gene

MLKL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MLKL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1242Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MLKL is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Aging, Als. Connected to 541 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MLKL
Chromosome	16q23.1
Protein Family	RHIM domain-containing pseudo-kinase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	~54 kDa
Amino Acids	480 aa
Exons	10
Pathways	Akt, Apoptosis, Autophagy, Cell Division, Ferroptosis
UniProt ID	Q8TBX5
NCBI Gene ID	83568
Ensembl ID	ENSG00000147854
GeneCards	MLKL
Human Protein Atlas	MLKL
Associated Diseases	Als, Alzheimer's disease, autism, DEMYELINATION, disease
Known Drugs/Compounds	HSYA, metformin, METFORMIN, Necrosulfonamide, rapamycin, RAPAMYCIN
Interactions	ACSL4, Actin, AD, AIF, AIM2, AKT
KG Connections	1241 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MLKL — AlphaFold Q8TBX5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MLKL Gene

gene · 1008 words

→

MLKL Protein

protein · 620 words

→

Pathway Diagram

flowchart TD
    MLKL(["MLKL"])
    Necroptosis["Necroptosis"]
    UBA52(["UBA52"])
    autophagy["autophagy"]
    RIPK3(["RIPK3"])
    Als["Als"]
    BECN1(["BECN1"])
    ULK1(["ULK1"])
    USP7(["USP7"])
    ubiquitin(["ubiquitin"])
    Alzheimer_s_disease["Alzheimer's disease"]
    neurodegeneration["neurodegeneration"]
    Apoptosis["Apoptosis"]
    APOPTOSIS(["APOPTOSIS"])

    MLKL -->|"regulates"| Necroptosis
    MLKL -->|"interacts with"| UBA52
    MLKL -->|"activates"| autophagy
    MLKL -->|"regulates"| autophagy
    RIPK3 -->|"regulates"| MLKL
    MLKL -->|"regulates"| Als
    MLKL -->|"regulates"| BECN1
    MLKL -->|"regulates"| ULK1
    MLKL -->|"regulates"| USP7
    MLKL -->|"regulates"| ubiquitin
    MLKL -->|"protects against"| Alzheimer_s_disease
    MLKL -->|"protects against"| neurodegeneration
    MLKL -->|"activates"| Apoptosis
    MLKL -->|"regulates"| Apoptosis
    APOPTOSIS -->|"regulates"| MLKL

    style MLKL fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (725)

Target	Relation	Type	Str
MLKL	encodes	protein	0.00
Necroptosis	regulates	pathway	1.00
Autophagy	involved_in	process	0.95
Necroptosis	mediates	process	0.95
necroptosis	participates_in	pathway	0.90
UBA52	interacts_with	gene	0.90
Neuronal Necroptosis	involved_in	process	0.90
necrotic cell death	mediates	process	0.90
autophagy	regulates	pathway	0.90
Fibrosis	contributes_to	disease	0.90
autophagy	activates	pathway	0.90
Necroptosis	component_of	process	0.88
Als	regulates	disease	0.85
Necroptosis	associated_with	process	0.85
USP7	interacts_with	protein	0.85
Alzheimer's disease	implicated_in	disease	0.80
Alzheimer's disease	protects_against	disease	0.80
neuroinflammation	activates	disease	0.80
ULK1	regulates	gene	0.80
neurodegeneration	protects_against	disease	0.80
ubiquitin	regulates	protein	0.80
USP7	regulates	gene	0.80
BECN1	regulates	gene	0.80
Apoptosis	regulates	pathway	0.80
Apoptosis	activates	pathway	0.80
Amyotrophic Lateral Sclerosis	regulates	disease	0.75
SOD1	activates	gene	0.70
RIPK3	causes	gene	0.70
NFKB	interacts_with	gene	0.70
RIPK1	protects_against	gene	0.70
TLR4	activates	gene	0.70
RIPK1	causes	gene	0.70
NEURONS	activates	cell_type	0.70
ULK1	activates	gene	0.70
OLIGODENDROCYTE	associated_with	cell_type	0.70
NLRP3	expressed_in	gene	0.70
RIPK3	protects_against	gene	0.70
STING	causes	gene	0.70
TNF	expressed_in	gene	0.70
NLRP3	mediates	gene	0.70
NEURONS	protects_against	cell_type	0.70
HSV-1	regulates	process	0.70
dopaminergic neurons	regulates	cell_type	0.70
Toll-Like Receptor	regulates	pathway	0.70
Ferroptosis	regulates	pathway	0.70
Parkinson's disease	associated_with	disease	0.70
RIPK1	regulates	gene	0.70
Necroptosis	inhibits	pathway	0.70
SQSTM1	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70

Incoming (517)

Source	Relation	Type	Str
MLKL	encodes	gene	0.00
RIPK3	phosphorylates	protein	0.90
RIPK3	regulates	gene	0.90
HSYA	binds	compound	0.85
EPILEPSY	associated_with	gene	0.80
BAX	activates	gene	0.80
APOPTOSIS	regulates	gene	0.80
LRP1	activates	gene	0.70
MICROGLIA	activates	cell_type	0.70
ASTROCYTE	activates	cell_type	0.70
DOPAMINERGIC	activates	cell_type	0.70
CGAS	expresses	gene	0.70
APOE	expresses	gene	0.70
GFAP	associated_with	gene	0.70
BECN1	expresses	gene	0.70
AIF1	expresses	gene	0.70
APP	expresses	gene	0.70
BECN1	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
OPTN	inhibits	protein	0.70
RIPK3	activates	protein	0.70
Necrosulfonamide	inhibits	drug	0.70
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.70
FADD	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
RIPK1	regulates	gene	0.70
GASDERMIN	mediates	gene	0.65
IFNG	activates	gene	0.65
RIPK1	treats	gene	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
AMPK	phosphorylates	gene	0.65
NECROPTOSIS	activates	phenotype	0.65
AIF	activates	gene	0.60
GFAP	regulates	gene	0.60
HSP90	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
GPX4	protects_against	gene	0.60
HSP90	protects_against	gene	0.60
ASC	regulates	gene	0.60
LDH	activates	gene	0.60
HSP90	interacts_with	gene	0.60
ATF3	activates	gene	0.60
ATG5	activates	gene	0.60
CHOP	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
IRAK1	activates	gene	0.60
ISG15	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3B	activates	gene	0.60
HMGB1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MLKL in their description or question text

No additional research found