concept

STRESS GRANULES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STRESS GRANULES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

3Debates

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💡 Concept Info

Name	STRESS GRANULES
Key Genes/Proteins	ATXN2, CLPP, ELAVL4, FMRP, G3BP1
Related Diseases	AMYOTROPHIC LATERAL SCLEROSIS, cancer, disease, Gastric Cancer, Glioma
Related Pathways	CALCIUM SIGNALING, Drug Resistance

Pathway Diagram

graph TD
    STRESS_GRANULES["STRESS GRANULES"]
    style STRESS_GRANULES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    STRESS_GRANULES -->|"involved_in"| Prostate_Cancer["Prostate Cancer"]
    STRESS_GRANULES -->|"modulates"| Senescence["Senescence"]
    STRESS_GRANULES -->|"involved_in"| TDP_43([TDP-43])
    STRESS_GRANULES -->|"mediates"| Cellular_Stress_Response["Cellular Stress Response"]
    STRESS_GRANULES -.->|"inhibits"| Protein_Translation["Protein Translation"]
    STRESS_GRANULES -->|"involved_in"| Glioma["Glioma"]
    STRESS_GRANULES -->|"component_of"| Stress_Granule_Assembly["Stress Granule Assembly"]
    STRESS_GRANULES -->|"activates"| ChaC2_Translation["ChaC2 Translation"]
    STRESS_GRANULES -->|"regulates"| mRNA_Stability["mRNA Stability"]
    PABP1_eIF4B_Complex([PABP1/eIF4B Complex]) -->|"involved_in"| STRESS_GRANULES
    Liquid_Liquid_Phase_Separation["Liquid-Liquid Phase Separation"] -->|"involved_in"| STRESS_GRANULES
    TRIM21([TRIM21]) -->|"regulates"| STRESS_GRANULES
    G3BP1([G3BP1]) -->|"mediates"| STRESS_GRANULES
    Phase_Separation["Phase Separation"] -->|"involved_in"| STRESS_GRANULES

Outgoing (87)

Target	Relation	Type	Str
TDP-43 SUMO2/3 conjugation	promotes	process	1.00
mRNA translation	regulates	process	0.95
Protein Synthesis	regulates	process	0.95
Mrna	associated_with	compound	0.95
Senescence	modulates	process	0.95
Prostate Cancer	involved_in	disease	0.95
Cellular Stress Response	involved_in	process	0.95
Drug Resistance	promotes	phenotype	0.95
Mrna Translation	regulates	process	0.95
TDP-43	involved_in	protein	0.95
Liquid-Liquid Phase Separation	involved_in	process	0.95
Cancer Progression	associated_with	process	0.95
translation	inhibits	process	0.90
Stress Granule Assembly	component_of	process	0.90
RNA	regulates	entity	0.90
Protein Translation	inhibits	process	0.90
Cellular Protection Mechanism	involved_in	mechanism	0.90
Prostate Cancer	promotes	disease	0.90
TDP-43 proteinopathy	mediates	disease	0.90
liquid-to-solid transition	causes	mechanism	0.90
Glioma	associated_with	disease	0.90
Cellular Stress Response	mediates	process	0.90
Cellular Damage	protects_against	phenotype	0.90
ChaC2 Translation	activates	process	0.87
EIF2A	phosphorylates	gene	0.85
CHAC2	activates	gene	0.85
Drug Resistance	contributes_to	phenotype	0.85
Androgen Receptor	modulates	receptor	0.85
Prostate Cancer Progression	contributes_to	phenotype	0.85
ChaC2 Translation	mediates	process	0.85
mRNA Stability	regulates	mechanism	0.85
Gene Expression	regulates	mechanism	0.85
cancer cell survival	promotes	phenotype	0.85
Viral Infections	implicated_in	disease	0.85
Germ Cell Development	regulates	process	0.85
Neurodegeneration	involved_in	process	0.85
Docetaxel Resistance	promotes	phenotype	0.85
Mrna Stability	regulates	mechanism	0.85
AR	modulates	receptor	0.85
glioma progression	drives	phenotype	0.82
viral infections	implicated_in	disease	0.82
Androgen Receptor Signaling	modulates	pathway	0.80
Mrna Transport	regulates	process	0.80
Cancer Cell Protection	protects_against	phenotype	0.80
apoptosis	inhibits	process	0.80
Androgen Deprivation Therapy Resistance	promotes	phenotype	0.80
GLIOMA	associated_with	disease	0.80
cellular signaling pathways	regulates	pathway	0.80
PARKINSON'S DISEASE	associated_with	entity	0.80
SENESCENCE	interacts_with	entity	0.80

Incoming (101)

Source	Relation	Type	Str
Pabp1/Eif4B Complex	involved_in	protein	0.95
PABP1/eIF4B Complex	involved_in	protein	0.95
Lysosomal Damage	associated_with	phenotype	0.95
Eif4B	involved_in	protein	0.95
PABP1	associated_with	protein	0.95
liquid-liquid phase separation	drives	process	0.95
Liquid-Liquid Phase Separation	involved_in	mechanism	0.95
G3BP1	associated_with	protein	0.95
TRIM21	regulates	protein	0.95
TDP43	involved_in	protein	0.93
Mutant FUS	associated_with	protein	0.92
translation initiation factors	involved_in	protein	0.91
Ubiquitinated G3Bp1	regulates	protein	0.90
G3BP1	activates	protein	0.90
Genetic Mutations	causes	variant	0.90
Translation Initiation Factors	interacts_with	protein	0.90
HSPB8	expressed_in	protein	0.90
TRIM21	expressed_in	protein	0.90
FUS	interacts_with	protein	0.90
phase separation	mediates	process	0.90
G3BP1	mediates	protein	0.90
Liquid-Liquid Phase Separation	mediates	mechanism	0.90
G3BP1	component_of	protein	0.90
YTHDF2	localizes_to	protein	0.90
Liquid-Liquid Phase Separation	promotes	process	0.90
G3BP1	activates	protein	0.90
Phase Separation	involved_in	process	0.90
34378050	is associated with	paper	0.90
Atxn2 Intermediate Expansions	associated_with	biomarker	0.90
FUS	associated_with	protein	0.90
TARDBP	interacts_with	protein	0.90
Mycobacterium Tuberculosis	associated_with	entity	0.85
Sars-Cov-2 Orf3A	associated_with	protein	0.85
MAPT	associated_with	gene	0.85
Autophagy	degrades	process	0.85
RNA-binding Proteins	involved_in	protein	0.85
Rna-Binding Proteins	interacts_with	protein	0.85
TDP-43	co_localizes	protein	0.80
TDP-43	induces_formation_of	protein	0.80
STAU2	induces_formation	protein	0.80
TDP-43	aggregates_with	protein	0.80
TIA-1	promotes	protein	0.80
TAU	associated_with	entity	0.80
TRIM21	inhibits_formation	gene	0.80
ANXA11	regulates	gene	0.80
TAU	interacts_with	gene	0.80
autophagy	mediates_elimination	pathway	0.80
Glioma	associated_with	disease	0.80
EIF4B	associated_with	gene	0.80
TRIM21	regulates	protein	0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Gra	0.717	neurodegeneration	How do pathological stress granules in n
Differential Ubiquitin Chain Topology Creates 'Invisible' Su	0.682	neurodegeneration	How do pathological stress granules in n