concept

MTORC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTORC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1943Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MTORC1 is a concept in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with AD, ADH, ALS. Connected to 1023 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MTORC1
Key Genes/Proteins	4EBP1, 4EBP1/2, 4EBP2, ABCA1, ABL1, ACC1
Related Diseases	AD, ADH
Related Pathways	Adaptive Immunity

Pathway Diagram

graph TD
    MTORC1["MTORC1"]
    MTORC1 -->|"inhibits"| ULK1["ULK1"]
    MTORC1 -->|"contributes to"| protein_synthesis["protein synthesis"]
    MTORC1 -->|"inhibits"| autophagy["autophagy"]
    MTORC1 -->|"inhibits"| TFEB["TFEB"]
    MTORC1 -->|"inhibits"| AUTOPHAGY["AUTOPHAGY"]
    MTORC1 -->|"activates"| lipogenesis["lipogenesis"]
    PRKAA["PRKAA"] -->|"inhibits"| MTORC1
    endocytosis["endocytosis"] -->|"activates"| MTORC1
    alpha_synuclein["alpha-synuclein"] -->|"activates"| MTORC1
    AKT["AKT"] -->|"activates"| MTORC1
    RAPAMYCIN["RAPAMYCIN"] -->|"inhibits"| MTORC1
    raptor["raptor"] -->|"activates"| MTORC1
    TSC2["TSC2"] -->|"inhibits"| MTORC1
    STING1["STING1"] -->|"activates"| MTORC1

Outgoing (1122)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
Mtor	associated_with	pathway	1.00
MTOR	inhibits	gene	1.00
Tumor	inhibits	disease	1.00
AUTOPHAGY	activates	gene	1.00
Mtor	interacts_with	pathway	1.00
Mtor	inhibits	pathway	1.00
Tumor	activates	disease	1.00
Mtor	activates	pathway	1.00
autophagy	inhibits	pathway	1.00
Cancer	interacts_with	disease	1.00
Autophagy	activates	pathway	1.00
AKT	activates	gene	1.00
Mtor	regulates	pathway	1.00
AUTOPHAGY	inhibits	pathway	1.00
Cancer	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
CANCER	activates	gene	1.00
MTOR	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
Als	interacts_with	disease	1.00
MTOR	interacts_with	gene	1.00
AKT	regulates	gene	1.00
Autophagy	regulates	pathway	1.00
CANCER	interacts_with	gene	1.00
Als	regulates	disease	0.95
Fibrosis	therapeutic_target	disease	0.95
Cancer	inhibits	disease	0.95
Chondrocytes	expressed_in	cell_type	0.95
Apoptosis	associated_with	process	0.95
Cellular Growth	regulates	process	0.95
Cancer	regulates	disease	0.95
SREBP1	upregulates	protein	0.95
Amino Acid Sensing	involved_in	process	0.95
mRNA Translation	activates	process	0.95
Aging	therapeutic_target	disease	0.95
Mtdna Replication	regulates	process	0.95
TFEB	upstream_of	protein	0.95
Inflammation	therapeutic_target	disease	0.95
Cell Growth	regulates	process	0.95
mTOR Signaling	activates	pathway	0.95
protein synthesis	contributes_to	phenotype	0.90
ULK1	inhibits	protein	0.90
ULK1	regulates	protein	0.90
Anabolic Processes	regulates	process	0.90
4EBP1	regulates	protein	0.90
neural stem cells	regulates	cell_type	0.90

Incoming (821)

Source	Relation	Type	Str
AMPK	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Rapamycin	inhibits	drug	0.95
SLC38A9	activates	protein	0.95
RAG	activates	protein	0.95
SESTRIN2	inhibits	protein	0.95
Rapamycin	targets	drug	0.95
MTOR	component_of	gene	0.95
Lysosomal Cholesterol	activates	compound	0.95
Amino Acids	activates	compound	0.95
SLC38A9	mediates	protein	0.95
KLHL22	activates	protein	0.95
alpha-synuclein	activates	protein	0.90
RRAGA	activates	gene	0.90
Endocytosis	activates	process	0.90
rapamycin	targets	drug	0.90
RPTOR	regulates	gene	0.90
PRKAA	inhibits	protein	0.90
growth factors	regulates	phenotype	0.90
nutrient levels	regulates	phenotype	0.90
ARF1	activates	protein	0.90
TSC2	inhibits	gene	0.90
RPTOR	component_of	gene	0.90
endocytosis	activates	pathway	0.90
AKT	activates	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
AUTOPHAGY	regulates	gene	0.90
PI3K	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
PI3K/Akt Pathway	regulates	pathway	0.88
Pterostilbene	inhibits	compound	0.88
RAPAMYCIN	inhibits	drug	0.87
PI3K/AKT	regulates	pathway	0.85
ERN1	activates	gene	0.85
raptor	activates	protein	0.85
RRAGD	interacts_with	protein	0.85
SLC38A9	interacts_with	protein	0.85
LL37	activates	protein	0.85
STING1	activates	protein	0.82
GABARAP	inhibits	protein	0.82
LC3	regulates	gene	0.80
PRKAA2	inhibits	gene	0.80
Arginine	activates	compound	0.80
FLCN-FNIP Complex	inhibits	protein	0.80
TSC2	inhibits	protein	0.80
MAP1LC3	regulates	gene	0.80
INFLAMMATION	therapeutic_target	gene	0.80
TFEB	activates	gene	0.80
SQSTM1	activates	gene	0.80
APOPTOSIS	activates	gene	0.80

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
mTORC1 Reactivation as Autophagy-Senescence Divergence Point	0.685	molecular biology	What is the optimal therapeutic window t
mTORC1 displacement from lysosomal surface enables calcineur	0.650	neurodegeneration	What determines the specificity of calci
mTORC1 Hyperactivation Impairs Autophagic Flux and Drives Se	0.600	neurodegeneration	What molecular mechanisms drive microgli
Chronic mTORC1-ULK1 signaling blocks autophagy initiation in	0.578	neurodegeneration	What specific autophagy pathways are def

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MTORC1 in their description or question text

No additional research found