concept

FOXO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

203Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

6Experiments

0Debates

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💡 Concept Info

Name	FOXO
Key Genes/Proteins	Actin, AGING, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer, Amyotrophic Lateral Sclerosis
Related Pathways	adipogenesis, Ampk Signaling
Linked Hypotheses	4 hypotheses

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOXO["FOXO"]
    style FOXO fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FOXO -.->|"inhibits"| adipogenesis["adipogenesis"]
    FOXO -->|"mediates"| Stress_Resistance(Stress Resistance)
    FOXO -->|"mediates"| G1_phase_Cell_Cycle_Arrest["G1-phase Cell Cycle Arrest"]
    FOXO -->|"activates"| apoptosis(apoptosis)
    FOXO -->|"activates"| FAS([FAS])
    FOXO -->|"activates"| BCL2L1([BCL2L1])
    FOXO -->|"activates"| BNIP3([BNIP3])
    FOXO -->|"activates"| BCL2L11([BCL2L11])
    FOXO -->|"activates"| ALS["ALS"]
    FOXO -.->|"inhibits"| Cancer["Cancer"]
    AKT([AKT]) -.->|"inhibits"| FOXO
    n_5A["5A"] -.->|"inhibits"| FOXO
    Pi3K_Akt_Pathway["Pi3K/Akt Pathway"] -->|"regulates"| FOXO
    SIRT1([SIRT1]) -->|"interacts"| FOXO
    AMPK([AMPK]) -->|"activates"| FOXO
    SIRT3([SIRT3]) -->|"activates"| FOXO
    MITOCHONDRIAL_DNA([MITOCHONDRIAL DNA]) -->|"activates"| FOXO
    MITOCHONDRIA([MITOCHONDRIA]) -->|"activates"| FOXO
    APOPTOSIS([APOPTOSIS]) -->|"activates"| FOXO

Outgoing (144)

Target	Relation	Type	Str
adipogenesis	inhibits	pathway	0.90
Stress Resistance	mediates	phenotype	0.85
G1-phase Cell Cycle Arrest	mediates	process	0.85
FAS	activates	gene	0.80
autophagy pathway	participates_in	pathway	0.80
BCL2L11	activates	gene	0.80
BCL2L1	activates	gene	0.80
BNIP3	activates	gene	0.80
apoptosis	activates	phenotype	0.80
ubiquitin-proteasome	participates_in	pathway	0.70
Alzheimer	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Senescence	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Parkinson	activates	disease	0.65
Cancer	activates	disease	0.65
NAD+ metabolism	participates_in	pathway	0.65
unfolded protein response	participates_in	pathway	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
JNK	inhibits	gene	0.60
DR5	inhibits	gene	0.60
Apoptosis	activates	pathway	0.60
Cell Cycle	activates	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
PKM2	activates	gene	0.60
MYC	activates	gene	0.60
HK2	activates	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Actin	activates	protein	0.60
FOXO1	contributes_to	gene	0.60
FOXO4	contributes_to	gene	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
MTOR	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60

Incoming (59)

