concept

STRESS GRANULES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STRESS GRANULES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

180Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	STRESS GRANULES
Key Genes/Proteins	ATXN2, CLPP, ELAVL4, FMRP, G3BP1
Related Diseases	AMYOTROPHIC LATERAL SCLEROSIS, cancer, disease, Gastric Cancer, Glioma
Related Pathways	CALCIUM SIGNALING, Drug Resistance

Pathway Diagram

graph TD
    STRESS_GRANULES["STRESS GRANULES"]
    style STRESS_GRANULES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    STRESS_GRANULES -->|"involved_in"| Prostate_Cancer["Prostate Cancer"]
    STRESS_GRANULES -->|"modulates"| Senescence["Senescence"]
    STRESS_GRANULES -->|"involved_in"| TDP_43([TDP-43])
    STRESS_GRANULES -->|"mediates"| Cellular_Stress_Response["Cellular Stress Response"]
    STRESS_GRANULES -.->|"inhibits"| Protein_Translation["Protein Translation"]
    STRESS_GRANULES -->|"involved_in"| Glioma["Glioma"]
    STRESS_GRANULES -->|"component_of"| Stress_Granule_Assembly["Stress Granule Assembly"]
    STRESS_GRANULES -->|"activates"| ChaC2_Translation["ChaC2 Translation"]
    STRESS_GRANULES -->|"regulates"| mRNA_Stability["mRNA Stability"]
    PABP1_eIF4B_Complex([PABP1/eIF4B Complex]) -->|"involved_in"| STRESS_GRANULES
    Liquid_Liquid_Phase_Separation["Liquid-Liquid Phase Separation"] -->|"involved_in"| STRESS_GRANULES
    TRIM21([TRIM21]) -->|"regulates"| STRESS_GRANULES
    G3BP1([G3BP1]) -->|"mediates"| STRESS_GRANULES
    Phase_Separation["Phase Separation"] -->|"involved_in"| STRESS_GRANULES

Outgoing (81)

Target	Relation	Type	Str
TDP-43 SUMO2/3 conjugation	promotes	process	1.00
Liquid-Liquid Phase Separation	involved_in	process	0.95
Cancer Progression	associated_with	process	0.95
Mrna Translation	regulates	process	0.95
Cellular Stress Response	involved_in	process	0.95
mRNA translation	regulates	process	0.95
Protein Synthesis	regulates	process	0.95
Mrna	associated_with	compound	0.95
Senescence	modulates	process	0.95
Drug Resistance	promotes	phenotype	0.95
Prostate Cancer	involved_in	disease	0.95
TDP-43	involved_in	protein	0.95
Cellular Stress Response	mediates	process	0.90
Stress Granule Assembly	component_of	process	0.90
Prostate Cancer	promotes	disease	0.90
RNA	regulates	entity	0.90
Cellular Protection Mechanism	involved_in	mechanism	0.90
TDP-43 proteinopathy	mediates	disease	0.90
translation	inhibits	process	0.90
Cellular Damage	protects_against	phenotype	0.90
Protein Translation	inhibits	process	0.90
Glioma	associated_with	disease	0.90
ChaC2 Translation	activates	process	0.87
cancer cell survival	promotes	phenotype	0.85
Mrna Stability	regulates	mechanism	0.85
AR	modulates	receptor	0.85
mRNA Stability	regulates	mechanism	0.85
ChaC2 Translation	mediates	process	0.85
Docetaxel Resistance	promotes	phenotype	0.85
Prostate Cancer Progression	contributes_to	phenotype	0.85
Androgen Receptor	modulates	receptor	0.85
Gene Expression	regulates	mechanism	0.85
EIF2A	phosphorylates	gene	0.85
Neurodegeneration	involved_in	process	0.85
Viral Infections	implicated_in	disease	0.85
Germ Cell Development	regulates	process	0.85
CHAC2	activates	gene	0.85
Drug Resistance	contributes_to	phenotype	0.85
glioma progression	drives	phenotype	0.82
viral infections	implicated_in	disease	0.82
Mrna Transport	regulates	process	0.80
SENESCENCE	interacts_with	entity	0.80
Androgen Receptor Signaling	modulates	pathway	0.80
Androgen Deprivation Therapy Sensitivity	modulates	phenotype	0.80
TDP-43	mediates	protein	0.80
FUS	mediates	protein	0.80
Androgen Deprivation Therapy Resistance	promotes	phenotype	0.80
Cancer Cell Protection	protects_against	phenotype	0.80
ALZHEIMER'S DISEASE	associated_with	entity	0.80
PARKINSON'S DISEASE	associated_with	entity	0.80

Incoming (99)

Source	Relation	Type	Str
PABP1/eIF4B Complex	involved_in	protein	0.95
Lysosomal Damage	associated_with	phenotype	0.95
Eif4B	involved_in	protein	0.95
Liquid-Liquid Phase Separation	involved_in	mechanism	0.95
liquid-liquid phase separation	drives	process	0.95
G3BP1	associated_with	protein	0.95
TRIM21	regulates	protein	0.95
PABP1	associated_with	protein	0.95
Pabp1/Eif4B Complex	involved_in	protein	0.95
TDP43	involved_in	protein	0.93
Mutant FUS	associated_with	protein	0.92
translation initiation factors	involved_in	protein	0.91
Genetic Mutations	causes	variant	0.90
phase separation	mediates	process	0.90
Translation Initiation Factors	interacts_with	protein	0.90
HSPB8	expressed_in	protein	0.90
TRIM21	expressed_in	protein	0.90
Liquid-Liquid Phase Separation	promotes	process	0.90
G3BP1	activates	protein	0.90
Ubiquitinated G3Bp1	regulates	protein	0.90
Liquid-Liquid Phase Separation	mediates	mechanism	0.90
G3BP1	activates	protein	0.90
G3BP1	mediates	protein	0.90
Phase Separation	involved_in	process	0.90
FUS	associated_with	protein	0.90
Atxn2 Intermediate Expansions	associated_with	biomarker	0.90
TARDBP	interacts_with	protein	0.90
FUS	interacts_with	protein	0.90
G3BP1	component_of	protein	0.90
Rna-Binding Proteins	interacts_with	protein	0.85
RNA-binding Proteins	involved_in	protein	0.85
MAPT	associated_with	gene	0.85
Mycobacterium Tuberculosis	associated_with	entity	0.85
Sars-Cov-2 Orf3A	associated_with	protein	0.85
Autophagy	degrades	process	0.85
TDP-43	aggregates_with	protein	0.80
TDP-43	co_localizes	protein	0.80
TDP-43	induces_formation_of	protein	0.80
STAU2	induces_formation	protein	0.80
TIA-1	promotes	protein	0.80
TAU	associated_with	entity	0.80
TRIM21	inhibits_formation	gene	0.80
ANXA11	regulates	gene	0.80
Glioma	associated_with	disease	0.80
ATXN2	regulates	gene	0.80
TAU	interacts_with	gene	0.80
EIF4B	associated_with	gene	0.80
TRIM21	regulates	protein	0.80
autophagy	mediates_elimination	pathway	0.80
STING	regulates	gene	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Gra	0.717	neurodegeneration	How do pathological stress granules in n
Differential Ubiquitin Chain Topology Creates 'Invisible' Su	0.682	neurodegeneration	How do pathological stress granules in n

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STRESS GRANULES in their description or question text

No additional research found