gene

TIMM22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

21Outgoing

22Incoming

0Experiments

0Debates

Summary

TIMM22 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Heart Failure, Ms. Connected to 44 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TIMM22
Chromosome	17p13.2
Protein Family	Translocase of inner mitochondrial membrane (TIM) family
Function	is an essential component of the TIM22 complex, which mediates the insertion of carrier proteins into the mitochondrial inner membrane.
Primary Expression	Mitochondrial inner membrane
Subcellular Localization	Mitochondrial inner membrane
Molecular Weight	25 kDa
Amino Acids	227 aa
UniProt ID	Q9Y5J7
GeneCards	TIMM22
Human Protein Atlas	TIMM22
Associated Diseases	Parkinson's Disease, Mitochondrial Disorders
Interactions	BECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L
KG Connections	43 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TIMM22 — AlphaFold Q9Y5J7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TIMM22 Gene - Translocase of Inner Mitochondrial Membrane 22

gene · 1184 words

→

TIMM22 Protein

protein · 636 words

→

Pathway Diagram

graph TD
    TIMM22["TIMM22"]
    Heart_Failure{"Heart Failure"}
    TIMM22 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM22 -->|"inhibits"| Ms
    MITOPHAGY["MITOPHAGY"]
    TIMM22 -->|"inhibits"| MITOPHAGY
    HSPE1["HSPE1"]
    TIMM22 -->|"inhibits"| HSPE1
    OPA1["OPA1"]
    TIMM22 -->|"inhibits"| OPA1
    LAMP2["LAMP2"]
    TIMM22 -->|"inhibits"| LAMP2
    BNIP3L["BNIP3L"]
    TIMM22 -->|"inhibits"| BNIP3L
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    TIMM22 -->|"inhibits"| MITOCHONDRIAL_DYSFUNCTION
    SIRT1["SIRT1"]
    TIMM22 -->|"inhibits"| SIRT1
    HTRA2["HTRA2"]
    TIMM22 -->|"inhibits"| HTRA2
    PARK2["PARK2"]
    TIMM22 -->|"inhibits"| PARK2
    PINK1["PINK1"]
    TIMM22 -->|"inhibits"| PINK1
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM22
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM22
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM22
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| TIMM22
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM22
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM22
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM22
    TIMM23["TIMM23"]
    TIMM23 -->|"inhibits"| TIMM22
    MTOR["MTOR"]
    MTOR -->|"inhibits"| TIMM22
    NRF1["NRF1"]
    NRF1 -->|"inhibits"| TIMM22
    HSPD1["HSPD1"]
    HSPD1 -->|"inhibits"| TIMM22
    MFN2["MFN2"]
    MFN2 -->|"inhibits"| TIMM22
    style TIMM22 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
Mtor	inhibits	pathway	0.60
MITOPHAGY	inhibits	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60

Incoming (22)

Source	Relation	Type	Str
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIMM22 in their description or question text

No additional research found