gene

OMA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

0Hypotheses

0Analyses

50Outgoing

28Incoming

0Experiments

0Debates

Summary

OMA1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, regulates, therapeutic target. Associated with Cancer, Heart Failure, Ms. Connected to 51 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	OMA1
Full Name	OMA1 Metallopeptidase
Chromosome	1p36.21
Function	is a mitochondrial inner membrane metallopeptidase that plays a critical role in mitochondrial dynamics, quality control, and stress responses.
Molecular Weight	57 kDa
Amino Acids	524 aa
Pathways	Cgas-Sting, Mitophagy, cGAS-STING Pathway, cGAS-STING pathway, mitophagy
UniProt ID	[Q9Y5X4](https://www.uniprot.org/uniprot/Q9Y5X4)
Ensembl ID	ENSG00000174173
OMIM	607356
GeneCards	OMA1
Human Protein Atlas	OMA1
Associated Diseases	neurodegeneration
Interactions	AND, BECN1, BNIP3, BNIP3L, CEBPB, CGAS
KG Connections	114 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

OMA1 Gene

gene · 890 words

→

OMA1 Protein

protein · 1217 words

→

Pathway Diagram

graph TD
    OMA1["OMA1"]
    Heart_Failure{"Heart Failure"}
    OMA1 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    OMA1 -->|"inhibits"| Ms
    TIMM23["TIMM23"]
    OMA1 -->|"inhibits"| TIMM23
    MTOR["MTOR"]
    OMA1 -->|"inhibits"| MTOR
    NRF1["NRF1"]
    OMA1 -->|"inhibits"| NRF1
    HSPD1["HSPD1"]
    OMA1 -->|"inhibits"| HSPD1
    MFN2["MFN2"]
    OMA1 -->|"inhibits"| MFN2
    MFF["MFF"]
    OMA1 -->|"inhibits"| MFF
    BECN1["BECN1"]
    OMA1 -->|"inhibits"| BECN1
    LONP1["LONP1"]
    OMA1 -->|"inhibits"| LONP1
    CEBPB["CEBPB"]
    OMA1 -->|"inhibits"| CEBPB
    SPG7["SPG7"]
    OMA1 -->|"inhibits"| SPG7
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| OMA1
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| OMA1
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| OMA1
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| OMA1
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| OMA1
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| OMA1
    style OMA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
Glioblastoma Immune Escape	mediates	phenotype	0.95
Mitophagy	activates	process	0.95
PD-L1	upregulates	protein	0.95
cGAS-STING Pathway	activates	pathway	0.90
Immunosuppression	correlates_with	phenotype	0.80
MITOPHAGY	promotes	process	0.80
HSPA9	binds_to	gene	0.80
HSPA9	binds	protein	0.80
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Als	activates	disease	0.65
MITOCHONDRIAL DNA	activates	gene	0.60
DNM1L	inhibits	gene	0.60
PD-L1	activates	gene	0.60
CGAS-STING	activates	gene	0.60
PD-1	regulates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
T Cell	regulates	cell_type	0.60
AND	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNA	activates	gene	0.60
BAK1	regulates	gene	0.60
HSPA9	activates	gene	0.60
GBM	activates	gene	0.60
AND	regulates	gene	0.60
glioblastoma	inhibits	disease	0.60
glioblastoma	activates	disease	0.60
T cells	expressed_in	cell_type	0.60
glioblastoma	targets	disease	0.60
PD-L1	interacts_with	protein	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60

Incoming (28)

Source	Relation	Type	Str
DNA	activates	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
BAX	regulates	gene	0.60
OPA1	activates	gene	0.60
GBM	activates	gene	0.60
HSPA9	activates	gene	0.60
GBM	associated_with	gene	0.60
AND	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
GBM	inhibits	gene	0.60
GBM	targets	gene	0.60
HSPA9	targets	gene	0.60
P53	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
MITOPHAGY	activates	gene	0.60
CGAS-STING	activates	gene	0.60
PD-L1	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
PD-1	regulates	gene	0.60
PARKIN	regulates	gene	0.60
CGAS	activates	protein	0.50
STING	activates	gene	0.50
CGAS	associated_with	protein	0.50
HSPA9	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OMA1 in their description or question text

No additional research found