gene

DEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

308Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DEP domain-containing mTOR interacting protein - endogenous inhibitor of mTORC1 and mTORC2 with roles in autophagy, cellular metabolism, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DEPTOR
Aliases	DEP domain-containing mTOR interacting protein
Chromosome	8q24.3
Function	is an endogenous inhibitor of both mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2.
Primary Expression	neurons and glia, where it plays important roles in regulating autophagy, synaptic plasticity, and cellular stress responses
Molecular Weight	46 kDa
Amino Acids	409 aa
Exons	11
Pathways	MTOR, mTOR, mTOR signaling
Ensembl ID	ENSG00000155792
GeneCards	DEPTOR
Human Protein Atlas	DEPTOR
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT1, AKT1S1, AMBRA1, AMPK, AND
KG Connections	308 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DEPTOR

gene · 1819 words

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Pathway Diagram

flowchart TD
    DEPTOR["DEPTOR
mTOR Inhibitor"]
    
    MTOR["MTOR
Mechanistic Target
of Rapamycin"]
    RICTOR["RICTOR
mTORC2 Component"]
    MLST8["MLST8
mTOR Complex
Component"]
    
    PI3K["PI3K/AKT
Pathway"]
    MAPK["MAPK
Signaling"]
    
    AUTOPHAGY["Autophagy
Pathway"]
    FIP200["FIP200
Autophagy
Initiator"]
    AMBRA1["AMBRA1
Autophagy
Regulator"]
    PIK3C3["PIK3C3
Autophagy
Kinase"]
    
    OXPHOS["Oxidative
Phosphorylation"]
    HSPA5["HSPA5
ER Stress
Response"]
    
    ALS["ALS
Motor Neuron
Disease"]
    MS["Multiple
Sclerosis"]
    FIBROSIS["Fibrosis"]
    
    NEURODEGENERATION["Neurodegeneration"]
    
    DEPTOR -->|"inhibits"| MTOR
    DEPTOR -->|"interacts"| RICTOR
    DEPTOR -->|"interacts"| MLST8
    
    MTOR -->|"regulates"| PI3K
    MTOR -->|"controls"| MAPK
    MTOR -->|"inhibits"| AUTOPHAGY
    
    AUTOPHAGY -->|"involves"| FIP200
    AUTOPHAGY -->|"involves"| AMBRA1
    AUTOPHAGY -->|"involves"| PIK3C3
    
    MTOR -->|"regulates"| OXPHOS
    OXPHOS -->|"triggers"| HSPA5
    
    DEPTOR -->|"regulates"| ALS
    DEPTOR -->|"interacts"| MS
    DEPTOR -->|"regulates"| FIBROSIS
    
    ALS -->|"contributes"| NEURODEGENERATION
    MS -->|"contributes"| NEURODEGENERATION
    HSPA5 -->|"promotes"| NEURODEGENERATION
    
    style DEPTOR fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style FIP200 fill:#1b5e20
    style AMBRA1 fill:#1b5e20
    style PIK3C3 fill:#1b5e20
    style MTOR fill:#4a1a6b
    style RICTOR fill:#4a1a6b
    style MLST8 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style FIBROSIS fill:#ef5350
    style NEURODEGENERATION fill:#5d4400
    style HSPA5 fill:#ef5350

Outgoing (220)

Target	Relation	Type	Str
Als	interacts_with	disease	0.75
MTOR	interacts_with	gene	0.70
Mtor	interacts_with	pathway	0.70
MTORC1	interacts_with	gene	0.70
ALS	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Wnt	regulates	pathway	0.60
KLF4	regulates	gene	0.60
Akt	regulates	pathway	0.60
GCN2	activates	gene	0.60
IFN	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
ROS	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
DNA	activates	gene	0.60
LRRK2	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60

Incoming (88)

Source	Relation	Type	Str
AKT1S1	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
CANCER	phosphorylates	entity	0.60
CYP1A1	activates	gene	0.60
rapamycin	targets	drug	0.60
DDIT3	phosphorylates	entity	0.60
IFN	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AKT1	regulates	gene	0.60
NRBF2	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
CYP1A1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DEPTOR in their description or question text

No additional research found