gene

MFN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

720Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

MFN2 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Alzheimer. Connected to 320 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MFN2
Aliases	Mitofusin 2
Chromosome	1p36.22
Function	Trans-tethering: HR2 domains form antiparallel complexes between adjacent mitochondria
Molecular Weight	84 kDa
Amino Acids	757 aa
Exons	17
Pathways	NF-κB, AMPK
GeneCards	MFN2
Human Protein Atlas	MFN2
PPARγ response elements	Enabling regulation by peroxisome proliferator-activated receptor gamma
FoxO1 binding sites	Allowing forkhead transcription factor regulation
NF-κB sites	Mediating inflammatory responses
AMPK-responsive elements	Enabling metabolic regulation
Associated Diseases	aging, Als, CHARCOT-MARIE-TOOTH, Charcot-Marie-Tooth Type 2A, Fibrosis, Hereditary Polyneuropathy
Known Drugs/Compounds	8015-P2, Piperine
Interactions	ABCG2, AGING, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	720 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MFN2["MFN2"]
    MFN2 -->|"regulates"| Ms["Ms"]
    MFN2 -->|"activates"| Inflammation["Inflammation"]
    MFN2 -->|"expressed in"| Hepatitis["Hepatitis"]
    MFN2 -->|"inhibits"| Cancer["Cancer"]
    MFN2 -->|"contributes to"| Als["Als"]
    MFN2 -->|"interacts"| Dementia["Dementia"]
    PGC_1_["PGC-1alpha"] -->|"regulates"| MFN2
    OPA1["OPA1"] -->|"regulates"| MFN2
    BAX["BAX"] -->|"activates"| MFN2
    DRP1["DRP1"] -->|"activates"| MFN2
    FADD["FADD"] -->|"activates"| MFN2
    NRF2["NRF2"] -->|"activates"| MFN2
    ABCG2["ABCG2"] -->|"activates"| MFN2
    ZBP1["ZBP1"] -->|"activates"| MFN2

Outgoing (483)

Target	Relation	Type	Str
Charcot-Marie-Tooth Type 2A	associated_with	disease	0.98
Mitochondrial Dynamics	involved_in	process	0.95
Mitochondrial Quality Control	involved_in	process	0.95
VIP Neurons	expressed_in	cell_type	0.95
Mitochondrial Dynamics	regulates	process	0.95
ER Tethering	regulates	process	0.95
Mitochondrial Transport	regulates	process	0.92
Alpha-Tubulin Acetylation	modulates	process	0.92
Synaptic Dynamics	regulates	process	0.90
Circadian Rhythms	regulates	process	0.90
ATAT1	interacts_with	enzyme	0.90
Sensory-Motor Neuropathy	involved_in	disease	0.90
Ciliary Gene Expression	regulates	process	0.90
Mitochondrial fusion	activates	process	0.90
Mitochondrial Fusion	regulates	process	0.90
ER-mitochondria juxtaposition	modulates	process	0.90
Hereditary Polyneuropathy	implicated_in	disease	0.90
Mitophagy	activates	pathway	0.90
Mitochondrial Fusion	mediates	process	0.88
Axonal Transport	regulates	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
mitochondrial dysfunction	contributes_to	process	0.85
mitochondrial DNA release	regulates	process	0.85
autophagy	regulates	process	0.85
Mitochondrial Fusion	promotes	process	0.85
Mitochondrial Dysfunction	contributes_to	phenotype	0.85
Mitochondrial dysfunction	protects_against	process	0.85
CROCC	regulates	gene	0.85
Als	activates	disease	0.85
SLC27A2	interacts_with	protein	0.80
Mitochondrial Dysfunction	regulates	process	0.80
mitochondrial dynamics	participates_in	pathway	0.80
MITOCHONDRIA	activates	gene	0.80
OPA1	inhibits	gene	0.80
Cancer	regulates	disease	0.75
Neurodegeneration	associated_with	process	0.75
Parkinson	activates	disease	0.75
Cardiac	activates	disease	0.75
Inflammation	activates	disease	0.75
Als	expressed_in	disease	0.75
INFLAMMATION	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
MTOR	regulates	gene	0.70
Oxidative Stress	activates	pathway	0.70
MFN1	inhibits	gene	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
SIRT3	activates	gene	0.70
UBIQUITIN	activates	gene	0.70
TFAM	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70

Incoming (237)

Source	Relation	Type	Str
8015-P2	activates	compound	0.90
DIZE	upregulates	drug	0.90
Palmitic Acid	downregulates	compound	0.90
PINK1-PRKN-dependent mitophagy	interacts_with	process	0.88
miR-17-5p	regulates	compound	0.85
Paclitaxel	downregulates	drug	0.85
SelH	regulates	gene	0.80
AMPK	interacts_with	gene	0.80
MITOPHAGY	activates	gene	0.80
PINK1	activates	gene	0.80
Piperine	targets	compound	0.75
PGC-1α	regulates	protein	0.70
APOPTOSIS	implicated_in	gene	0.70
Zn	activates	drug	0.70
PINK1	treats	gene	0.65
FIS1	associated_with	gene	0.60
CS	associated_with	gene	0.60
BNIP3	regulates	gene	0.60
BCL2	interacts_with	gene	0.60
TFEB	regulates	gene	0.60
MFN1	associated_with	gene	0.60
LC3B	interacts_with	gene	0.60
FUNDC1	expressed_in	gene	0.60
HMOX1	regulates	gene	0.60
BNIP3	interacts_with	gene	0.60
VDAC1	regulates	gene	0.60
CGAS	associated_with	gene	0.60
CSNK2A2	regulates	gene	0.60
UBC	regulates	gene	0.60
TFAM	regulates	gene	0.60
CALCINEURIN	regulates	gene	0.60
PI3K	associated_with	gene	0.60
FUNDC1	regulates	gene	0.60
PI3K	activates	gene	0.60
GJB1	causes	gene	0.60
MYC	regulates	gene	0.60
MFN1	interacts_with	gene	0.60
CGAS	inhibits	gene	0.60
SDHA	activates	gene	0.60
FIS1	activates	gene	0.60
MFF	protects_against	gene	0.60
GFAP	inhibits	gene	0.60
MFF	associated_with	gene	0.60
MFF	inhibits	gene	0.60
SIRT1	regulates	gene	0.60
DRP1	associated_with	gene	0.60
PTEN	activates	gene	0.60
MAP1LC3B	expressed_in	gene	0.60
DRP1	treats	gene	0.60
DRP1	accumulates_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction	0.644	neurodegeneration	What upstream mechanisms cause TDP-43 to
MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync	0.615	neurodegeneration	How do different organelle-specific auto

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning MFN2 in their description or question text

No additional research found

MFN2

Understanding Entity Pages

Summary

Wiki Pages (3)

mfn2

MFN2 Protein (Mitofusin 2)

Mitofusin 2 (MFN2)

Pathway Diagram

Outgoing (483)

Incoming (237)

Targeting Hypotheses (2)

Mentioning Analyses (3)

Immune atlas neuroinflammation analysis in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Mitochondrial transfer between neurons and glia

Experiments (0)

Related Papers (0)

Debates (4)

Mitochondrial transfer between neurons and glia?

Analysis question not specified

Mitochondrial transfer between astrocytes and neurons

Comprehensive analysis of immune cell subtypes in neurodegeneration: microglia s

Related Research