| Gene Symbol | EIF2AK3 |
| Full Name | Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 |
| Aliases | Page for EIF2AK3 |
| Chromosome | 2p22.2 |
| Protein Type | Kinase |
| Function | EIF2AK3 (also known as PERK or EIF2AK1) is an ER transmembrane kinase that initiates the integrated stress response (ISR). |
| Primary Expression | neurons and glia, with activation in response to ER stress |
| Subcellular Localization | the ER membrane, where it serves as a master regulator of cellular stress responses. Under normal conditions, PERK exist |
| Molecular Weight | 165 kDa |
| Amino Acids | 1448 aa |
| Pathways | APOPTOSIS, Akt, Apoptosis, Wnt |
| UniProt ID | [Q9BXJ6](https://www.uniprot.org/uniprot/Q9BXJ6) |
| Ensembl ID | ENSG00000168269 |
| OMIM | 604032 |
| GeneCards | EIF2AK3 |
| Human Protein Atlas | EIF2AK3 |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | rapamycin |
| Interactions | ABCD3, ACETYL-COA, Actin, ADSL, AKT, AKT1 |
| SciDEX Hypotheses | Oligodendrocyte Stress Response Uniformity |
| KG Connections | 855 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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