gene

SLC22A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC22A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

17Outgoing

0Incoming

0Experiments

0Debates

Summary

Carnitine/organic cation transporter involved in ergothioneine transport and neuroprotection

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🧬 Gene Info

Gene Symbol	SLC22A4
Full Name	Solute Carrier Family 22 Member 4 (OCTN1)
Chromosome	5q31.1
Function	Ergothioneine Transport: OCTN1 is the primary high-affinity transporter for ergothioneine, a potent antioxidant that cannot be synthesized by humans and must be obtained from diet (mushrooms, certain
Amino Acids	553 aa
UniProt ID	Q9H001
NCBI Gene ID	6582
Ensembl ID	ENSG00000145040
GeneCards	SLC22A4
Human Protein Atlas	SLC22A4
Antioxidant Defense	Ergothioneine scavenges reactive oxygen species (ROS) and prevents oxidative damage
Mitochondrial Protection	Preserves mitochondrial function under stress
Neuroinflammation Modulation	Reduces microglial activation and inflammatory cytokine production
Oxidative Stress	Impaired ergothioneine transport reduces antioxidant capacity
Amyloid Interactions	Ergothioneine may interact with amyloid-beta to reduce its toxicity
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	INFLAMMATION
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC22A4 — AlphaFold Q9H001 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC22A4 — Solute Carrier Family 22 Member 4 (OCTN1)

gene · 638 words

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Pathway Diagram

graph TD
    SLC22A4["SLC22A4"]
    Ischemia{"Ischemia"}
    SLC22A4 -->|"interacts with"| Ischemia
    Inflammation{"Inflammation"}
    SLC22A4 -->|"interacts with"| Inflammation
    Ms{"Ms"}
    SLC22A4 -->|"expressed in"| Ms
    SLC22A4 -->|"expressed in"| Inflammation
    TLR4["TLR4"]
    SLC22A4 -->|"expressed in"| TLR4
    EPHA4["EPHA4"]
    SLC22A4 -->|"expressed in"| EPHA4
    PRKAA2["PRKAA2"]
    SLC22A4 -->|"expressed in"| PRKAA2
    EIF2A["EIF2A"]
    SLC22A4 -->|"expressed in"| EIF2A
    INFLAMMATION["INFLAMMATION"]
    SLC22A4 -->|"interacts with"| INFLAMMATION
    Angiogenesis(["Angiogenesis"])
    SLC22A4 -->|"interacts with"| Angiogenesis
    Immune_Response(["Immune Response"])
    SLC22A4 -->|"interacts with"| Immune_Response
    SLC22A5["SLC22A5"]
    SLC22A4 -->|"associated with"| SLC22A5
    style SLC22A4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Ischemia	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Inflammation	interacts_with	disease	0.65
INFLAMMATION	interacts_with	gene	0.60
Immune Response	expressed_in	pathway	0.60
Angiogenesis	interacts_with	pathway	0.60
Immune Response	interacts_with	pathway	0.60
INFLAMMATION	expressed_in	gene	0.60
TLR4	expressed_in	gene	0.60
EPHA4	expressed_in	gene	0.60
PRKAA2	expressed_in	gene	0.60
EIF2A	expressed_in	gene	0.60
SLC22A5	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
LEF1	associated_with	gene	0.60
CCR7	associated_with	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC22A4 in their description or question text

No additional research found