gene

PARK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

502Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

PARK2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with ALS, Aging, Als. Connected to 270 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARK2
Full Name	Parkin
Chromosome	6q26
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	52 kDa
Amino Acids	465 aa
Exons	12
Pathways	Apoptosis, Immune Response, Mitophagy
Ensembl ID	ENSG00000185345
GeneCards	PARK2
Human Protein Atlas	PARK2
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	levodopa, THSG
Interactions	AGING, ALS, AND, APOPTOSIS, AR, ATG5
KG Connections	502 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PARK2["PARK2
(Parkin Gene)"]
    PARKIN["PARKIN
(E3 Ubiquitin Ligase)"]
    THSG["THSG
(Therapeutic Compound)"]
    Mitophagy["Mitophagy
(Mitochondrial Clearance)"]
    Autophagy["Autophagy
(Cellular Clearance)"]
    MAP1LC3B["MAP1LC3B
(LC3B)"]
    SQSTM1["SQSTM1
(p62)"]
    DamagedMito["Damaged
Mitochondria"]
    Parkinson["Parkinson's
Disease"]
    Neurodegeneration["Neurodegeneration"]
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    MS["Multiple
Sclerosis"]
    Aging["Aging"]
    
    THSG -->|"activates"| PARK2
    PARK2 -->|"encodes"| PARKIN
    PARK2 -->|"regulates"| Mitophagy
    PARK2 -->|"activates"| Autophagy
    PARK2 -->|"activates"| MAP1LC3B
    PARK2 -->|"associated_with"| SQSTM1
    
    PARKIN -->|"ubiquitinates"| DamagedMito
    DamagedMito -->|"cleared_by"| Mitophagy
    MAP1LC3B -->|"facilitates"| Autophagy
    SQSTM1 -->|"links_to"| Autophagy
    
    PARK2 -->|"inhibits"| Parkinson
    PARK2 -->|"inhibits"| Neurodegeneration
    PARK2 -->|"regulates"| ALS
    PARK2 -->|"inhibits"| MS
    PARK2 -->|"inhibits"| Aging
    
    style PARK2 fill:#006494
    style PARKIN fill:#4a1a6b
    style THSG fill:#1b5e20
    style Mitophagy fill:#1b5e20
    style Autophagy fill:#1b5e20
    style MAP1LC3B fill:#4a1a6b
    style SQSTM1 fill:#4a1a6b
    style DamagedMito fill:#ef5350
    style Parkinson fill:#5d4400
    style Neurodegeneration fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Aging fill:#5d4400

Outgoing (309)

Target	Relation	Type	Str
Parkinson's Disease	risk_factor_for	disease	0.95
Mitophagy	mediates	process	0.95
neurodegeneration	associated_with	disease	0.90
PINK1	phosphorylates	gene	0.90
Mitophagy	promotes	process	0.90
Mitophagy	involved_in	process	0.90
PRKN	associated_with	gene	0.90
Substantia Nigra Neurodegeneration	protects_against	phenotype	0.88
Parkinson	associated_with	disease	0.85
Als	associated_with	disease	0.85
SNCA	regulates	gene	0.80
Alzheimer's disease	implicated_in	disease	0.80
Parkinson's disease	implicated_in	disease	0.80
Mitophagy	activates	pathway	0.80
Aging	inhibits	disease	0.75
Parkinson	inhibits	disease	0.75
PARKIN	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
PARKIN	encodes	protein	0.70
AUTOPHAGY	activates	gene	0.70
UBIQUITIN	associated_with	gene	0.70
mitophagy	promotes	process	0.70
Apoptosis	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Mitophagy	inhibits	pathway	0.70
Autophagy	activates	pathway	0.70
PARKINSON	inhibits	gene	0.70
PARKINSON	associated_with	gene	0.70
PARKINSON'S DISEASE	inhibits	gene	0.70
Parkinson's disease	interacts_with	disease	0.70
mitophagy	regulates	process	0.70
PARKIN	activates	gene	0.70
Parkinson	regulates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ischemia	regulates	disease	0.65
Stroke	activates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
Ischemia	associated_with	disease	0.65
Als	causes	disease	0.65
Ms	inhibits	disease	0.65
Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Parkinson	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Cancer	contributes_to	disease	0.65
Parkinson	implicated_in	disease	0.65

Incoming (193)

Source	Relation	Type	Str
PINK1	phosphorylates	gene	0.90
h-a11f71b5	targets_gene	hypothesis	0.90
MIF	inhibits	protein	0.80
MANF	binds	protein	0.80
MIDN	regulates	gene	0.80
GPCPD1	regulates	gene	0.80
PINK1	activates	gene	0.80
MITOPHAGY	activates	gene	0.80
THSG	activates	drug	0.70
PINK1	associated_with	gene	0.70
MITOPHAGY	inhibits	gene	0.70
BCL2L13	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SIRT5	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
TFEB	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RB1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
OVERVIEW	regulates	gene	0.60
PTEN	activates	gene	0.60
PARKIN	activates	gene	0.60
OPTN	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
TOMM20	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GAK	associated_with	gene	0.60
SYNJ1	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
BAD	activates	gene	0.60
BAX	activates	gene	0.60
ERK1	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflamma	0.571	Neuroinflammation	Immune atlas neuroinflammation analysis
PINK1/PARK2-LC3 Mitophagy Enhancement	0.485	Neuroinflammation	Immune atlas neuroinflammation analysis

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03