protein

EIF2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

531Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EIF2A is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 296 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	EIF2A
Full Name	Eukaryotic Translation Initiation Factor 2A
Chromosome	3q27.1
Function	Binds the 40S ribosomal subunit
Pathways	Akt, Apoptosis, Er Stress, Wnt
UniProt ID	Q9Y5Q3
NCBI Gene ID	27185
Ensembl ID	ENSG00000144895
OMIM	609994
GeneCards	EIF2A
Human Protein Atlas	EIF2A
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, ALS, ALZHEIMER
KG Connections	530 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EIF2A — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EIF2A["EIF2A"] -->|"regulates"| stress_granules["stress granules"]
    EIF2A["EIF2A"] -->|"interacts"| Cancer["Cancer"]
    EIF2A["EIF2A"] -->|"interacts"| Als["Als"]
    EIF2A["EIF2A"] -->|"interacts"| Ms["Ms"]
    EIF2A["EIF2A"] -->|"interacts"| Fibrosis["Fibrosis"]
    EIF2A["EIF2A"] -->|"interacts"| Aging["Aging"]
    OPTN["OPTN"] -->|"interacts"| EIF2A["EIF2A"]
    CASP3["CASP3"] -->|"interacts"| EIF2A["EIF2A"]
    AKT1["AKT1"] -->|"interacts"| EIF2A["EIF2A"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| EIF2A["EIF2A"]
    style EIF2A fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (348)

Target	Relation	Type	Str
protein synthesis	regulates	process	0.90
Protein Translation	regulates	process	0.85
Endoplasmic Reticulum Stress	involved_in	process	0.85
autophagy pathway	participates_in	pathway	0.80
Als	activates	disease	0.75
Endoplasmic Reticulum Stress	biomarker_for	process	0.75
stress granules	regulates	process	0.70
oxidative stress response	participates_in	pathway	0.70
Ms	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	contributes_to	disease	0.65
ALS	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Ms	activates	disease	0.65
Aging	regulates	disease	0.65
Inflammation	interacts_with	disease	0.65
Ischemia	interacts_with	disease	0.65
Ms	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Heart Failure	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
Autophagy	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Akt	regulates	pathway	0.60
Wnt	regulates	pathway	0.60
Er Stress	regulates	pathway	0.60
ASNS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MTORC1	activates	gene	0.60
Epigenetic	activates	pathway	0.60
Mtor	activates	pathway	0.60
RAN	activates	gene	0.60
NUFIP2	activates	gene	0.60
SMCR8	activates	gene	0.60
STX17	activates	gene	0.60
TARDBP	activates	gene	0.60
TBK1	activates	gene	0.60
ULK1	activates	gene	0.60
WDR41	activates	gene	0.60
neurodegeneration	activates	disease	0.60

Incoming (183)

Source	Relation	Type	Str
TMTD	phosphorylates	compound	0.90
Stress Granules	phosphorylates	process	0.85
DTG	upregulates	drug	0.85
PERK	phosphorylates	protein	0.85
rapamycin	targets	drug	0.70
APOPTOSIS	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
RAS	interacts_with	gene	0.60
RNA	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
CYP1A1	activates	gene	0.60
ATG	activates	gene	0.60
GABARAP	associated_with	gene	0.60
ATF4	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RRAGA	interacts_with	gene	0.60
G3BP1	associated_with	gene	0.60
JUN	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
RRAGB	interacts_with	gene	0.60
TIA1	associated_with	gene	0.60
ATM	activates	gene	0.60
ATF6	activates	gene	0.60
ATF4	phosphorylates	entity	0.60
PPARG	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
DDIT3	phosphorylates	entity	0.60
EIF2AK3	interacts_with	gene	0.60
HSP27	inhibits	gene	0.60
DDIT3	activates	gene	0.60
DEPTOR	activates	gene	0.60
EGF	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMPK	activates	gene	0.60
WNT	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
TDP-43	inhibits	gene	0.60
HSP70	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ATG16L1	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
HSP90	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
eIF2alpha Dephosphorylation Threshold Prevents Pro-Apoptotic	0.445	-	What is the minimum effective dose of tr

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF2A in their description or question text

No additional research found