concept

IFN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IFN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1629Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

1Debates

Summary

IFN is a concept in neurodegeneration research. Key relationships include: activates, interacts with, inhibits. Associated with AD, ALI, ALS. Connected to 702 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IFN
Key Genes/Proteins	Actin, AGING, AHR, AIM2, Akt, AKT
Related Diseases	AD, aging, Aging, ALI
Related Pathways	Adaptive Immunity, Alpha-Synuclein
Linked Hypotheses	3 hypotheses

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IFN["IFN"]
    IFN -->|"inhibits"| Tumor["Tumor"]
    IFN -->|"inhibits"| Cancer["Cancer"]
    IFN -->|"interacts"| ALS["ALS"]
    IFN -->|"interacts"| Fibrosis["Fibrosis"]
    IFN -->|"activates"| Inflammation["Inflammation"]
    IFN -->|"activates"| Aging["Aging"]
    IFN -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    STING["STING"] -->|"activates"| IFN
    CGAS["CGAS"] -->|"activates"| IFN
    IRF3["IRF3"] -->|"activates"| IFN
    DNA["DNA"] -->|"activates"| IFN
    PARP1["PARP1"] -->|"inhibits"| IFN
    ROS["ROS"] -->|"interacts"| IFN
    RICTOR["RICTOR"] -->|"interacts"| IFN
    MTOR["MTOR"] -->|"interacts"| IFN
    MAP1LC3A["MAP1LC3A"] -->|"interacts"| IFN
    LC3["LC3"] -->|"interacts"| IFN

Outgoing (980)

Target	Relation	Type	Str
Autophagy	activates	pathway	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
Immune Response	activates	pathway	1.00
Infection	activates	disease	1.00
Aging	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Inflammation	activates	disease	1.00
Innate Immunity	activates	pathway	1.00
Nf-Κb	activates	pathway	1.00
Als	inhibits	disease	0.95
Als	therapeutic_target	disease	0.95
neural stem cells	activates	cell_type	0.90
unfolded protein response	participates_in	pathway	0.90
neuroinflammation	activates	disease	0.90
oxidative stress response	participates_in	pathway	0.90
microglia	activates	cell_type	0.90
cGAS-STING	participates_in	pathway	0.90
microglia	inhibits	cell_type	0.90
Toll-Like Receptor	activates	pathway	0.90
Apoptosis	activates	pathway	0.90
Mtor	activates	pathway	0.90
Carcinoma	activates	disease	0.85
Inflammation	regulates	disease	0.85
Tumor	therapeutic_target	disease	0.85
Inflammation	implicated_in	disease	0.85
Inflammation	inhibits	disease	0.85
Cancer	inhibits	disease	0.85
Neurodegeneration	activates	disease	0.85
Autoimmune	therapeutic_target	disease	0.85
neurons	expressed_in	cell_type	0.80
T cells	expressed_in	cell_type	0.80
ventriculomegaly	causes	disease	0.80
MIA	causes	gene	0.80
cGAS-STING	activates	pathway	0.80
LRRK2	interacts_with	protein	0.80
endothelial cells	expressed_in	cell_type	0.80
IFNGR	binds	protein	0.80
T cells	expresses	cell_type	0.80
AQP4	modulates	protein	0.80
stem cells	expressed_in	cell_type	0.80
NF-kB signaling	participates_in	pathway	0.80
neurons	activates	cell_type	0.80
microglia	associated_with	cell_type	0.80
Tgf-Β	activates	pathway	0.80
Apoptosis	inhibits	pathway	0.80
Immune Response	therapeutic_target	pathway	0.80
MICROGLIA	activates	gene	0.80
Tumor	inhibits	disease	0.75

Incoming (649)

Source	Relation	Type	Str
IL-6	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
GENES	activates	gene	1.00
P62	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
TNF-Α	activates	gene	1.00
CYTOKINES	activates	gene	1.00
DNA	activates	gene	1.00
TNF	activates	gene	1.00
CGAS	activates	protein	1.00
STING	activates	protein	1.00
NF-ΚB	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
CANCER	activates	gene	1.00
MICROGLIA	activates	gene	1.00
CGAS-STING	activates	gene	1.00
IRF3	activates	protein	0.94
APOPTOSIS	activates	gene	0.90
AKT	activates	gene	0.90
DNA	disrupts	gene	0.80
NFKB	interacts_with	pathway	0.80
CYTOKINES	inhibits	gene	0.80
TBK1	activates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
DNA	interacts_with	gene	0.80
CD8	activates	gene	0.80
CYTOKINES	contributes_to	gene	0.80
TLR4	activates	gene	0.80
MTORC1	activates	gene	0.80
MITOCHONDRIA	activates	gene	0.80
TNF	inhibits	gene	0.80
APOPTOSIS	inhibits	gene	0.80
ROS	activates	gene	0.80
IL-6	inhibits	gene	0.80
TLR	activates	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
STAT3	activates	gene	0.70
ALS	activates	gene	0.70
BAX	activates	gene	0.70
CGAS	interacts_with	gene	0.70
ATG5	activates	gene	0.70
CCL2	activates	gene	0.70
MTOR	activates	gene	0.70
AGING	activates	gene	0.70
MAVS	activates	gene	0.70
LC3	activates	gene	0.70
DSDNA	activates	gene	0.70
STAT1	activates	gene	0.70
ASTROCYTES	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.724	neurodegeneration	How do the seven novel ALS genes functio
Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific	0.720	neurodegeneration	What determines the specificity of TDP-4
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.601	neuroinflammation	What molecular mechanisms drive the tran

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.724

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Endothelium-specific TBK1 knockdown in atherosclerosis model	validation	atherosclerosis	0.900	endothelium-specific TBK1 knoc	proposed	N/A
TBK1-PAK1IP1-PAK1 signaling pathway analysis	exploratory	atherosclerosis	0.900	endothelial cells	proposed	N/A
GSK8612 treatment in atherosclerosis model	validation	atherosclerosis	0.800	atherosclerosis mouse model	proposed	N/A
LC-MS/Western blot analysis of TBK1 in atherosclerotic arteries	exploratory	atherosclerosis	0.800	mouse and human arteries with	proposed	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediat [PMID:40660474]	Li J, Yang Y, Ge Y, Zhang X, Liu H et al	Autophagy	2026
Aberrant STING signalling promotes endothelial dysfunction and neurovascular inj [PMID:41419617]	Qin X, Chen S, Sun Y, Ma Z, Niu C et al.	Diabetologia	2026
TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128]	Mordes DA, Smeyers J	Autophagy	2026
Dynamic regulation of TBK1 lactylation shapes antiviral immune responses. [PMID:41530535]	Xie Y, Zhang Y, Peng W, Zhang L, Hu Z et	Cell Mol Immunol	2026
RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250]	Naumann M, Wierschin TM, Kretschmer S, D	Adv Sci (Weinh)	2026
BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977]	Liu Q, Zhang X, Wang L, Chen H, Wang G e	Brain	2026
Systematic Review: Porphyromonas gingivalis Outer Membrane Vesicles From Pathoge [PMID:41980468]	Li Z, Luo C, Wen P, Zou T, Jin Z et al.	Int Dent J	2026
TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128]	Mordes DA, Smeyers J	Autophagy	2026
BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977]	Liu Q, Zhang X, Wang L, Chen H, Wang G,	Brain : a journal of neurology	2026
RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250]	Naumann M, Wierschin TM, Kretschmer S, D	Advanced science (Weinheim, Ba	2026

Debates (1)

Multi-agent debates referencing this entity

The authors explicitly state that the effects of these novel genes (MATR3, CHCHD

closed · Rounds: 4 · Score: 0.71 · 2026-04-14

IFN

Understanding Entity Pages

Summary

Wiki Pages (6)

IFNAR2 — Interferon Alpha Receptor 2

IFNAR1 — Interferon Alpha Receptor 1

IFNG Gene

IFN-γ Protein

IFNAR2 Protein — Interferon Alpha Receptor 2

IFNAR1 Protein — Interferon Alpha Receptor 1