protein

OPA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

785Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

OPA1 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 309 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	OPA1
Full Name	Optic Atrophy 1
Chromosome	3q29
Protein Type	Protein
Function	OPA1 is a nuclear-encoded mitochondrial protein that functions as a large GTPase mediating mitochondrial inner membrane fusion.
Subcellular Localization	the mitochondrial inner membrane where it mediates inner membrane fusion and maintains cristae structure. It is essentia
Molecular Weight	120kDa
Amino Acids	300 aa
Pathways	Apoptosis, Lysosomal Degradation, Mitochondrial Function, Mitophagy, Mtor
UniProt ID	O60313
NCBI Gene ID	4976
GeneCards	OPA1
Human Protein Atlas	OPA1
Associated Diseases	aging, Als, Alzheimer, Cancer
Interactions	AGING, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1
KG Connections	785 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OPA1 — AlphaFold O60313 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OPA1["OPA1"]
    OPA1 -->|"activates"| Als["Als"]
    OPA1 -->|"activates"| Cancer["Cancer"]
    OPA1 -->|"regulates"| Ms["Ms"]
    OPA1 -->|"expressed in"| Alzheimer["Alzheimer"]
    OPA1 -->|"expressed in"| Dementia["Dementia"]
    OPA1 -->|"activates"| Fibrosis["Fibrosis"]
    OPA1 -->|"activates"| Ischemia["Ischemia"]
    NRF1["NRF1"] -->|"activates"| OPA1
    PPARGC1A["PPARGC1A"] -->|"target for"| OPA1
    SIRT1["SIRT1"] -->|"target for"| OPA1
    DNM1L["DNM1L"] -->|"target for"| OPA1
    DRP1["DRP1"] -->|"activates"| OPA1
    PRKAA1["PRKAA1"] -->|"target for"| OPA1
    JUN["JUN"] -->|"target for"| OPA1
    VDAC1["VDAC1"] -->|"activates"| OPA1
    KRAS["KRAS"] -->|"activates"| OPA1

Outgoing (429)

Target	Relation	Type	Str
Mitochondrial Dynamics	involved_in	process	0.95
Mitochondrial fusion	activates	process	0.95
Mitochondrial Fusion	involved_in	process	0.90
mitochondrial dynamics	participates_in	pathway	0.90
Mitochondrial Fusion	mediates	process	0.88
Mitochondrial Fusion	promotes	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Als	activates	disease	0.85
DRP1	activates	gene	0.80
Als	expressed_in	disease	0.75
oxidative stress response	participates_in	pathway	0.70
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.70
MITOCHONDRIA	activates	gene	0.70
Differentiation	activates	pathway	0.70
Mitochondrial Function	associated_with	pathway	0.70
hippocampus	expressed_in	brain_region	0.70
Apoptosis	implicated_in	pathway	0.70
Mitophagy	activates	pathway	0.70
Mtor	activates	pathway	0.70
Ischemia	therapeutic_target	disease	0.65
Atherosclerosis	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	causes	disease	0.65
Aging	activates	disease	0.65
Cardiac	regulates	disease	0.65
ALS	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Pyroptosis	causes	disease	0.65
Aging	causes	disease	0.65
Diabetes	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Hypertension	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Ischemia	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Neuropathy	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Colorectal Cancer	activates	disease	0.65
Als	protects_against	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
MITOCHONDRIAL DYSFUNCTION	causes	phenotype	0.65
Neurodegeneration	associated_with	disease	0.65
Als	regulates	disease	0.65

Incoming (356)

Source	Relation	Type	Str
Aging	downregulates	process	0.85
TAU	downregulates	protein	0.85
PM10	downregulates	compound	0.85
Ros	cleaves	process	0.85
MFN2	inhibits	gene	0.80
MITOPHAGY	activates	gene	0.80
AMPK	inhibits	gene	0.70
APOPTOSIS	implicated_in	gene	0.70
SIRT3	activates	gene	0.70
ATP	inhibits	gene	0.70
Zn	activates	drug	0.70
MFN1	inhibits	gene	0.70
Copper	inhibits	drug	0.70
CHCHD10	regulates	gene	0.65
CHCHD10	causes	gene	0.65
NEURONS	stabilizes	cell_type	0.65
NEURONS	destabilizes	cell_type	0.65
IFN	associated_with	gene	0.60
ATP	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PYROPTOSIS	causes	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
IL-1	causes	gene	0.60
MTDNA	causes	gene	0.60
DNA	causes	gene	0.60
CGAS-STING	causes	gene	0.60
IL-18	activates	gene	0.60
IL-1	activates	gene	0.60
CYTOKINES	activates	gene	0.60
BCL-2	activates	gene	0.60
MAPK	activates	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
APP/PS1	therapeutic_target	gene	0.60
ATG	associated_with	gene	0.60
OXIDATIVE STRESS	implicated_in	gene	0.60
INFLAMMATION	regulates	gene	0.60
ROS	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
GABARAPL1	activates	gene	0.60
HSP60	activates	gene	0.60
HSPD1	activates	gene	0.60
HTRA2	activates	gene	0.60
LAMP1	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMPK	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
OPA1-Mediated Cristae Architecture Vulnerability	0.490	neurodegeneration	What determines the specificity of TDP-4

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OPA1 in their description or question text

No additional research found