Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CANCER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Cancer encompasses a group of diseases characterized by uncontrolled cell growth, invasion, and metastasis. In the context of neurodegenerative disease research, cancer pathways are relevant because many neuroprotective mechanisms overlap with tumor suppressor pathways. Key shared pathways include apoptosis, autophagy, DNA damage response, and cell cycle regulation. Understanding the inverse relationship between cancer and neurodegeneration informs therapeutic strategies.
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| Gene Symbol | CANCER |
| Aliases | cancer |
| Clinical validation | FDA approval of Zolgensma (onasemnogene abeparvovec) in 2019 for spinal muscular atrophy demonstrated that AAV gene therapy could achieve transformative clinical outcomes in CNS diseases[@fda] |
| Expanding pipeline | Over 200 gene therapy trials are currently targeting CNS disorders, with approximately 35% focusing on neurodegenerative diseases |
| Manufacturing advances | Improvements in producer cell lines, upstream titers, and purification technologies are reducing costs and enabling commercial scale |
| Strategic investments | Major pharmaceutical companies have invested over $15 billion in gene therapy capabilities since 2018 |
| Associated Diseases | Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety |
| Known Drugs/Compounds | CISPLATIN, CURCUMIN, DEXAMETHASONE, HB147, METFORMIN, OSIMERTINIB |
| Interactions | ABCB1, ABCD3, ABCG2, ACAT1, ACC, ACE |
| KG Connections | 7415 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Therapeutic["Therapeutic"]
CANCER["CANCER"] -->|"therapeutic target"| Cancer["Cancer"]
CANCER["CANCER"] -->|"therapeutic target"| Mtor["Mtor"]
CANCER["CANCER"] -->|"therapeutic target"| MTOR["MTOR"]
CANCER["CANCER"] -->|"therapeutic target"| AKT["AKT"]
CANCER["CANCER"] -->|"therapeutic target"| Tumor["Tumor"]
end
subgraph Signaling["Signaling"]
CANCER["CANCER"] -->|"regulates"| Angiogenesis["Angiogenesis"]
CANCER["CANCER"] -->|"activates"| Wnt["Wnt"]
CANCER["CANCER"] -->|"activates"| Mapk["Mapk"]
CANCER["CANCER"] -->|"activates"| MTOR_1["MTOR"]
STAT3["STAT3"] -->|"activates"| CANCER["CANCER"]
INFLAMMATION["INFLAMMATION"] -->|"activates"| CANCER["CANCER"]
APOPTOSIS["APOPTOSIS"] -.->|"inhibits"| CANCER["CANCER"]
AUTOPHAGY_2["AUTOPHAGY"] -->|"regulates"| CANCER["CANCER"]
end
subgraph Pathology["Pathology"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| CANCER["CANCER"]
PI3K["PI3K"] -->|"associated with"| CANCER["CANCER"]
end
style CANCER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Angiogenesis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Wnt fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mapk fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style STAT3 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| Aging | activates | disease | 1.00 |
| Wnt | activates | pathway | 1.00 |
| Mitophagy | therapeutic_target | pathway | 1.00 |
| Dna Repair | inhibits | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Angiogenesis | regulates | pathway | 1.00 |
| Lymphoma | associated_with | disease | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Cell Cycle | regulates | pathway | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Tgf-Β | activates | pathway | 1.00 |
| Dna Methylation | expressed_in | pathway | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Glycolysis | therapeutic_target | pathway | 1.00 |
| Dna Methylation | regulates | pathway | 1.00 |
| Dna Repair | regulates | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Oxidative Phosphorylation | activates | pathway | 1.00 |
| Lipid Metabolism | regulates | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Wnt | associated_with | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Ferroptosis | regulates | pathway | 1.00 |
| Nf-Κb | regulates | pathway | 1.00 |
| Innate Immunity | activates | pathway | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Oxidative Phosphorylation | regulates | pathway | 1.00 |
| Lipid Metabolism | therapeutic_target | pathway | 1.00 |
| Glycolysis | regulates | pathway | 1.00 |
| Atherosclerosis | associated_with | disease | 1.00 |
| Dna Methylation | associated_with | pathway | 1.00 |
| AGING | associated_with | gene | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Immune Response | inhibits | pathway | 1.00 |
| Epigenetic | therapeutic_target | pathway | 1.00 |
| Glycolysis | inhibits | pathway | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOPTOSIS | inhibits | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| GPX4 | therapeutic_target | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| BAX | associated_with | gene | 1.00 |
| AUTOPHAGY | inhibits | gene | 1.00 |
| MYC | inhibits | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| P62 | inhibits | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| MICRORNAS | expressed_in | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| Prostate Cancer | associated_with | disease | 1.00 |
| BCL-2 | activates | gene | 1.00 |
| AMPK | therapeutic_target | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| IL6 | activates | gene | 1.00 |
| LC3 | therapeutic_target | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| CYTOKINES | inhibits | gene | 1.00 |
| GENES | expressed_in | gene | 1.00 |
| NRF2 | therapeutic_target | gene | 1.00 |
| MYC | associated_with | gene | 1.00 |
| ideas-galectin-3-modulation-neuroprotection | describes | wiki_page | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| PI3K | associated_with | gene | 1.00 |
| DNA | associated_with | gene | 1.00 |
| AMYLOID | associated_with | gene | 1.00 |
| PTEN | associated_with | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| Hepatocellular Carcinoma | associated_with | disease | 1.00 |
| MIRNAS | associated_with | gene | 1.00 |
| PTEN | associated_with | gene | 1.00 |
| KRAS | associated_with | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| AUTOPHAGY | associated_with | pathway | 1.00 |
| Breast Cancer | associated_with | disease | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| CYTOKINES | associated_with | gene | 1.00 |
| CYTOKINES | associated_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| MIRNAS | associated_with | gene | 1.00 |
| AMYLOID | associated_with | gene | 1.00 |
| DIABETES MELLITUS | therapeutic_target | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Paraneoplastic myelopathies involve CD8+ T cell recognition | 0.450 | neuroinflammation | What are the specific pathophysiological |
| Epigenetic Silencing of Tumor Suppressor Genes in Cancer Pro | 0.438 | - | - |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CANCER in their description or question text
No additional research found