gene 579 words KG: BCL2L11
Contents

BCL2L11 Gene

🧬 Gene Info
Gene SymbolBCL2L11
Full NameBCL2 Like 11 (BIM)
Chromosome2q13
Functionis a potent pro-apoptotic BH3-only protein that belongs to the Bcl-2 family.
Primary ExpressionUbiquitous; high expression in neuronal tissues
PathwaysMAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway, autophagy pathway
UniProt IDO43521
NCBI Gene ID10018
Ensembl IDENSG00000113194
OMIM603677
GeneCardsBCL2L11
Human Protein AtlasBCL2L11
Associated DiseasesAD, ALI, Als, Alzheimer, dementia
InteractionsABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
KG Connections463 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (11)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with BCL2L11
OPTN interacts_with BCL2L11
DNM1L interacts_with BCL2L11
CANX interacts_with BCL2L11
LGALS3 interacts_with BCL2L11
CALCOCO2 interacts_with BCL2L11
G3BP1 interacts_with BCL2L11
PEX3 interacts_with BCL2L11
SQSTM1 interacts_with BCL2L11
BCL2 interacts_with BCL2L11

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