gene

TIMM23

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

84Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

Page for TIMM23 — Translocase of Inner Mitochondrial Membrane 23

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🧬 Gene Info

Gene Symbol	TIMM23
Full Name	Translocase of Inner Mitochondrial Membrane 23
Chromosome	10q11.21.
Function	The TIM23 complex operates in conjunction with the TOM (Translocase of Outer Mitochondrial Membrane) complex, which recognizes and imports precursor proteins across the outer membrane.
Primary Expression	High in brain, heart, muscle, kidney
Amino Acids	222 aa
Pathways	Mitophagy
UniProt ID	O00231
NCBI Gene ID	10098
Ensembl ID	ENSG00000132268
GeneCards	TIMM23
Human Protein Atlas	TIMM23
Associated Diseases	Parkinson
Interactions	ABP, AMPK, ATG16L1, BCL2, BECN1, BNIP3
KG Connections	84 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TIMM23 — AlphaFold O00231 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TIMM23 — Translocase of Inner Mitochondrial Membrane 23

gene · 1951 words

→

TIMM23 Protein — Translocase of Inner Mitochondrial Membrane 23

protein · 1329 words

→

Pathway Diagram

graph TD
    TIMM23["TIMM23"]
    Heart_Failure{"Heart Failure"}
    TIMM23 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM23 -->|"inhibits"| Ms
    CALCOCO2["CALCOCO2"]
    TIMM23 -->|"interacts with"| CALCOCO2
    PARKIN["PARKIN"]
    TIMM23 -->|"interacts with"| PARKIN
    PRKN["PRKN"]
    TIMM23 -->|"interacts with"| PRKN
    NDP52["NDP52"]
    TIMM23 -->|"interacts with"| NDP52
    AMPK["AMPK"]
    TIMM23 -->|"interacts with"| AMPK
    HSPD1["HSPD1"]
    TIMM23 -->|"interacts with"| HSPD1
    Epigenetic(["Epigenetic"])
    TIMM23 -->|"interacts with"| Epigenetic
    Mitophagy(["Mitophagy"])
    TIMM23 -->|"regulates"| Mitophagy
    MTOR["MTOR"]
    TIMM23 -->|"inhibits"| MTOR
    NRF1["NRF1"]
    TIMM23 -->|"inhibits"| NRF1
    PTEN["PTEN"]
    PTEN -->|"interacts with"| TIMM23
    OPTN["OPTN"]
    OPTN -->|"interacts with"| TIMM23
    PINK1["PINK1"]
    PINK1 -->|"interacts with"| TIMM23
    TOMM20["TOMM20"]
    TOMM20 -->|"interacts with"| TIMM23
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM23
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM23
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM23
    TOMM20 -->|"inhibits"| TIMM23
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM23
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM23
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM23
    style TIMM23 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
Mtor	inhibits	pathway	0.60
MITOPHAGY	inhibits	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
CALCOCO2	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
HSPD1	interacts_with	gene	0.60
TMEM59	activates	gene	0.60
TOMM20	activates	gene	0.60
Parkinson	associated_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
AMPK	interacts_with	gene	0.60
Epigenetic	interacts_with	pathway	0.60
Mitophagy	regulates	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
DMSO	activates	gene	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
NLR	activates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
ABP	activates	gene	0.60
ATG16L1	activates	gene	0.60
BCL2	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CASP3	activates	gene	0.60
GAPDH	activates	gene	0.60
HTT	activates	gene	0.60
LC3	activates	gene	0.60
MFF	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
NLRX1	activates	gene	0.60
OPTN	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
PTEN	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
TOMM20	interacts_with	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
PRKN	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIMM23 in their description or question text

No additional research found