Source	Relation	Type	Str
AKT	inhibits	protein	0.90
5A	inhibits	compound	0.85
Pi3K/Akt Pathway	regulates	pathway	0.85
AKT	phosphorylates	entity	0.85
PI3K/AKT	regulates	pathway	0.85
SIRT1	interacts_with	gene	0.80
AMPK	activates	protein	0.64
APOPTOSIS	activates	gene	0.60
ERK	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
MEK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
JUN	inhibits	gene	0.60
DR5	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
FUS	inhibits	gene	0.60
TDP-43	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
SIRT3	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ULK1	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
AKT	associated_with	gene	0.60
AKT	regulates	gene	0.60
AKT	targets	gene	0.60
resveratrol	targets	drug	0.60
metformin	targets	drug	0.60
GSK3	activates	gene	0.60
GLUT1	activates	gene	0.60
MTORC1	activates	gene	0.60
AKT	activates	gene	0.60
CAMKII	activates	gene	0.60
TARDBP	therapeutic_target	gene	0.60
APOE4	activates	gene	0.60
APOE	regulates	gene	0.60
FOS	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MTOR	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MTOR	activates	gene	0.60
NF-ΚB	activates	gene	0.60
PRKAA1	activates	gene	0.60
PRKAA1/2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
FOXO3-Pioneer Factor Complex Stabilizes Heterochromatin Unde	0.700	neurodegeneration	Investigate mechanisms of epigenetic rep
FOXO3-Longevity Pathway Epigenetic Reprogramming	0.630	neurodegeneration	Epigenetic clocks and biological aging i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
Gandouling protection against brain injury in Wilson's disease via SIR	validation	Hepatolenticular degeneration	0.900	0.00	TX mice (Wilson's disease mode	proposed	N/A
Proposed experiment from debate on Epigenetic clocks and biological ag	falsification	Neurodegeneration	0.400	0.50	mouse	completed	$450,000
Exercise-BDNF-Mitophagy Biomarker Study in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo	validation	Parkinson's Disease	0.400	0.50	human	completed	$2,730,000
Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson'	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096]	Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li	Autophagy	2023	1
Fifteen-minute consultation: Therapeutic hypothermia for infants with hypoxic is [PMID:31292147]	Cawley P, Chakkarapani E	Arch Dis Child Educ Pract Ed	2020	1
Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve reg [PMID:30135423]	Sahoo PK, Lee SJ, Jaiswal PB, Alber S, K	Nat Commun	2018	1
EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. [PMID:28814570]	Yang C, Wu J, de Heus C, Grigoriev I, Li	J Cell Biol	2017	1
c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Dif [PMID:26694615]	Ishibashi R, Kozuki S, Kamakura S, Sumim	J Biol Chem	2016	1
DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperate [PMID:24652652]	Polato F, Rusconi P, Zangrossi S, Morell	J Natl Cancer Inst	2014	1
IRF4 addiction in multiple myeloma. [PMID:18568025]	Shaffer AL, Emre NC, Lamy L, Ngo VN, Wri	Nature	2008	1
Guishen-erxian decoction can improve ovarian function in rats with premature ova [PMID:40931880]	Zhong H, He Y, Wang W, Liu Y, Chen D et	Histol Histopathol	2026	0
Metabolic surgery mitigates early kidney injury in obese youth with diabetes by [PMID:41665972]	Naik AS, Alakwaa FM, Nair V, McCown PJ,	J Clin Invest	2026	0
FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by [PMID:41860561]	Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ e	Aging Cell	2026	0
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activat [PMID:41891498]	Xu J, Wan W, Mu H, Gong S, Liu Y et al.	J Biochem Mol Toxicol	2026	0
IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macr [PMID:41918304]	Ma Y, Gan S, Zheng Y, Kang X, Zhu S	Korean J Pain	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoc [PMID:40106360]	Zhang W, Li W, Du J, Yang C, Yu L, Yang	Proceedings of the National Ac	2025	0
Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic [PMID:40634825]	Wei P, Zhang X, Yan C, Sun S, Chen Z, Li	Biogerontology	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
The multifaceted impact of physical exercise on FoxO signaling pathways. [PMID:40861274]	Liu W, Meng P, Li Z, Shen Y, Meng X, Jin	Frontiers in cell and developm	2025	0
Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567]	["Porzuczek J"]	Sensors (Basel, Switzerland)	2024	0
Banxia Xiexin Decoction Prevents HT22 Cells from High Glucose-induced Neurotoxic [PMID:37608672]	["Shi Y", "Sheng P", "Guo M", "Chen K",	Current computer-aided drug de	2024	0
Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. [PMID:36252111]	Zhu D, Liu S, Huang K, Wang Z, Hu S, Li	Circulation research	2022	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FOXO in their description or question text

No additional research found

FOXO

Understanding Entity Pages

Wiki Pages (8)

FOXO Signaling Pathway in Neurodegeneration

FOXO1 Protein

FOXO4 — Forkhead Box O4

FOXO3 Protein (Forkhead Box O3)

FOXO1 Gene

FOXO3 Gene

FOXO3 Protein

FOXO6 Gene