gene

MAVS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAVS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

550Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Mitochondrial Antiviral Signaling Protein - key adaptor in innate immunity and neurodegeneration

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🧬 Gene Info

Gene Symbol	MAVS
Full Name	Mitochondrial Antiviral Signaling Protein
Chromosome	20p13
Protein Type	Adaptor Protein
Function	encodes a critical adaptor protein that serves as the central hub for Rig-I-like receptor (RLR) signaling in the innate immune response.
Primary Expression	Ubiquitous (liver, heart, brain)
Amino Acids	540 aa
Pathways	NF-κB
UniProt ID	Q9Y2H9
NCBI Gene ID	57468
Ensembl ID	ENSG00000088888
OMIM	609588
GeneCards	MAVS
Human Protein Atlas	MAVS
Associated Diseases	Aging, Infection, Inflammation
Known Drugs/Compounds	rapamycin
Interactions	Actin, AGING, AKT, AKT1, AKT1S1, AMBRA1
KG Connections	550 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAVS — AlphaFold Q9Y2H9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAVS Gene

gene · 1739 words

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Pathway Diagram

flowchart TD
    MAVS["MAVS
Mitochondrial Antiviral
Signaling Protein"]
    MITO["Mitochondria
Localization"]
    INNATE["Innate Immunity
Pathway"]
    IMMUNE["Immune Response
Activation"]
    AUTOPHAGY["Autophagy
Pathway"]
    FIP200["FIP200
Autophagy Initiator"]
    AMBRA1["AMBRA1
Autophagy Regulator"]
    RIPK1["RIPK1
Cell Death Regulator"]
    HMGB1["HMGB1
Damage Signal"]
    MAPK["MAPK
Signaling"]
    MTOR["mTOR
Pathway"]
    OXPHOS["Oxidative
Phosphorylation"]
    ALS["ALS
Neurodegeneration"]
    MS["Multiple Sclerosis
Neuroinflammation"]
    NEURO_DEATH["Neuronal
Cell Death"]
    INFLAMMATION["Chronic
Neuroinflammation"]
    
    MAVS -->|"localizes to"| MITO
    MAVS -->|"regulates"| INNATE
    MAVS -->|"regulates"| IMMUNE
    MAVS -->|"activates"| AUTOPHAGY
    MAVS -->|"interacts with"| FIP200
    MAVS -->|"interacts with"| AMBRA1
    MAVS -->|"interacts with"| RIPK1
    MAVS -->|"interacts with"| HMGB1
    MAVS -->|"modulates"| MAPK
    MAVS -->|"interacts with"| MTOR
    MAVS -->|"affects"| OXPHOS
    
    INNATE -->|"contributes to"| INFLAMMATION
    IMMUNE -->|"leads to"| INFLAMMATION
    RIPK1 -->|"promotes"| NEURO_DEATH
    HMGB1 -->|"amplifies"| INFLAMMATION
    INFLAMMATION -->|"drives"| ALS
    INFLAMMATION -->|"drives"| MS
    NEURO_DEATH -->|"results in"| ALS
    
    style MAVS fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style FIP200 fill:#1b5e20
    style AMBRA1 fill:#1b5e20
    style INNATE fill:#4a1a6b
    style IMMUNE fill:#4a1a6b
    style RIPK1 fill:#4a1a6b
    style HMGB1 fill:#4a1a6b
    style MAPK fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style NEURO_DEATH fill:#ef5350
    style INFLAMMATION fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style MITO fill:#2a0e3a
    style OXPHOS fill:#2a0e3a

Outgoing (337)

Target	Relation	Type	Str
Als	activates	disease	0.95
Aging	activates	disease	0.85
Immune Response	activates	pathway	0.80
Inflammation	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
MITOCHONDRIA	expressed_in	cell_type	0.72
INFLAMMATION	therapeutic_target	gene	0.70
UBIQUITIN	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
CGAS	activates	gene	0.70
IRF3	activates	gene	0.70
TBK1	activates	gene	0.70
STING	activates	gene	0.70
IFN	activates	gene	0.70
Mitophagy	activates	pathway	0.70
Autophagy	activates	pathway	0.70
INFLAMMATION	activates	gene	0.70
Als	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Ms	activates	disease	0.65
Aging	associated_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Senescence	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Inflammation	inhibits	disease	0.65
Infection	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Glaucoma	activates	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Infection	inhibits	disease	0.65
Autoimmune	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	inhibits	disease	0.65
Infection	regulates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Inflammation	implicated_in	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Als	regulates	disease	0.65
Als	inhibits	disease	0.65

Incoming (213)

Source	Relation	Type	Str
TRIM31	associated_with	protein	0.80
M2_PROTEIN	interacts_with	protein	0.72
AUTOPHAGY	activates	gene	0.70
IRF3	activates	gene	0.60
GRB2	phosphorylates	entity	0.60
GABARAP	phosphorylates	entity	0.60
STING	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
DSDNA	activates	gene	0.60
NFKB	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AND	interacts_with	gene	0.60
ASTROCYTE	regulates	gene	0.60
AND	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
RNA	activates	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
LC3	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MFF	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAVS in their description or question text

No additional research found