gene

HMOX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HMOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

502Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

HMOX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Atherosclerosis. Connected to 258 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HMOX1
Full Name	Heme Oxygenase 1
Chromosome	22q12
Protein Type	Enzyme
Function	HMOX1 degrades heme to produce biliverdin (which is further converted to bilirubin), iron (which induces ferritin), and carbon monoxide (a signaling molecule).
Pathways	Autophagy, Chaperone, Immune Response, Mitophagy, Oxidative Stress
UniProt ID	P09601
NCBI Gene ID	3162
Ensembl ID	ENSG00000101129
OMIM	141250
GeneCards	HMOX1
Human Protein Atlas	HMOX1
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Diabetes
Known Drugs/Compounds	L. reuteri-CMVs, rapamycin
Interactions	ACHE, AKK, ALOX12, ALOX15, ALOX5, ALOXE3
KG Connections	502 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HMOX1 — AlphaFold P09601 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    NFE2L2["NFE2L2
(NRF2 gene)"] -->|"activates"| HMOX1["HMOX1
(Heme Oxygenase-1)"]
    NRF2_protein["NRF2
(protein)"] -->|"regulates"| HMOX1
    HIF1["HIF1
(pathway)"] -->|"activates"| HMOX1
    L_reuteri["L. reuteri-CMVs
(therapeutic)"] -->|"activates"| HMOX1
    
    HMOX1 -->|"inhibits"| ferroptosis["Ferroptosis
(cell death)"]
    HMOX1 -->|"inhibits"| inflammation_pheno["Neuroinflammation
(process)"]
    HMOX1 -->|"activates"| NFE2L2
    HMOX1 -->|"activates"| ALOX15["ALOX15
(lipoxygenase)"]
    HMOX1 -->|"activates"| ALOX12["ALOX12
(lipoxygenase)"]
    
    HMOX1 -->|"therapeutic_target"| MS["Multiple Sclerosis
(MS)"]
    HMOX1 -->|"therapeutic_target"| Stroke["Stroke
(cerebrovascular)"]
    HMOX1 -->|"therapeutic_target"| Ischemia["Brain Ischemia
(hypoxia)"]
    HMOX1 -->|"associated_with"| ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    HMOX1 -->|"regulates"| Aging["Neuronal Aging
(senescence)"]
    
    ferroptosis --> neurodegeneration["Neurodegeneration
(outcome)"]
    inflammation_pheno --> neurodegeneration
    MS --> neurodegeneration
    ALS --> neurodegeneration
    
    style HMOX1 fill:#006494
    style ferroptosis fill:#ef5350
    style inflammation_pheno fill:#ef5350
    style neurodegeneration fill:#5d4400
    style NFE2L2 fill:#4a1a6b
    style NRF2_protein fill:#4a1a6b
    style L_reuteri fill:#1b5e20
    style MS fill:#ef5350
    style ALS fill:#ef5350
    style Stroke fill:#ef5350
    style Ischemia fill:#ef5350
    style Aging fill:#5d4400

Outgoing (332)

Target	Relation	Type	Str
Ferroptosis	associated_with	process	0.85
Inflammation	inhibits	process	0.85
ferroptosis	promotes	process	0.82
Ferroptosis	activates	pathway	0.80
FERROPTOSIS	activates	gene	0.80
Inflammation	activates	disease	0.75
Cancer	activates	disease	0.75
Aging	regulates	disease	0.75
Oxidative Stress	protects_against	process	0.75
INFLAMMATION	activates	gene	0.70
Mapk	therapeutic_target	pathway	0.70
FERROPTOSIS	associated_with	gene	0.70
GENES	associated_with	gene	0.70
GENES	biomarker_for	gene	0.70
GENES	activates	gene	0.70
Oxidative Stress	associated_with	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
Cardiac	regulates	disease	0.65
Cardiac	activates	disease	0.65
Inflammation	regulates	disease	0.65
Liver Cancer	activates	disease	0.65
Ischemia	activates	disease	0.65
Als	associated_with	disease	0.65
Stroke	activates	disease	0.65
Tumor	activates	disease	0.65
Als	expressed_in	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Stroke	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	biomarker_for	disease	0.65
Tumor	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65

Incoming (170)

Source	Relation	Type	Str
IPA	upregulates	compound	0.95
NFE2L2	regulates	gene	0.90
NFE2L2	upregulates	gene	0.90
NRF2	regulates	protein	0.87
SBFI26	upregulates	drug	0.85
L. reuteri-CMVs	activates	drug	0.80
NFE2L2	activates	gene	0.72
KEAP1	activates	gene	0.70
GPX4	activates	gene	0.70
HIF1	activates	pathway	0.64
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
TBK1	activates	gene	0.60
BACH1	activates	gene	0.60
CD47	associated_with	gene	0.60
SERPINE1	contributes_to	gene	0.60
IGF1	contributes_to	gene	0.60
CD47	interacts_with	gene	0.60
EGFR	biomarker_for	gene	0.60
APP	inhibits	gene	0.60
BAX	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
CASP3	inhibits	gene	0.60
LYSOSOME	regulates	gene	0.60
ALOX5	activates	gene	0.60
OCLN	activates	gene	0.60
NQO1	regulates	gene	0.60
GSH	activates	gene	0.60
GFP	activates	gene	0.60
rapamycin	targets	drug	0.60
HIF	targets	gene	0.60
GENES	associated_with	gene	0.60
AKK	activates	gene	0.60
LC3B	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
GENES	biomarker_for	gene	0.60
HIF	causes	gene	0.60
HO-1	expressed_in	gene	0.60
CANCER	activates	gene	0.60
AMPK	activates	gene	0.60
RNA	activates	gene	0.60
APP/PS1	expressed_in	gene	0.60
CASP1	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60
GBA	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
P2RX7	contributes_to	gene	0.60
GBM	regulates	gene	0.60
VCAM1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

Related Research

Hypotheses and analyses mentioning HMOX1 in their description or question text

No additional research found