gene

NRF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

490Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NRF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 251 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NRF1
Chromosome	5q31.1
Protein Type	Gene
Function	NRF1 is a critical transcription factor that coordinates the expression of genes involved in mitochondrial function and cellular respiration: [@srensen2020]
Primary Expression	tissues with high energy demands:
Pathways	Apoptosis, Autophagy, Chaperone, Cholesterol, Differentiation
GeneCards	NRF1
Human Protein Atlas	NRF1
Associated Diseases	Aging, Als, Alzheimer, Breast Cancer, Cancer
Known Drugs/Compounds	nicotinamide, rapamycin
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AMYLOID-BETA
KG Connections	490 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NRF1 Gene

gene · 614 words

→

Nuclear Respiratory Factor 1 (NRF1)

protein · 624 words

→

Pathway Diagram

graph TD
    NRF1["NRF1"]
    NRF1 -->|"activates"| PINK1["PINK1"]
    NRF1 -->|"activates"| PRKN["PRKN"]
    NRF1 -->|"activates"| Als["Als"]
    NRF1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    NRF1 -->|"activates"| Ms["Ms"]
    NRF1 -->|"regulates"| Alzheimer["Alzheimer"]
    NRF1 -->|"regulates"| Cancer["Cancer"]
    NRF1 -->|"regulates"| Stroke["Stroke"]
    NRF1 -->|"activates"| Fibrosis["Fibrosis"]
    PGC1A["PGC1A"] -->|"activates"| NRF1
    PPARGC1A["PPARGC1A"] -->|"activates"| NRF1
    TFAM["TFAM"] -->|"activates"| NRF1
    MFN1["MFN1"] -->|"activates"| NRF1
    DNM1L["DNM1L"] -->|"target for"| NRF1
    DRP1["DRP1"] -->|"activates"| NRF1
    JUN["JUN"] -->|"target for"| NRF1
    GENES["GENES"] -->|"target for"| NRF1
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| NRF1
    AMPK["AMPK"] -->|"regulates"| NRF1

Outgoing (335)

Target	Relation	Type	Str
Proteasome Subunits	regulates	protein	0.88
Als	activates	disease	0.85
Proteasome Subunit Genes	regulates	pathway	0.85
mitochondrial function	participates_in	pathway	0.85
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.80
GENES	regulates	gene	0.80
Als	implicated_in	disease	0.75
Cancer	regulates	disease	0.75
unfolded protein response	participates_in	pathway	0.75
Stroke	activates	disease	0.75
Inflammation	activates	disease	0.75
Cancer	activates	disease	0.75
Aging	implicated_in	disease	0.75
Neurodegeneration	activates	disease	0.75
NAD+ metabolism	participates_in	pathway	0.75
Oxidative Stress	activates	pathway	0.70
Mitophagy	regulates	pathway	0.70
DNA	activates	gene	0.70
Apoptosis	regulates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Apoptosis	activates	pathway	0.70
APOPTOSIS	activates	gene	0.70
ATP	activates	gene	0.70
CANCER	activates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
Mitochondrial Function	activates	pathway	0.70
SIRT1	regulates	gene	0.70
NRF2	regulates	gene	0.70
NRF2	activates	gene	0.70
TFAM	regulates	gene	0.70
Ms	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Senescence	regulates	disease	0.65
Huntington	interacts_with	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Als	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Parkinson	activates	disease	0.65
Aging	degrades	disease	0.65
Epilepsy	activates	disease	0.65
Huntington	activates	disease	0.65
Ataxia	activates	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Ischemia	activates	disease	0.65
Heart Failure	inhibits	disease	0.65
Neuropathy	activates	disease	0.65
Ms	regulates	disease	0.65
Stroke	regulates	disease	0.65
Fibrosis	activates	disease	0.65

Incoming (155)

Source	Relation	Type	Str
Paeoniflorin	upregulates	compound	0.95
h-4c3210de	targets_gene	hypothesis	0.90
PPARGC1A	interacts_with	gene	0.80
PGC1A	activates	protein	0.72
NEURODEGENERATIVE DISEASES	activates	gene	0.70
TFAM	activates	gene	0.70
MITOPHAGY	regulates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
PPARGC1A	activates	gene	0.70
RIP3	activates	gene	0.60
AMPK	therapeutic_target	gene	0.60
GENES	interacts_with	gene	0.60
HUNTINGTON'S DISEASE	interacts_with	gene	0.60
HUNTINGTON	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
CAT	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
EXERCISE	activates	gene	0.60
ATP	regulates	gene	0.60
AND	activates	gene	0.60
WNT	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
MFN1	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
PARKIN	activates	gene	0.60
LRRK2	activates	gene	0.60
MFN1	inhibits	gene	0.60
SENP1	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
PARKIN	regulates	gene	0.60
PRKAA1	regulates	gene	0.60
JUN	regulates	gene	0.60
SIRT1	regulates	gene	0.60
OPA1	activates	gene	0.60
FOS	activates	gene	0.60
TAU	implicated_in	gene	0.60
SQSTM1	implicated_in	gene	0.60
NFE2L1	expressed_in	gene	0.60
P62	implicated_in	gene	0.60
PPAR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRF1 in their description or question text

No additional research found