concept

SESTRIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SESTRIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SESTRIN2
Key Genes/Proteins	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
Related Diseases	Als, Alzheimer
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    SESTRIN2["SESTRIN2"]
    style SESTRIN2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SESTRIN2 -->|"interacts"| ULK1([ULK1])
    SESTRIN2 -->|"interacts"| P62([P62])
    SESTRIN2 -.->|"inhibits"| mTORC1([mTORC1])
    SESTRIN2 -->|"regulates"| Autophagy["Autophagy"]
    SESTRIN2 -->|"interacts"| SQSTM1([SQSTM1])
    SESTRIN2 -->|"interacts"| Alzheimer["Alzheimer"]
    SESTRIN2 -->|"interacts"| Cardiovascular["Cardiovascular"]
    SESTRIN2 -->|"interacts"| Parkinson["Parkinson"]
    XBP1([XBP1]) -->|"upregulates"| SESTRIN2
    ULK1 -->|"phosphorylates"| SESTRIN2
    LC3([LC3]) -->|"interacts"| SESTRIN2
    CALCOCO2([CALCOCO2]) -->|"interacts"| SESTRIN2
    CATALASE([CATALASE]) -->|"interacts"| SESTRIN2
    PRESENILIN([PRESENILIN]) -->|"interacts"| SESTRIN2
    BNIP3L([BNIP3L]) -->|"interacts"| SESTRIN2
    MITOCHONDRIA([MITOCHONDRIA]) -->|"interacts"| SESTRIN2
    NLR([NLR]) -->|"interacts"| SESTRIN2
    MFN1([MFN1]) -->|"interacts"| SESTRIN2

Outgoing (100)

Target	Relation	Type	Str
P62	interacts_with	protein	0.95
ULK1	interacts_with	protein	0.95
mTORC1	inhibits	protein	0.95
Autophagy	regulates	process	0.93
ULK1	modulates	protein	0.92
SQSTM1	interacts_with	protein	0.90
Protein Aggregate Degradation	associated_with	process	0.88
Autophagy	activates	process	0.85
p62/sequestosome-1	promotes	protein	0.80
Unc-51-like kinase 1	promotes	protein	0.80
Als	interacts_with	disease	0.65
Obesity	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
ALS	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60

Incoming (77)

Source	Relation	Type	Str
XBP1	upregulates	protein	0.92
ULK1	phosphorylates	protein	0.85
NRF2	activates	gene	0.60
PTEN	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
PHB2	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
MITOCHONDRIA	activates	gene	0.60
AND	activates	gene	0.60
LC3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CATALASE	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SESTRIN2 in their description or question text

No additional research found