Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AGING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AGING is a phenotype associated with neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with AGE_RELATED_DISEASES, ALS, ALZHEIMER. Connected to 2696 entities in the SciDEX knowledge graph.
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Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
AGING["AGING"] -->|"associated with"| MICROGLIA["MICROGLIA"]
AGING["AGING"] -->|"associated with"| Aging["Aging"]
AGING["AGING"] -->|"associated with"| Alzheimer["Alzheimer"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| AGING["AGING"]
INFLAMMATION["INFLAMMATION"] -->|"associated with"| AGING["AGING"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"causes"| AGING["AGING"]
ALZHEIMER["ALZHEIMER"] -->|"causes"| AGING["AGING"]
end
subgraph Signaling["Signaling"]
AGING["AGING"] -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
AGING["AGING"] -->|"activates"| Diabetes["Diabetes"]
AGING["AGING"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
AGING["AGING"] -->|"activates"| Inflammation["Inflammation"]
AGING["AGING"] -->|"activates"| Autophagy["Autophagy"]
AGING["AGING"] -->|"regulates"| Aging_1["Aging"]
AUTOPHAGY_2["AUTOPHAGY"] -->|"regulates"| AGING["AGING"]
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| AGING["AGING"]
end
style AGING fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEUROINFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIAL_DYSFUNCTION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Nf-Κb | activates | pathway | 1.00 |
| neurodegeneration | associated_with | phenotype | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Complement | activates | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Atherosclerosis | associated_with | disease | 1.00 |
| Immune Response | associated_with | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Heart Failure | associated_with | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Mitochondrial Function | associated_with | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Telomere | associated_with | pathway | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Telomere | associated_with | pathway | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Longevity | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Infection | associated_with | disease | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| Mitochondrial Function | associated_with | pathway | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| MTOR | inhibits | gene | 1.00 |
| MITOPHAGY | regulates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| DIABETES MELLITUS | activates | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| NF-ΚB | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | regulates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| MITOPHAGY | therapeutic_target | gene | 1.00 |
| AGING | protects_against | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| AGING | interacts_with | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| UBIQUITIN | associated_with | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| GFAP | biomarker_for | gene | 1.00 |
| SIRT1 | regulates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| AGING | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| MIRNAS | therapeutic_target | gene | 1.00 |
| P53 | therapeutic_target | gene | 1.00 |
| AGING | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| AGING | inhibits | gene | 1.00 |
| AGING | activates | gene | 1.00 |
| NEUROINFLAMMATION | regulates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-03 | 44 hypotheses Top: 0.990
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer. [PMID:41605339] | Fang W, Du J, Xu Z, Liu Q, Liu Y et al. | Crit Rev Oncol Hematol | 2026 | 0 |
| Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES an [PMID:41693749] | Deng C, He Z, Zhu X | SAGE Open Med | 2026 | 0 |
| The involvement of TNFRSF25 in age-related hearing loss. [PMID:41882185] | Roche MV, Tang PC, Yan D, De Marchena MR | Hum Genet | 2026 | 0 |
| Maternal immune activation perturbs intestinal niche through microbial glyceroph [PMID:41926285] | Chang H, Zhu X, Shen C, Xu X, Ni Y et al | Cell Rep | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning AGING in their description or question text
Score: 0.600 · Alzheimer disease · 2026-04-24
## Mechanistic Overview Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration Overlap starts f
Score: 0.600 · unknown disease · 2026-04-26
A LASSO-optimized composite score integrating plasma GFAP, S100B, NFL, soluble PDGFR-β, and claudin-5 fragments to achie
Score: 0.587 · neurodegeneration · 2026-04-04
## Mechanistic Overview TNFRSF25-Mediated Aging Exosome Pathway Inhibition starts from the claim that modulating TNFRSF2
Score: 0.560 · biomarkers · 2026-04-22
## Mechanistic Overview P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming starts from the claim that modulatin
Score: 0.510 · neurodegeneration · 2026-04-22
## Mechanistic Overview Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprotective Klotho Exp