concept

ATAXIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATAXIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

827Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATAXIA is a concept in neurodegeneration research. Key relationships include: activates, co discussed, transports. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 50 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ATAXIA
Key Genes/Proteins	ACHE, AMPK, ATG7, BCL2, BECN1, CGAS
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cerebellar Granule Cells in Ataxia

cell · 680 words

→

Pathway Diagram

graph TD
    ATAXIA["ATAXIA"]
    ATAXIA -->|"target for"| Immune_Response["Immune Response"]
    ATAXIA -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    ATAXIA -->|"target for"| Mitochondrial_Function["Mitochondrial Function"]
    CALCINEURIN["CALCINEURIN"] -->|"activates"| ATAXIA
    ATG12["ATG12"] -->|"activates"| ATAXIA
    ATG10["ATG10"] -->|"activates"| ATAXIA
    HSPA1A["HSPA1A"] -->|"regulates"| ATAXIA
    DNAJB1["DNAJB1"] -->|"regulates"| ATAXIA
    GENES["GENES"] -->|"activates"| ATAXIA
    DNA["DNA"] -->|"target for"| ATAXIA

Outgoing (250)

Target	Relation	Type	Str
Als	associated_with	disease	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
Parkinson	associated_with	disease	0.85
Neurodegeneration	implicated_in	disease	0.85
Dementia	associated_with	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Parkinson	activates	disease	0.75
Mitochondrial Function	inhibits	pathway	0.70
Oxidative Stress	activates	pathway	0.70
PURKINJE	sensitizes_to	cell_type	0.65
SQSTM1	activates	gene	0.65
Parkinson	causes	disease	0.65
CEREBELLUM	reduces	brain_region	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	implicated_in	disease	0.65
ROS	regulates	gene	0.65
FRONTOTEMPORAL DEMENTIA	exacerbates	disease	0.65
RAPAMYCIN	interacts_with	drug	0.65
FRONTOTEMPORAL DEMENTIA	transports	disease	0.65
Aging	associated_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
LEVODOPA	mediates	drug	0.65
ROS	phosphorylates	gene	0.65
Oxidative Stress	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Senescence	inhibits	pathway	0.60
Immune Response	treats	pathway	0.60
Mitochondrial Function	implicated_in	pathway	0.60
PARKINSON'S	activates	disease	0.60
PARKINSON'S DISEASE	activates	disease	0.60
STING	activates	gene	0.60
Stem Cell	associated_with	pathway	0.60
CGAS	activates	gene	0.60
PARKIN	mediates	gene	0.60
NEURON	mediates	cell_type	0.60
MOTOR NEURON	mediates	cell_type	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
PARKINSON'S DISEASE	mediates	disease	0.60
PARKINSON'S	mediates	disease	0.60
PARKINSON	mediates	disease	0.60
PARKINSON	activates	disease	0.60

Incoming (577)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
DEMENTIA	associated_with	gene	0.95
NEURODEGENERATION	implicated_in	gene	0.95
HUNTINGTON	associated_with	gene	0.95
PARKINSON	associated_with	gene	0.95
GENES	activates	gene	0.95
DNA	associated_with	gene	0.85
Stress Granule Formation	protects_against	process	0.85
ALS	associated_with	gene	0.85
PARKINSON	activates	gene	0.85
CANCER	activates	gene	0.85
NEURODEGENERATION	associated_with	gene	0.85
ATM	activates	gene	0.85
Huntington	associated_with	disease	0.85
DNA	activates	gene	0.85
Reducing Stress Granule Formation	contributes_to	process	0.85
DNA	therapeutic_target	gene	0.75
ENDOSOMES	associated_with	gene	0.75
NRF2	therapeutic_target	gene	0.75
SCA3	associated_with	gene	0.75
HUNTINGTON'S DISEASE	associated_with	gene	0.75
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.75
ALZHEIMER	associated_with	gene	0.75
NEURODEGENERATION	regulates	gene	0.75
GAIN	implicated_in	gene	0.75
ATXN1	causes	gene	0.75
PARKINSON'S DISEASE	associated_with	gene	0.75
BDNF	protects_against	gene	0.75
NEURODEGENERATIVE DISEASES	associated_with	gene	0.75
AMYLOID	implicated_in	gene	0.75
MITOPHAGY	inhibits	gene	0.75
DRP1	associated_with	gene	0.75
APP	implicated_in	gene	0.75
HUNTINGTON	activates	gene	0.75
C9ORF72	associated_with	gene	0.75
ALZHEIMER	activates	gene	0.75
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.75
P53	activates	gene	0.75
NEUROINFLAMMATION	therapeutic_target	gene	0.75
POLG	associated_with	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
STAU1	associated_with	gene	0.65
SIL1	associated_with	gene	0.65
FMR1	associated_with	gene	0.65
NEURODEGENERATION	protects_against	gene	0.65
CLPP	associated_with	gene	0.65
MAP1LC3	associated_with	gene	0.65
GENES	causes	gene	0.65
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.65
WFS1	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity