gene 2,253 words KG: FMR1
Contents

FMR1 — Fragile X Messenger Ribonucleoprotein 1

🧬 Gene Info
Gene SymbolFMR1
Full NameFragile X Messenger Ribonucleoprotein 1
ChromosomeXq27.3
Primary Expressionbrain tissue, particularly in neurons of the cerebral cortex, hippocampus, cerebellum, and amygdala
Subcellular Localizationdendritic spines and shafts, where it associates with translating ribosomes and neuronal mRNA granules. This localizatio
Molecular Weight71 kDa
Amino Acids632 aa
PathwaysEr Stress
UniProt ID[Q06787](https://www.uniprot.org/uniprot/Q06787)
Ensembl IDENSG00000102081
GeneCardsFMR1
Human Protein AtlasFMR1
Associated DiseasesAD, ALI, Als, Alzheimer, Ataxia
Known Drugs/Compoundsrapamycin
InteractionsABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections584 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio
validation · proposed · Score: 0.40

See Also (13)

Astrocytes
cell · KG edge: expressed_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: co_discussed
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: expressed_in
ABCD3 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with FMR1
OPTN interacts_with FMR1
DNM1L interacts_with FMR1
CANX interacts_with FMR1
LGALS3 interacts_with FMR1
CALCOCO2 interacts_with FMR1
G3BP1 interacts_with FMR1
PEX3 interacts_with FMR1
SQSTM1 interacts_with FMR1
BCL2 interacts_with FMR1

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