gene

HSPD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

220Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for HSPD1 Gene - Heat Shock Protein Family D Member 1

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🧬 Gene Info

Gene Symbol	HSPD1
Full Name	Heat Shock Protein Family D Member 1
Aliases	Page for HSPD1 Gene
Chromosome	2q33.1
Protein Type	Chaperone
Function	HSPD1/Hsp60 is a key mitochondrial chaperone
Primary Expression	all tissues with high energy requirements:
Pathways	Mitophagy
UniProt ID	P10828
NCBI Gene ID	3329
Ensembl ID	ENSG00000134375
OMIM	118190
GeneCards	HSPD1
Human Protein Atlas	HSPD1
Associated Diseases	Aging, Carcinoma
Interactions	AIFM1, AKT, AMPK, AND, APOPTOSIS, ATF3
KG Connections	220 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPD1 — AlphaFold P10828 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HSPD1 Gene - Heat Shock Protein Family D Member 1

gene · 1372 words

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Pathway Diagram

graph TD
    HSPD1["HSPD1"]
    HSPD1 -->|"activates"| Aging["Aging"]
    HSPD1 -->|"activates"| Cardiovascular["Cardiovascular"]
    HSPD1 -->|"contributes to"| Ms["Ms"]
    HSPD1 -->|"contributes to"| Cancer["Cancer"]
    HSPD1 -->|"expressed in"| Carcinoma["Carcinoma"]
    HSPD1 -->|"inhibits"| Als["Als"]
    HSPD1 -->|"inhibits"| Tumor["Tumor"]
    HSPD1 -->|"regulates"| Heart_Failure["Heart Failure"]
    MAP1LC3B["MAP1LC3B"] -.biomarker for.-> HSPD1
    CKB["CKB"] -->|"interacts"| HSPD1
    MYO7A["MYO7A"] -->|"activates"| HSPD1
    OPTN["OPTN"] -->|"activates"| HSPD1
    PARKIN["PARKIN"] -->|"activates"| HSPD1
    PINK1["PINK1"] -->|"activates"| HSPD1
    XBP1["XBP1"] -->|"activates"| HSPD1
    ATF3["ATF3"] -->|"activates"| HSPD1
    TOMM20["TOMM20"] -->|"activates"| HSPD1

Outgoing (140)

Target	Relation	Type	Str
Aging	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Tumor	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	implicated_in	disease	0.65
Carcinoma	implicated_in	disease	0.65
Cancer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Heart Failure	regulates	disease	0.65
Cancer	contributes_to	disease	0.65
Carcinoma	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Ms	contributes_to	disease	0.65
Tumor	expressed_in	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
XBP1	activates	gene	0.60
OPTN	activates	gene	0.60
MYO7A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ATF3	activates	gene	0.60
NDP52	activates	gene	0.60
PARL	activates	gene	0.60
PHB2	activates	gene	0.60
TUBB	activates	gene	0.60
cancer	activates	disease	0.60
CANCER	contributes_to	gene	0.60
Mitophagy	expressed_in	pathway	0.60
NF-ΚB	expressed_in	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
MAP1LC3	activates	gene	0.60
RAS	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
COX4I1	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
DNAJC7	expressed_in	gene	0.60
MITOCHONDRIA	activates	gene	0.60

Incoming (80)

Source	Relation	Type	Str
MAP1LC3B	biomarker_for	gene	0.80
CKB	interacts_with	gene	0.80
APOPTOSIS	expressed_in	gene	0.60
MITOPHAGY	activates	gene	0.60
ATG	activates	gene	0.60
DMSO	activates	gene	0.60
GABA	activates	gene	0.60
GFP	activates	gene	0.60
MYO7A	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
XBP1	activates	gene	0.60
ATF3	activates	gene	0.60
TOMM20	activates	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
UBIQUITIN	activates	gene	0.60
HSP60	activates	entity	0.60
OPTINEURIN	activates	gene	0.60
AKT	activates	gene	0.60
CANCER	expressed_in	gene	0.60
HSPA9	activates	gene	0.60
MITOPHAGY	expressed_in	gene	0.60
AIFM1	activates	gene	0.60
ATP5A1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CHCHD2	activates	gene	0.60
CLPP	activates	gene	0.60
FBXO7	activates	gene	0.60
LC3B	activates	gene	0.60
AMPK	interacts_with	gene	0.60
COX2	activates	gene	0.60
ATP	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
COX4I1	activates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPD1 in their description or question text

No additional research found