gene

KEAP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KEAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1193Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for KEAP1 — Kelch-Like ECH-Associated Protein 1

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🧬 Gene Info

Gene Symbol	KEAP1
Full Name	Kelch-like ECH-Associated Protein 1
Aliases	Page for KEAP1
Protein Type	Adaptor Protein
Function	High-Affinity Binding: ETGE motif of NRF2 binds to one Kelch domain (hinge)
Molecular Weight	70 kDa
Amino Acids	624 aa
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Differentiation
UniProt ID	Q14145
GeneCards	KEAP1
Human Protein Atlas	KEAP1
Associated Diseases	Aging, Als, Alzheimer, AUTOPHAGY, Cancer
Known Drugs/Compounds	DOXORUBICIN, Epalrestat, EPALRESTAT, EPS, Fumarate, gastrodin
Interactions	ACHE, ACOD1, Actin, AD, AGING, AIFM1
KG Connections	1188 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KEAP1 — AlphaFold Q14145 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KEAP1["KEAP1"] -->|"Ubiquitinates"| NRF2["NRF2"]
    KEAP1 -->|"Degrades"| NRF2
    KEAP1 -->|"Interacts with"| CUL3["CUL3 E3 Ligase"]
    CUL3 -->|"Forms complex"| KEAP1
    Electrophiles["Electrophilic Agents"] -->|"Inhibit"| KEAP1
    Methylglyoxal["Methylglyoxal"] -->|"Modifies"| KEAP1
    Gastrodin["Gastrodin"] -.Interacts with.-> KEAP1
    SQSTM1["SQSTM1/p62"] -->|"Competes for"| KEAP1
    SQSTM1G427R["SQSTM1 G427R"] -.Impairs.-> KEAP1
    NRF2 -->|"Activates"| ARE["Antioxidant Response Elements"]
    ARE -->|"Induces"| Detox["Detoxification Genes"]
    ARE -->|"Induces"| AntiOx["Antioxidant Genes"]
    KEAP1 -.Implicated in.-> Obesity["Obesity"]

Outgoing (767)

Target	Relation	Type	Str
KEAP1	encodes	protein	0.00
Tumor	activates	disease	1.00
NRF2	inhibits	protein	1.00
Cancer	activates	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
Als	activates	disease	1.00
Oxidative Stress	regulates	pathway	1.00
GENES	activates	gene	1.00
SQSTM1	activates	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
Oxidative Stress	activates	pathway	1.00
GENES	regulates	gene	1.00
NRF2	activates	gene	1.00
P62	activates	gene	1.00
Ferroptosis	activates	pathway	1.00
Tumor	inhibits	disease	1.00
UBIQUITIN	interacts_with	gene	1.00
FERROPTOSIS	activates	gene	1.00
NRF2	regulates	protein	1.00
P62	interacts_with	gene	1.00
Oxidative Stress	inhibits	pathway	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
NRF2	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
Ferroptosis	inhibits	pathway	1.00
CANCER	activates	gene	1.00
CUL3	interacts_with	gene	0.99
Als	regulates	disease	0.95
Carcinoma	activates	disease	0.95
Inflammation	regulates	disease	0.95
Hepatocellular Carcinoma	activates	disease	0.95
NFE2L2	interacts_with	protein	0.95
Nrf2	inhibits	entity	0.90
Nrf2-mediated Antioxidant Response	involved_in	pathway	0.90
UBIQUITIN	regulates	gene	0.90
UBIQUITIN	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
Oxidative Stress	associated_with	pathway	0.90
NRF2	interacts_with	protein	0.90
OXIDATIVE STRESS	associated_with	gene	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
AKT	activates	gene	0.90
NFE2L2	activates	gene	0.90
Apoptosis	activates	pathway	0.90
AMPK	activates	gene	0.90
FERROPTOSIS	inhibits	gene	0.90
Inflammation	inhibits	disease	0.85
Aging	regulates	disease	0.85
Nfe2L2	component_of	pathway	0.85
Inflammation	activates	disease	0.85

Incoming (426)

Source	Relation	Type	Str
KEAP1	encodes	gene	0.00
ROS	activates	gene	1.00
SESN2	regulates	gene	0.95
Epalrestat	binds	drug	0.95
Ric	downregulates	process	0.90
SQSTM1	associated_with	protein	0.90
Succinic Anhydride	binds	compound	0.90
Autophagy	degrades	process	0.90
NRF2	binds	gene	0.90
SQSTM1	mediates	protein	0.90
SQSTM1G427R	inhibits	protein	0.90
SQSTM1	interacts_with	protein	0.90
MCL	binds_to	drug	0.90
gastrodin	interacts_with	drug	0.90
methylglyoxal	modifies	protein	0.90
AUTOPHAGY	activates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
P62	associated_with	protein	0.88
Macroautophagy	degrades	process	0.88
EPALRESTAT	targets	drug	0.85
electrophilic agents	inhibits	phenotype	0.85
Itaconate	binds	compound	0.85
Methylglyoxal	binds	compound	0.85
Fumarate	binds	compound	0.85
NRF2	inhibits	protein	0.82
SQSTM1	binds	gene	0.80
P62	targets	gene	0.80
itaconate	inhibits	metabolite	0.80
IFNΓ	upregulates	protein	0.80
GPX4	inhibits	gene	0.80
ROS	regulates	gene	0.80
APOPTOSIS	activates	gene	0.80
Tocopherol	modulates	compound	0.75
AUTOPHAGY	inhibits	pathway	0.74
EPS	interacts_with	drug	0.72
NRF2	interacts_with	protein	0.72
JAK	activates	gene	0.70
CYP46A1	activates	gene	0.70
CYP46A1	expresses	gene	0.70
HO1	associated_with	gene	0.70
AMPK	regulates	gene	0.70
BECN1	regulates	gene	0.70
AMPK	associated_with	gene	0.70
GPX4	associated_with	gene	0.70
BACE1	activates	gene	0.70
APOPTOSIS	regulates	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
AGING	regulates	gene	0.70
P62	inhibits	gene	0.70
P62	activates	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NRF2-KEAP1 Pathway Activation to Coordinate Multi-Layer Anti	0.650	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KEAP1 in their description or question text

No additional research found