gene

LONP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LONP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

311Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LONP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 213 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LONP1
Full Name	Lon Peptidase 1
Chromosome	19p13.3
Protein Type	Protease
Function	LONP1 (Lon Peptidase 1, Mitochondrial) is a nuclear-encoded mitochondrial ATP-dependent protease essential for mitochondrial protein quality control.
Primary Expression	most tissues, with high expression in metabolically active tissues including brain, heart, and muscle
Subcellular Localization	the mitochondrial matrix. Its expression can be upregulated under conditions of mitochondrial stress
Pathways	Mitochondrial Proteostasis
UniProt ID	[P36776](https://www.uniprot.org/uniprot/P36776)
Ensembl ID	ENSG00000125726
OMIM	607440
GeneCards	LONP1
Human Protein Atlas	LONP1
Associated Diseases	Aging, Als, frontotemporal dementia, Ftd, Lymphoma, Neurodegeneration
Interactions	AGING, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS, ATF3
KG Connections	311 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LONP1

gene · 904 words

→

Pathway Diagram

graph TD
    LONP1["LONP1"]
    LONP1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    LONP1 -->|"target for"| Aging["Aging"]
    LONP1 -->|"target for"| Ms["Ms"]
    LONP1 -->|"expressed in"| Carcinoma["Carcinoma"]
    LONP1 -->|"expressed in"| Tumor["Tumor"]
    LONP1 -->|"inhibits"| Heart_Failure["Heart Failure"]
    LONP1 -->|"transports"| ALS["ALS"]
    LONP1 -->|"target for"| BDNF["BDNF"]
    ELAVL2["ELAVL2"] -->|"target for"| LONP1
    C1Q["C1Q"] -->|"target for"| LONP1
    MTOR["MTOR"] -->|"target for"| LONP1
    RAB11["RAB11"] -->|"target for"| LONP1
    STX17["STX17"] -->|"target for"| LONP1
    RAB5["RAB5"] -->|"target for"| LONP1
    SNAP29["SNAP29"] -->|"target for"| LONP1
    IGF2BP1["IGF2BP1"] -->|"target for"| LONP1
    PI3K["PI3K"] -->|"target for"| LONP1
    BDNF -->|"target for"| LONP1

Outgoing (195)

Target	Relation	Type	Str
Mitochondrial Proteostasis	involved_in	process	0.85
Proteostasis	involved_in	process	0.85
mitochondrial proteostasis	regulates	process	0.85
AKR1B10	downstream_of	gene	0.80
Als	activates	disease	0.75
Aging	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	expressed_in	disease	0.65
Metabolic Syndrome	activates	disease	0.65
ALS	transports	disease	0.65
Parkinson	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Fibrosis	activates	disease	0.65
Ms	expressed_in	disease	0.65
Aging	encodes	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Hepatitis	activates	disease	0.65
Als	interacts_with	disease	0.65
Als	transports	disease	0.65
Neurodegeneration	encodes	disease	0.65
Tumor	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Lymphoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
BAX	expressed_in	gene	0.60
Igf	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60
Ras	activates	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Akt	therapeutic_target	pathway	0.60
MITOCHONDRIA	activates	gene	0.60
ROS	activates	gene	0.60
FTLD	activates	gene	0.60
ALS	activates	gene	0.60
Unfolded Protein Response	activates	pathway	0.60
Interneuron	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
SNAP29	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
GBA1	interacts_with	gene	0.60

Incoming (116)

Source	Relation	Type	Str
AKR1B10	regulates	gene	0.80
C1Q	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
ALS	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
FTLD	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
ATP	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
AND	activates	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
CLPP	causes	gene	0.60
HTRA2	causes	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	transports	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
AGING	associated_with	gene	0.60
FTD	associated_with	entity	0.60
PI3K	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
C1Q/C3	associated_with	gene	0.60
RAB11	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
STX17	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
ELAVL2	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
ACSL4	associated_with	gene	0.60
BAX	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
HK2	associated_with	gene	0.60
CLPP	activates	gene	0.60
DNM1L	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LONP1 in their description or question text

No additional research found