gene

TIMM17A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM17A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

10Outgoing

33Incoming

0Experiments

0Debates

Summary

TIMM17A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Heart Failure, Ms. Connected to 44 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TIMM17A
Full Name	Translocase of Inner Mitochondrial Membrane 17A
Chromosome	1q32.1
Function	is an essential component of the TIM22 translocase complex located in the mitochondrial inner membrane.
Primary Expression	neuronal tissues
Molecular Weight	17 kDa
Amino Acids	171 aa
Exons	6
UniProt ID	O60830 (TIM17_HUMAN)
NCBI Gene ID	10628
Ensembl ID	ENSG00000139360
GeneCards	TIMM17A
Human Protein Atlas	TIMM17A
Associated Diseases	neurodegeneration
Interactions	BECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TIMM17A — AlphaFold O60830 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

timm17a

gene · 2702 words

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Pathway Diagram

graph TD
    TIMM17A["TIMM17A"]
    Heart_Failure{"Heart Failure"}
    TIMM17A -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM17A -->|"inhibits"| Ms
    EIF2A["EIF2A"]
    TIMM17A -->|"inhibits"| EIF2A
    TFAM["TFAM"]
    TIMM17A -->|"inhibits"| TFAM
    ULK1["ULK1"]
    TIMM17A -->|"inhibits"| ULK1
    TIMM10["TIMM10"]
    TIMM17A -->|"inhibits"| TIMM10
    DNM1L["DNM1L"]
    TIMM17A -->|"inhibits"| DNM1L
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    TIMM17A -->|"inhibits"| Unfolded_Protein_Response
    Mitophagy(["Mitophagy"])
    TIMM17A -->|"inhibits"| Mitophagy
    Mtor(["Mtor"])
    TIMM17A -->|"inhibits"| Mtor
    neurodegeneration["neurodegeneration"]
    TIMM17A -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM17A
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM17A
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM17A
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| TIMM17A
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM17A
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM17A
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM17A
    TIMM23["TIMM23"]
    TIMM23 -->|"inhibits"| TIMM17A
    MTOR["MTOR"]
    MTOR -->|"inhibits"| TIMM17A
    NRF1["NRF1"]
    NRF1 -->|"inhibits"| TIMM17A
    HSPD1["HSPD1"]
    HSPD1 -->|"inhibits"| TIMM17A
    MFN2["MFN2"]
    MFN2 -->|"inhibits"| TIMM17A
    style TIMM17A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
EIF2A	inhibits	gene	0.60
Mtor	inhibits	pathway	0.60
TFAM	inhibits	gene	0.60

Incoming (33)

Source	Relation	Type	Str
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIMM17A in their description or question text

No additional research found