disease

SCHIZOPHRENIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCHIZOPHRENIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1373Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Reward Processing	Incentive motivation
Prediction Error	Learning signals
Salience	Psychosis symptoms
Associated Genes	AKT, AMYLOID, APOE, BDNF, CACNA1G, CASP3, CLOCK, CYTOKINES
KG Connections	483 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VTA Dopamine Neurons in Schizophrenia

cell · 575 words

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Pathway Diagram

graph TD
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"associated"| SYNGR1["SYNGR1"]
    style SYNGR1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| SLEEP["SLEEP"]
    style SLEEP fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| SYNAPSE["SYNAPSE"]
    style SYNAPSE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| TEMPORAL_LOBE["TEMPORAL LOBE"]
    style TEMPORAL_LOBE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    RELN["RELN"] -->|"implicated in"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style RELN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S["ALZHEIMER'S"] -->|"causes"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style ALZHEIMER_S fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    PARKIN["PARKIN"] -->|"causes"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style PARKIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style SCHIZOPHRENIA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (357)

Target	Relation	Type	Str
interneurons	affects	cell_type	0.90
neurons	affects	cell_type	0.90
cortex	affects	brain_region	0.90
Als	associated_with	disease	0.85
serotonin	disrupts	neurotransmitter	0.80
NMDA receptor	involves	receptor	0.80
oxidative stress response	involves	pathway	0.80
Synaptic Plasticity	implicated_in	pathway	0.80
Depression	associated_with	disease	0.75
synaptic plasticity	involves	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
blood-brain barrier	affects	brain_region	0.70
pyramidal neurons	affects	cell_type	0.70
thalamus	affects	brain_region	0.70
striatum	affects	brain_region	0.70
nicotinic receptor	involves	receptor	0.70
dopamine receptor	involves	receptor	0.70
cerebellum	affects	brain_region	0.70
Anxiety	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
CEREBELLUM	interacts_with	brain_region	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
TH	inhibits	gene	0.65
DOPAMINE	regulates	phenotype	0.65
STING	regulates	gene	0.65
Apoptosis	therapeutic_target	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
microglia	affects	cell_type	0.60
TH	impairs	gene	0.60
STING	contributes_to	gene	0.60
Oxidative Stress	biomarker_for	pathway	0.60
STROKE	associated_with	disease	0.60
epigenetic regulation	involves	pathway	0.60
endothelial cells	affects	cell_type	0.60
macrophages	affects	cell_type	0.60
ubiquitin-proteasome	involves	pathway	0.60
GABAergic neurons	affects	cell_type	0.60
Neurogenesis	contributes_to	pathway	0.60
neural stem cells	affects	cell_type	0.60
oxytocin	disrupts	neurotransmitter	0.60
prefrontal cortex	affects	brain_region	0.60
temporal lobe	affects	brain_region	0.60
nucleus accumbens	affects	brain_region	0.60
subventricular zone	affects	brain_region	0.60
muscarinic receptor	involves	receptor	0.60
cerebral cortex	affects	brain_region	0.60
neuropeptide Y	disrupts	neurotransmitter	0.60
ferroptosis	involves	pathway	0.60

Incoming (1016)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
PLA2G4A	risk_factor_for	gene	0.95
TNFSF	upregulates	pathway	0.95
TNFSF	implicated_in	pathway	0.95
dopamine signaling	implicated_in	pathway	0.95
Metabolism And Inflammation-Related Genes	involved_in	pathway	0.95
C4A	risk_factor_for	gene	0.93
C4B	risk_gene_for	gene	0.90
RLN1	associated_with	protein	0.90
Dopamine	associated_with	entity	0.90
Postsynaptic Interactomes	associated_with	pathway	0.90
Dopamine Signaling	associated_with	pathway	0.90
FUCA1	biomarker_for	gene	0.85
SNAP25	biomarker_for	gene	0.85
CD40LG	biomarker_for	gene	0.85
HDC	biomarker_for	gene	0.85
NCKAP1L	biomarker_for	gene	0.85
CX3CR1	biomarker_for	gene	0.85
RELN	implicated_in	entity	0.85
Mtnr1B	therapeutic_target	protein	0.85
Cpla2	involved_in	protein	0.85
Complement Activation	contributes_to	process	0.85
RLN	associated_with	protein	0.85
DEPRESSION	associated_with	gene	0.85
Pla2 Superfamily	involved_in	protein	0.85
mTOR-Dependent Autophagy Dysfunction	contributes_to	mechanism	0.85
OXIDATIVE STRESS	therapeutic_target	gene	0.85
Lipid Homeostasis	involved_in	process	0.85
Tnf Receptor Inhibition	therapeutic_target	mechanism	0.85
Haloperidol	risk_factor_for	drug	0.85
LCPUFA Deficiency	risk_factor_for	phenotype	0.85
Serotonin	associated_with	compound	0.80
Reelin Signaling Pathway	associated_with	pathway	0.80
MICROBIOTA	implicated_in	biological_process	0.80
MTOR Inhibitors	treats	drug	0.80
REELIN	implicated_in	protein	0.80
CHRFAM7A	implicated_in	gene	0.80
Lcpufa Deficiency	causes	phenotype	0.80
cytosolic phospholipase A2	biomarker_for	protein	0.80
PLA2G12F	risk_factor_for	gene	0.80
NPAS3	associated_with	gene	0.80
Microbiota	associated_with	process	0.80
PLA2G4F	risk_factor_for	gene	0.80
BIPOLAR DISORDER	associated_with	disease	0.80
PLA2G4A	affects	gene	0.80
Lipid Homeostasis	contributes_to	process	0.80
ALZHEIMER'S DISEASE	interacts_with	disease	0.80
Cpla2	biomarker_for	biomarker	0.80
PLA2 Superfamily	involved_in	pathway	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity