gene

TIMM9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

39Outgoing

4Incoming

0Experiments

0Debates

Summary

Translocase of Inner Mitochondrial Membrane 9 - chaperone protein essential for mitochondrial protein import

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🧬 Gene Info

Gene Symbol	TIMM9
Aliases	Translocase of Inner Mitochondrial Membrane 9
Protein Type	Chaperone
Function	is a small chaperone protein localized in the mitochondrial intermembrane space.
Subcellular Localization	the mitochondrial intermembrane space. It plays an essential role in the import and insertion of proteins into the inner
Molecular Weight	10 kDa
Amino Acids	88 aa
Pathways	Unfolded Protein Response, Mitophagy, Mtor
GeneCards	TIMM9
Human Protein Atlas	TIMM9
N-terminal targeting sequence	A cleavable presequence that directs the protein to mitochondria
Twin CX3C motif	Characteristic of the Tim family, containing four cysteine residues that form two intramolecular disulfide bonds, stabilizing the protein in the oxidative environment of the intermembrane space
Hydrophobic interaction surfaces	Regions that mediate recognition of incoming precursor proteins
3 TIMM9 subunits	Forming the core scaffold of the chaperone
3 TIMM10 subunits	Providing additional substrate-binding capacity
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	BECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L
KG Connections	43 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TIMM9

gene · 1695 words

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Pathway Diagram

graph TD
    TIMM9["TIMM9"]
    Heart_Failure{"Heart Failure"}
    TIMM9 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM9 -->|"inhibits"| Ms
    TIMM17B["TIMM17B"]
    TIMM9 -->|"inhibits"| TIMM17B
    OMA1["OMA1"]
    TIMM9 -->|"inhibits"| OMA1
    TIMM23["TIMM23"]
    TIMM9 -->|"inhibits"| TIMM23
    MTOR["MTOR"]
    TIMM9 -->|"inhibits"| MTOR
    NRF1["NRF1"]
    TIMM9 -->|"inhibits"| NRF1
    HSPD1["HSPD1"]
    TIMM9 -->|"inhibits"| HSPD1
    MFN2["MFN2"]
    TIMM9 -->|"inhibits"| MFN2
    MFF["MFF"]
    TIMM9 -->|"inhibits"| MFF
    BECN1["BECN1"]
    TIMM9 -->|"inhibits"| BECN1
    LONP1["LONP1"]
    TIMM9 -->|"inhibits"| LONP1
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM9
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM9
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM9
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| TIMM9
    style TIMM9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
Mtor	inhibits	pathway	0.60
MITOPHAGY	inhibits	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60

Incoming (4)

Source	Relation	Type	Str
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIMM9 in their description or question text

No additional research found