gene

MFF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

276Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MFF is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with Aging, Als, Cancer. Connected to 165 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MFF
Full Name	Mitochondrial Fission Factor
Chromosome	5q31.2
Protein Type	Receptor
Function	MFF is the major mitochondrial outer membrane receptor for DRP1 (Dynamin 1-like protein), mediating mitochondrial fission through
Gene Type	Protein-coding
Pathways	Immune Response, Mitochondrial Function, Mitophagy, Oxidative Stress, Wnt
UniProt ID	Q9NXG2
NCBI Gene ID	27245
Ensembl ID	ENSG00000168955
OMIM	614785
GeneCards	MFF
Human Protein Atlas	MFF
Associated Diseases	Als, Parkinson, Tumor
Interactions	ABP, Akt, AKT, AMPK, AND, ATG16L1
KG Connections	276 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MFF — AlphaFold Q9NXG2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MFF Gene

gene · 790 words

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Pathway Diagram

graph TD
    MFF["MFF"]
    MFF -->|"regulates"| Aging["Aging"]
    MFF -->|"regulates"| Glioblastoma["Glioblastoma"]
    MFF -->|"activates"| Ms["Ms"]
    MFF -->|"inhibits"| Heart_Failure["Heart Failure"]
    MFF -->|"target for"| Huntington["Huntington"]
    MFF -->|"target for"| Neurodegeneration["Neurodegeneration"]
    MFF -->|"activates"| Als["Als"]
    MFF -->|"target for"| Cardiac["Cardiac"]
    PRKAA["PRKAA"] -->|"activates"| MFF
    DRP1["DRP1"] -->|"interacts"| MFF
    TOMM20["TOMM20"] -->|"regulates"| MFF
    MAX["MAX"] -->|"regulates"| MFF
    MIRO1["MIRO1"] -->|"interacts"| MFF
    MID51["MID51"] -->|"interacts"| MFF
    MID49["MID49"] -->|"interacts"| MFF
    DNM1L["DNM1L"] -->|"regulates"| MFF
    FIS1["FIS1"] -->|"regulates"| MFF
    AMPK["AMPK"] -->|"activates"| MFF

Outgoing (166)

Target	Relation	Type	Str
Mitochondrial Fragmentation	mediates	process	0.90
Als	activates	disease	0.75
PRKN	associated_with	gene	0.70
MITOCHONDRIA	activates	gene	0.70
mitochondrial function	participates_in	pathway	0.70
LC3	activates	gene	0.70
DNM1L	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Mitophagy	activates	pathway	0.70
Tumor	associated_with	disease	0.65
Glioblastoma	regulates	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Huntington	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Infection	activates	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	inhibits	disease	0.65
Aging	regulates	disease	0.65
GBM	regulates	gene	0.60
DNM1L	regulates	gene	0.60
FIS1	regulates	gene	0.60
PINK1	activates	gene	0.60
DRP1	associated_with	gene	0.60
DRP1	interacts_with	gene	0.60
PARKIN	biomarker_for	gene	0.60
Mitophagy	inhibits	pathway	0.60
Oxidative Phosphorylation	inhibits	pathway	0.60
AMPK	activates	gene	0.60
Interleukin	inhibits	protein	0.60
Cytokine	inhibits	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ROS	protects_against	gene	0.60
PARKIN	associated_with	gene	0.60
MAX	regulates	gene	0.60
TOMM20	regulates	gene	0.60
MIRO1	interacts_with	gene	0.60
MID51	interacts_with	gene	0.60
MID49	interacts_with	gene	0.60

Incoming (110)

Source	Relation	Type	Str
PRKAA	activates	gene	0.80
MITOPHAGY	activates	gene	0.70
TOMM20	regulates	gene	0.60
MAX	regulates	gene	0.60
MIRO1	interacts_with	gene	0.60
MID51	interacts_with	gene	0.60
MID49	interacts_with	gene	0.60
DNM1L	regulates	gene	0.60
FIS1	regulates	gene	0.60
MID49	associated_with	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
FIS1	biomarker_for	gene	0.60
FIS1	activates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
AMPK	phosphorylates	entity	0.60
MITOCHONDRIA	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
WNT	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
DRP1	interacts_with	gene	0.60
AND	activates	gene	0.60
MAP1LC3	activates	gene	0.60
AMPK	activates	gene	0.60
ROS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
ROS	inhibits	gene	0.60
IL-6	activates	gene	0.60
PROINFLAMMATORY CYTOKINES	associated_with	gene	0.60
AND	inhibits	gene	0.60
DRP1	protects_against	gene	0.60
DMSO	activates	gene	0.60
GFP	activates	gene	0.60
BDNF	associated_with	gene	0.60
AND	interacts_with	gene	0.60
AGING	regulates	gene	0.60
PINK1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MFF in their description or question text

No additional research found