concept

PARKINSON DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARKINSON DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

289Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	PARKINSON DISEASE
Key Genes/Proteins	ACHE, AD, AIF1, AKT, ALS, AMPK
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
Related Pathways	APOPTOSIS

Pathway Diagram

graph TD
    PARKINSON_DISEASE["PARKINSON DISEASE"]
    PARKINSON_DISEASE -->|"risk_factor_for"| Dementia["Dementia"]
    PARKINSON_DISEASE -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
    Rotenone["Rotenone"] -->|"causes"| PARKINSON_DISEASE
    PRKN["PRKN"] -->|"risk_factor_for"| PARKINSON_DISEASE
    Mitochondrial_Dysfunction["Mitochondrial Dysfunction"] -->|"contributes to"| PARKINSON_DISEASE
    Vinpocetine["Vinpocetine"] -.protects against.-> PARKINSON_DISEASE
    Ageing["Ageing"] -->|"risk_factor_for"| PARKINSON_DISEASE
    Snca["Snca"] -.biomarker for.-> PARKINSON_DISEASE
    GBA["GBA"] -->|"risk_factor_for"| PARKINSON_DISEASE

Outgoing (72)

Target	Relation	Type	Str
Dementia	causes	disease	0.95
Dementia	risk_factor_for	disease	0.95
Dementia Risk	risk_factor_for	phenotype	0.95
Cognitive Impairment	causes	phenotype	0.92
Cognitive Decline	associated_with	phenotype	0.90
PSEN1	inhibits	gene	0.60
VPS35	inhibits	gene	0.60
RIPK3	activates	gene	0.60
SNCA	associated_with	gene	0.60
RAGE	interacts_with	gene	0.60
VCP	activates	gene	0.60
PD	activates	gene	0.60
PINK1	activates	gene	0.60
SQSTM1	activates	gene	0.60
SRC	activates	gene	0.60
STAT3	activates	gene	0.60
STING	activates	gene	0.60
TNF	activates	gene	0.60
TRAF6	activates	gene	0.60
ULK1	activates	gene	0.60
PD	markers	gene	0.60
PROGRESSIVE SUPRANUCLEAR PALSY	co_discussed	disease	0.60
SOD1	co_discussed	gene	0.60
SOD1	regulates	gene	0.60
SOD1	associated_with	gene	0.60
PD	disrupts	gene	0.60
PD	inhibits	gene	0.60
TFEB	inhibits	gene	0.60
VPS35	associated_with	gene	0.60
VPS35	regulates	gene	0.60
PD	causes	gene	0.60
SNCA	targets	gene	0.60
TAU	activates	gene	0.60
PARKINSON'S DISEASE	causes	disease	0.60
PINK1	causes	gene	0.60
PINK1	regulates	gene	0.60
PINK1	co_discussed	gene	0.60
RAGE	co_discussed	gene	0.60
PD	mediates	gene	0.60
RAGE	associated_with	gene	0.60
TAU	associated_with	gene	0.60
TAU	enhances	gene	0.60
TFEB	co_discussed	gene	0.60
SQSTM1	inhibits	gene	0.60
TAU	targets	gene	0.60
PD	regulates	gene	0.60
SOD1	activates	gene	0.60
TARDBP	activates	gene	0.60
PD	associated_with	gene	0.60
PD	co_discussed	gene	0.60

Incoming (217)

Source	Relation	Type	Str
entities-atp7b-gene	associated_with	wiki	0.00
Rotenone	causes	compound	0.95
Vinpocetine	protects_against	drug	0.95
LRRK2	causes	gene	0.95
Neuroinflammation	contributes_to	process	0.95
Snca	biomarker_for	biomarker	0.95
PINK1	associated_with	gene	0.95
Mitochondrial Dysfunction	contributes_to	process	0.95
Neural Mitochondrial Dysfunction	contributes_to	process	0.95
PRKN	risk_factor_for	gene	0.95
GBA	risk_factor_for	gene	0.95
Levodopa	treats	drug	0.95
Ageing	risk_factor_for	process	0.95
Reactive Oxygen Species	contributes_to	process	0.95
LRRK2	risk_factor_for	gene	0.95
GBA1	risk_factor_for	gene	0.95
SNCA	associated_with	gene	0.95
NLRP3	involved_in	protein	0.90
LNK	associated_with	gene	0.90
PINK1	risk_factor_for	gene	0.90
Vinpocetine	treats	drug	0.90
Autophagy	involved_in	process	0.90
Oxidative Stress	contributes_to	process	0.90
GBA	contributes_to	gene	0.90
Astrocytes	contributes_to	cell_type	0.90
Hph-Rnpec	treats	drug	0.90
COMT	associated_with	gene	0.90
Lysosomal Dysfunction	contributes_to	mechanism	0.90
NLRP3	risk_factor_for	gene	0.90
Kaempferol	protects_against	compound	0.90
LRRK2	associated_with	gene	0.90
23266198	increase the risk for developing	paper	0.90
23266198	increase risk for	paper	0.90
PBT434	treats	compound	0.90
Ps1292-Lrrk2	biomarker_for	biomarker	0.88
G2019S-Lrrk2 Mutation	risk_factor_for	phenotype	0.88
HDAC6	associated_with	protein	0.85
Inflammasome	associated_with	pathway	0.85
SNCA	biomarker_for	gene	0.85
Icariin	treats	compound	0.85
MIRO1	associated_with	gene	0.85
PI3K/AKT/mTOR	associated_with	pathway	0.80
NLRP3 inflammasome	implicated_in	complex	0.80
IL6	biomarker_for	protein	0.80
LYSOSOMAL PROTEINS	causes	protein	0.80
NLRP3	implicated_in	gene	0.80
Myelin Repair	protects_against	process	0.80
AMBRA1	associated_with	protein	0.80
mitophagy impairment	associated_with	process	0.75
Venglustat	treats	drug	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

completed · Rounds: 5 · Score: 0.50 · 2026-04-25

Related Research

Hypotheses and analyses mentioning PARKINSON DISEASE in their description or question text

No additional research found