protein

TDP43

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

249Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

TDP43 is a protein involved in neurodegeneration research. Key relationships include: associated with, causes, biomarker for. Associated with ALS, Als, Alzheimer. Connected to 73 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TARDBP
Aliases	TAR DNA-binding protein 43
Chromosome	1p36.2
Protein Family	Heterogeneous nuclear ribonucleoprotein (hnRNP) family
Function	is a highly conserved RNA/DNA-binding protein encoded by the TARDBP gene on chromosome 1p36.
Primary Expression	Nucleus (physiological), cytoplasm (disease)
Molecular Weight	43 kDa (414 amino acids)
Amino Acids	414 aa
Exons	2
Pathways	RNA metabolism, Stress granules, Protein aggregation
UniProt ID	Q13148
GeneCards	TARDBP
Human Protein Atlas	TARDBP
Protein dimerization	The NTD mediates homodimer formation, essential for functional activity[@chang2019]
Nuclear localization	Contains a basic nuclear localization signal (NLS, residues 82-98)
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia
Interactions	Actin, AKT, ALS, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections	248 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TDP43 — AlphaFold Q13148 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Update TDP-43 protein page with comprehensive content

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Pathway Diagram

graph TD
    TDP43["TDP-43 Protein"] -->|"Normally in"| Nucleus["Nucleus"]
    TDP43 -->|"Regulates"| RNA["RNA Splicing and Stability"]
    Stress["Cellular Stress"] -->|"Causes"| Mislocalization["Cytoplasmic Mislocalization"]
    Mislocalization -->|"Forms"| Aggregates["Cytoplasmic Aggregates"]
    Aggregates -->|"Loss of"| Function["Nuclear Function"]
    Aggregates -->|"Gain of"| Toxicity["Cytoplasmic Toxicity"]
    TDP43 -.Pathology found in.-> ALS["ALS"]
    TDP43 -.Pathology found in.-> FTD["Frontotemporal Dementia"]
    TDP43 -.Also occurs in.-> AD["Alzheimer's Disease"]

Outgoing (163)

Target	Relation	Type	Str
ALS	associated_with	disease	0.97
ALS	biomarker_for	entity	0.95
Frontotemporal Dementia	associated_with	disease	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
UNC13A	regulates	gene	0.95
Lc3Ylation	regulates	process	0.95
Biomolecular Condensates	involved_in	process	0.95
ALZHEIMER'S DISEASE	associated_with	entity	0.95
Frontotemporal Lobar Degeneration	associated_with	disease	0.95
STATHMIN2	regulates	gene	0.95
Nanocondensates	associated_with	mechanism	0.95
Liquid-Liquid Phase Separation	associated_with	process	0.95
Mis-Splicing	causes	mechanism	0.95
Stress Granules	involved_in	cell_type	0.93
Mis-splicing	mediates	process	0.92
Fibril Formation	involved_in	process	0.92
LC3	regulates	entity	0.92
Amyloid	interacts_with	process	0.90
MITOCHONDRIAL DNA	causes	entity	0.90
Cryptic Splicing	inhibits	process	0.90
Blood-Brain Barrier Breakdown	contributes_to	phenotype	0.90
NEURODEGENERATION	contributes_to	entity	0.90
STMN2	binds	protein	0.90
Blood-Brain Barrier	associated_with	process	0.90
STING	activates	entity	0.90
COGNITIVE IMPAIRMENT	contributes_to	entity	0.90
Endothelial Cells	expressed_in	cell_type	0.90
UNC13A	causes	protein	0.90
Motor Neuron Degeneration	causes	phenotype	0.90
STATHMIN2	binds	gene	0.90
ATG4B	inhibits	entity	0.90
Mitochondrial DNA Release	associated_with	process	0.90
translation fidelity	regulates	process	0.90
Phase Transition	associated_with	process	0.88
Neuronal Vulnerability	mediates	phenotype	0.85
Pre-mRNA	regulates	compound	0.85
HIPPOCAMPUS	expressed_in	entity	0.85
Neurodegeneration	associated_with	disease	0.85
Neurodegeneration	biomarker_for	disease	0.85
Long Terminal Repeat	binds	biomarker	0.85
TAU	co_expressed_with	entity	0.85
HERV-K	regulates	gene	0.85
RNA Transcripts	regulates	biomarker	0.85
CTNNB1	regulates	protein	0.85
cGAS/STING Pathway	activates	pathway	0.85
RNA	binds	entity	0.80
Translation Fidelity	associated_with	process	0.80
frontotemporal dementia	interacts_with	disease	0.80
PABPN1	interacts_with	protein	0.80
TNF/NF-κB Signaling	regulates	pathway	0.80

Incoming (86)

Source	Relation	Type	Str
TARDBP	expresses	gene	1.00
FMR1	interacts_with	gene	0.95
TARDBP	regulates	gene	0.90
APOE	regulates	entity	0.90
FTLD	interacts_with	gene	0.70
ATXN2	interacts_with	protein	0.70
ATXN2 polyQ expansions	inhibits	protein	0.70
FUS	co_discussed	gene	0.65
OXIDATIVE_STRESS	regulates	phenotype	0.64
PINK	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ALS	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
AND	activates	gene	0.60
ALS	interacts_with	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
DEMENTIA	co_discussed	gene	0.60
ALS	co_discussed	gene	0.60
NEURODEGENERATION	co_discussed	gene	0.60
FTLD	associated_with	gene	0.60
TAR	interacts_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DEMENTIA	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
FUS	associated_with	gene	0.60
FUS	regulates	gene	0.60
HSPB8	interacts_with	gene	0.60
HSPB8	regulates	gene	0.60
CHCHD10	interacts_with	gene	0.60
CHCHD2	interacts_with	gene	0.60
FUS	biomarker_for	gene	0.60
MLH1	expressed_in	gene	0.60
TARDBP	causes	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
TAR	regulates	gene	0.60
DNA	regulates	gene	0.60
DNA	activates	gene	0.60
MSH6	expressed_in	gene	0.60
UNC13A	expressed_in	gene	0.60
TDP-43	associated_with	gene	0.60
GFAP	activates	gene	0.60
FUS	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
GFAP	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Protein aggregation cross-seeding across neurodegenerative diseases?

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.53 · 2026-04-06

Related Research

Hypotheses and analyses mentioning TDP43 in their description or question text

No additional research found