gene

PPARG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPARG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1189Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PPARG is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ADH, ALS. Connected to 584 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PPARG
Full Name	Peroxisome Proliferator-Activated Receptor Gamma
Chromosome	3p25.2.
Protein Type	Receptor
Function	is a member of the nuclear receptor superfamily of ligand-activated transcription factors.
Primary Expression	neurons, astrocytes, and microglia, where it modulates neuroinflammation, mitochondrial function, synaptic plasticity, and cellular survival
Molecular Weight	56 kDa
Amino Acids	505 aa
Exons	9
Pathways	Akt, Apoptosis, Autophagy, Cholesterol, Glycolysis
Ensembl ID	ENSG00000132170
GeneCards	PPARG
Human Protein Atlas	PPARG
Alternative promoters	Distinct TSS for PPARG1 and PPARG2
Epigenetic control	CpG island in promoter region
Associated Diseases	AD, ADH, Als, Alzheimer, AMI
Known Drugs/Compounds	Abscisic acid, Betulinic Acid, Bezafibrate, endogenous ligands, GW9662, ibuprofen
Interactions	ACETYL-COA, Actin, AGING, AKT, AKT1, AKT1S1
KG Connections	1189 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PPARG["PPARG"] -->|"Regulates"| fat_distribution["fat distribution"]
    PPARG["PPARG"] -->|"Regulates"| PPARGC1A["PPARGC1A"]
    PPARG["PPARG"] -->|"Encodes"| PPAR__["PPAR-gamma"]
    PPARG["PPARG"] -->|"Activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    PPARG["PPARG"] -->|"Regulates"| Ischemia["Ischemia"]
    PPARG["PPARG"] -->|"Regulates"| Ms["Ms"]
    PPARG["PPARG"] -->|"Interacts With"| Cancer["Cancer"]
    PPARG["PPARG"] -->|"Interacts With"| Als["Als"]
    Abscisic_acid["Abscisic acid"] -->|"Activates"| PPARG["PPARG"]
    ACTB["ACTB"] -->|"Regulates"| PPARG["PPARG"]
    PPARA["PPARA"] -->|"Regulates"| PPARG["PPARG"]
    CAT["CAT"] -->|"Regulates"| PPARG["PPARG"]
    SQSTM1["SQSTM1"] -->|"Regulates"| PPARG["PPARG"]
    style PPARG fill:#8d4900,color:#e0e0e0
    style fat_distribution fill:#607D8B,color:#e0e0e0
    style PPARGC1A fill:#0d47a1,color:#e0e0e0
    style PPAR__ fill:#0d47a1,color:#e0e0e0
    style Metabolic_Syndrome fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Abscisic_acid fill:#00838f,color:#e0e0e0
    style ACTB fill:#8d4900,color:#e0e0e0
    style PPARA fill:#8d4900,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style SQSTM1 fill:#8d4900,color:#e0e0e0

Outgoing (655)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PPARG	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	regulates	disease	0.95
neurodegenerative disease conditions	therapeutic_target	disease	0.92
Non-Alcoholic Fatty Liver Disease	involved_in	disease	0.90
Hepatic Lipid Metabolism	regulates	process	0.90
NEURODEGENERATION	protects_against	entity	0.90
Inflammation	modulates	process	0.90
PGC1A	interacts_with	entity	0.90
KLF11	interacts_with	entity	0.85
neuroinflammation	inhibits	process	0.85
THERAPEUTIC_TARGET	associated_with	entity	0.85
Als	therapeutic_target	disease	0.85
Hematoma Resolution	promotes	process	0.85
Inflammation	regulates	disease	0.85
NFKB	modulates	gene	0.85
Intestinal Epithelial Barrier Function	regulates	process	0.85
neural stem cells	regulates	cell_type	0.80
Intestinal Inflammation	inhibits	process	0.80
neural stem cells	activates	cell_type	0.80
ZO1	upregulates	gene	0.80
Lipid Oxidation	regulates	process	0.80
MYLK	downregulates	gene	0.80
endothelial dysfunction	protects_against	phenotype	0.80
Cognitive Function	involved_in	phenotype	0.80
Cognitive Protection	involved_in	process	0.80
Thermogenesis	promotes	process	0.80
fat distribution	regulates	phenotype	0.80
Astrocyte Inflammation	inhibits	process	0.80
Microglial Inflammatory Responses	regulates	process	0.80
Neuroinflammation	inhibits	process	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
AKT	therapeutic_target	gene	0.80
inflammatory response	downregulates	process	0.79
Autoimmune	associated_with	disease	0.75
Cancer	regulates	disease	0.75
Als	associated_with	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Diabetes	therapeutic_target	disease	0.75
Alzheimer	regulates	disease	0.75
Pulmonary Arterial Hypertension	involved_in	disease	0.75
PARKINSON'S DISEASE	therapeutic_target	entity	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Atherosclerosis	therapeutic_target	disease	0.75
ALZHEIMER'S DISEASE	therapeutic_target	entity	0.75
SREBP1	regulates	entity	0.75
Neurodegeneration	regulates	disease	0.75
LC3	activates	gene	0.70

Incoming (534)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PPARG	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
Bezafibrate	activates	drug	0.95
Betulinic Acid	activates	compound	0.90
Osteoking	downregulates	drug	0.90
PI3K	therapeutic_target	gene	0.90
GW9662	inhibits	compound	0.85
PS-COOH	downregulates	compound	0.85
ASPSCR1	binds	protein	0.85
NRF2	upregulates	protein	0.85
AQP4	inhibits	protein	0.80
PPARA	associated_with	gene	0.80
AKT1	interacts_with	gene	0.80
OXIDATIVE STRESS	therapeutic_target	gene	0.80
TNF	interacts_with	gene	0.80
APOPTOSIS	activates	gene	0.80
endogenous ligands	activates	compound	0.75
rapamycin	targets	drug	0.70
TP53	therapeutic_target	gene	0.70
TNF	therapeutic_target	gene	0.70
ROS	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
ALZHEIMER	regulates	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
STAT3	interacts_with	gene	0.70
Abscisic acid	activates	drug	0.70
PPARA	interacts_with	gene	0.70
MTORC1	activates	gene	0.70
AKT1	therapeutic_target	gene	0.70
IL6	interacts_with	gene	0.70
PSEN1	interacts_with	gene	0.65
MIRNAS	expressed_in	gene	0.60
CGAS	interacts_with	gene	0.60
INS	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
LDL	activates	gene	0.60
HIF-1Α	regulates	gene	0.60
MAPK	activates	gene	0.60
APP/PS1	activates	gene	0.60
PTGS1	activates	gene	0.60
CYP1A1	activates	gene	0.60
GCN2	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
ANXA5	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPARG in their description or question text

No additional research found

PPARG

Understanding Entity Pages

Summary

Wiki Pages (6)

PPARG — Peroxisome Proliferator-Activated Receptor Gamma

PGC-1α (PPARGC1A)

PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration

PPARGC1A Gene

PPARGC1B — PPARG Coactivator 1 Beta

PPARGC1B Gene