concept

NUCLEOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUCLEOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

231Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NUCLEOPHAGY is a concept in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Als. Connected to 177 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NUCLEOPHAGY
Key Genes/Proteins	ABCD3, Actin, AGING, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    NUCLEOPHAGY["NUCLEOPHAGY"]
    NUCLEOPHAGY -->|"target for"| Ms["Ms"]
    NUCLEOPHAGY -->|"target for"| Cardiovascular["Cardiovascular"]
    NUCLEOPHAGY -->|"activates"| Als["Als"]
    NUCLEOPHAGY -->|"interacts"| Alzheimer["Alzheimer"]
    NUCLEOPHAGY -->|"interacts"| ALS["ALS"]
    NUCLEOPHAGY -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    NUCLEOPHAGY -->|"interacts"| Dementia["Dementia"]
    NUCLEOPHAGY -->|"interacts"| Parkinson["Parkinson"]
    SIRT1["SIRT1"] -->|"activates"| NUCLEOPHAGY
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| NUCLEOPHAGY
    NUCLEAR_INTEGRITY["NUCLEAR INTEGRITY"] -->|"activates"| NUCLEOPHAGY
    BCL2L11["BCL2L11"] -->|"interacts"| NUCLEOPHAGY
    DNA["DNA"] -->|"interacts"| NUCLEOPHAGY
    NIX["NIX"] -->|"interacts"| NUCLEOPHAGY
    HIF1["HIF1"] -->|"interacts"| NUCLEOPHAGY
    RB1["RB1"] -->|"interacts"| NUCLEOPHAGY
    NLRP3["NLRP3"] -->|"interacts"| NUCLEOPHAGY
    PARKINSON["PARKINSON"] -->|"interacts"| NUCLEOPHAGY

Outgoing (130)

Target	Relation	Type	Str
Organelle Quality Control	involved_in	process	0.95
Nuclear Quality Control	mediates	mechanism	0.90
nuclear quality control	involved_in	process	0.85
nuclear integrity	associated_with	biological_process	0.80
Cell Survival	involved_in	phenotype	0.75
Neurodegeneration	associated_with	disease	0.75
autoimmune disorders	implicated_in	disease	0.70
neurological injury	implicated_in	disease	0.70
cancer	implicated_in	disease	0.70
neurodegeneration	implicated_in	disease	0.70
aging	implicated_in	disease	0.70
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Ms	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Als	activates	disease	0.65
Aging	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
G3BP1	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
Apoptosis	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Cell Cycle	interacts_with	pathway	0.60

Incoming (101)

Source	Relation	Type	Str
SIRT1	regulates	protein	0.80
SIRT1	associated_with	gene	0.80
BCL2L11	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
STING1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
HIF	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NUCLEOPHAGY in their description or question text

No additional research found