gene

HTRA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTRA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

265Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HTRA2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, inhibits, associated with. Associated with Als, Heart Failure, Hepatitis. Connected to 147 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HTRA2
Full Name	HtrA Serine Peptidase 2
Aliases	HtrA2 / Omi
Chromosome	2p13.1
Protein Type	Protease
Function	is a nuclear-encoded mitochondrial serine protease that plays critical roles in cellular protein quality control and apoptosis regulation[@ncbi].
Primary Expression	regions vulnerable to neurodegenerative processes[@strauss2005]:
Subcellular Localization	Mitochondrial intermembrane space
Molecular Weight	48 kDa
Amino Acids	458 aa
Exons	8
Pathways	Autophagy, Cholesterol, Oxidative Stress
UniProt ID	O43464
NCBI Gene ID	27429
Ensembl ID	ENSG00000103472
OMIM	606476
GeneCards	HTRA2
Human Protein Atlas	HTRA2
Associated Diseases	Infection, Inflammation, Sepsis
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, Adiponectin, ADIPOQ, AMPK, AND, APOPTOSIS
KG Connections	265 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HTRA2 — AlphaFold O43464 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HTRA2 Gene

gene · 1289 words

→

HTRA2 Protein

protein · 2156 words

→

Pathway Diagram

graph TD
    HTRA2["HTRA2"]
    HTRA2 -->|"interacts"| Tumor["Tumor"]
    HTRA2 -->|"interacts"| Hepatitis["Hepatitis"]
    HTRA2 -->|"activates"| Als["Als"]
    HTRA2 -->|"activates"| Ms["Ms"]
    HTRA2 -->|"inhibits"| Heart_Failure["Heart Failure"]
    HTRA2 -->|"interacts"| MTOR["MTOR"]
    HTRA2 -->|"interacts"| SIRT3["SIRT3"]
    HTRA2 -->|"interacts"| PLIN2["PLIN2"]
    HTRA2 -->|"interacts"| TP53["TP53"]
    PPARA["PPARA"] -->|"interacts"| HTRA2
    ULK1["ULK1"] -->|"interacts"| HTRA2
    STX17["STX17"] -->|"interacts"| HTRA2
    SQSTM1["SQSTM1"] -->|"interacts"| HTRA2
    NOS3["NOS3"] -->|"interacts"| HTRA2
    STING1["STING1"] -->|"interacts"| HTRA2
    GLP1R["GLP1R"] -->|"interacts"| HTRA2
    SREBF1["SREBF1"] -->|"interacts"| HTRA2
    SIRT1["SIRT1"] -->|"interacts"| HTRA2
    KDM6B["KDM6B"] -->|"interacts"| HTRA2

Outgoing (156)

Target	Relation	Type	Str
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Als	activates	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Ms	activates	disease	0.65
Ms	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
Mitophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
PHAGOCYTOSIS	activates	entity	0.60
RAS	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
RUBCNL	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
Endothelial	interacts_with	cell_type	0.60
Unfolded Protein Response	inhibits	pathway	0.60
NOS3	activates	entity	0.60
NR1H3	activates	entity	0.60
P62	activates	entity	0.60
PLIN2	activates	entity	0.60
PLIN3	activates	entity	0.60
PPARA	activates	entity	0.60
PRKAA2	activates	entity	0.60
RPTOR	activates	entity	0.60
SIRT1	activates	entity	0.60
SIRT3	activates	entity	0.60
SQSTM1	activates	entity	0.60
SREBF1	activates	entity	0.60
SREBF2	activates	entity	0.60
STING1	activates	entity	0.60
STX17	activates	entity	0.60
TFEB	activates	entity	0.60
TP53	activates	entity	0.60
ULK1	activates	entity	0.60
RAS	activates	gene	0.60
RUBCNL	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60

Incoming (109)

Source	Relation	Type	Str
DMSO	activates	gene	0.60
GABA	activates	gene	0.60
GFP	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
DIABLO	activates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
ACOX1	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
CREB	interacts_with	gene	0.60
AMPK	activates	entity	0.60
ACOX1	activates	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
rapamycin	targets	drug	0.60
CALCOCO2	activates	gene	0.60
FIP200	activates	gene	0.60
GABARAP	activates	gene	0.60
GABARAPL1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTRA2 in their description or question text

No additional research found