gene

HSPE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming
0Experiments
0Debates

Summary

Page for HSPE1 — Heat Shock Protein Family E Member 1

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🧬 Gene Info
Gene SymbolHSPE1
Full NameHeat Shock Protein Family E Member 1
Chromosome2q33.1
Protein TypeChaperone
Functionis a mitochondrial co-chaperone protein that functions as a heptameric ring complex together with HSP60 (encoded by HSPD1).
Primary ExpressionUbiquitous, high in brain
Subcellular LocalizationMitochondria (matrix)
Molecular Weight10 kDa
UniProt IDP61604
NCBI Gene ID3336
OMIM600351
GeneCardsHSPE1
Human Protein AtlasHSPE1
Associated DiseasesAlzheimer
InteractionsBECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L
KG Connections114 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: HSPE1 — AlphaFold P61604 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSPE1 — Heat Shock Protein Family E Member 1

gene · 1998 words

HSPE1 Protein

protein · 671 words

Pathway Diagram

graph TD
    HSPE1["HSPE1"] -.->|"inhibits"| Heart_Failure["Heart Failure"]
    HSPE1["HSPE1"] -.->|"inhibits"| Ms["Ms"]
    HSPE1["HSPE1"] -->|"expressed in"| Lymphoma["Lymphoma"]
    HSPE1["HSPE1"] -->|"expressed in"| Ms_1["Ms"]
    HSPE1["HSPE1"] -->|"expressed in"| Cancer["Cancer"]
    HSPE1["HSPE1"] -->|"expressed in"| Tumor["Tumor"]
    BNIP3["BNIP3"] -.->|"inhibits"| HSPE1["HSPE1"]
    VDAC1["VDAC1"] -.->|"inhibits"| HSPE1["HSPE1"]
    FUNDC1["FUNDC1"] -.->|"inhibits"| HSPE1["HSPE1"]
    TOMM20["TOMM20"] -.->|"inhibits"| HSPE1["HSPE1"]
    style HSPE1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (61)

TargetRelationTypeStr
Cancerexpressed_indisease0.65
Tumorexpressed_indisease0.65
Lymphomaexpressed_indisease0.65
Msexpressed_indisease0.65
Msinhibitsdisease0.65

Incoming (53)

SourceRelationTypeStr
ANDexpressed_ingene0.60
VDAC1inhibitsgene0.60
FUNDC1inhibitsgene0.60
TOMM20inhibitsgene0.60
NDUFS4biomarker_forgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPE1 in their description or question text

No additional research found