16	expressed_in	gene	0.60
BCL-2	expressed_in	gene	0.60
P21	expressed_in	gene	0.60
Cell Cycle	expressed_in	pathway	0.60
Cytokine	activates	protein	0.60
ACSL4	activates	gene	0.60
SMAD3	regulates	gene	0.60
APC	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
AMYLOID	inhibits	gene	0.60
OVERVIEW	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
Immune Response	inhibits	pathway	0.60

Incoming (79)

Source	Relation	Type	Str
CRL4-AMBRA1	modifies	protein	0.90
AMBRA1	modifies	protein	0.90
BMPR1A	associated_with	gene	0.80
NEURODEGENERATION	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
P53	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MITOCHONDRIA	activates	gene	0.60
AMYLOID	activates	gene	0.60
AND	regulates	gene	0.60
DCX	activates	gene	0.60
IL6	activates	gene	0.60
TNF	activates	gene	0.60
IL1B	activates	gene	0.60
GAL	activates	gene	0.60
TUBULIN	activates	gene	0.60
SMAD1	activates	gene	0.60
GFAP	activates	gene	0.60
APP	activates	gene	0.60
SMAD2	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
KRAS	inhibits	gene	0.60
TGFB	regulates	gene	0.60
NIX	activates	gene	0.60
KRAS	associated_with	gene	0.60
CYCLIN D1	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
MITOPHAGY	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
ABCC8	associated_with	gene	0.60
AQP1	associated_with	gene	0.60
BMPR1B	associated_with	gene	0.60
NOTCH3	associated_with	gene	0.60
SMAD1	associated_with	gene	0.60
BMPR1A	expressed_in	gene	0.60
PPP1CB	expressed_in	gene	0.60
MAP1LC3	activates	gene	0.60
SMAD3	inhibits	gene	0.60
MIRNAS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
P21	activates	gene	0.60
CYTOKINES	activates	gene	0.60
AND	activates	gene	0.60
BNIP3	activates	gene	0.60
TGFB1	activates	gene	0.60
FUNDC1	activates	gene	0.60
SMAD3	regulates	gene	0.60
BNIP3L	activates	gene	0.60
SMAD2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMAD4 in their description or question text

No additional research found