protein 964 words KG: EIF2A
Contents

EIF2α Protein

🔬 Protein Info
Gene SymbolEIF2A
Full NameEukaryotic Translation Initiation Factor 2A
Chromosome3q27.1
FunctionBinds the 40S ribosomal subunit
PathwaysAkt, Apoptosis, Er Stress, Wnt
UniProt IDQ9Y5Q3
NCBI Gene ID27185
Ensembl IDENSG00000144895
OMIM609994
GeneCardsEIF2A
Human Protein AtlasEIF2A
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsActin, AKT, AKT1, AKT1S1, ALS, ALZHEIMER
KG Connections530 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (11)

Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.97
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40

See Also (15)

ATF4 Gene
gene · KG edge: activates
ATF6 - Activating Transcription Factor 6
gene · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
APC Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: inhibits

Knowledge Graph (12 edges)

OPTN interacts_with EIF2A
CASP3 interacts_with EIF2A
AKT1 interacts_with EIF2A
CALCOCO2 interacts_with EIF2A
CGAS interacts_with EIF2A
CFTR interacts_with EIF2A
SQSTM1 interacts_with EIF2A
RPS6KB1 interacts_with EIF2A
GRB2 interacts_with EIF2A
RHEB interacts_with EIF2A

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