gene

IKBKE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IKBKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

96Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

Summary

IKBKE is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, implicated in. Associated with Infection, Inflammation, Ms. Connected to 63 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IKBKE
Full Name	Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon
Chromosome	1q31.3
Protein Type	Kinase
Function	IKBKE is a non-canonical IKK family member that phosphorylates IκB proteins and activates NF-κB signaling, but also has IκB-independent functions[@hemmings2007]:
Primary Expression	breast cancer[@hershko2004] - Tumor Survival: Promotes tumor cell survival and proliferation - Metastasis: Associated with metastatic potentia
Pathways	NF-κB, NF-κB signaling
UniProt ID	Q14164
NCBI Gene ID	9641
Ensembl ID	ENSG00000105468
OMIM	605048
GeneCards	IKBKE
Human Protein Atlas	IKBKE
IκB Phosphorylation	Phosphorylates IκBα and IκBβ, leading to NF-κB activation
IKK Complex	Can form complexes with IKKγ/NEMO for NF-κB signaling
Associated Diseases	Infection, Inflammation
Interactions	AND, ATG8, AUTOPHAGY, CALCOCO2, INFLAMMATION, MAVS
KG Connections	96 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IKBKE — AlphaFold Q14164 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IKBKE (IKKε)

gene · 604 words

→

IKKε (IKBKE) Protein

protein · 778 words

→

Pathway Diagram

graph TD
    IKBKE["IKBKE"]
    Tumor{"Tumor"}
    IKBKE -->|"inhibits"| Tumor
    Ms{"Ms"}
    IKBKE -->|"inhibits"| Ms
    Inflammation{"Inflammation"}
    IKBKE -->|"activates"| Inflammation
    NDP52["NDP52"]
    IKBKE -->|"interacts with"| NDP52
    Immune_Response(["Immune Response"])
    IKBKE -->|"inhibits"| Immune_Response
    Innate_Immunity(["Innate Immunity"])
    IKBKE -->|"inhibits"| Innate_Immunity
    MITOPHAGY["MITOPHAGY"]
    IKBKE -->|"activates"| MITOPHAGY
    ATG["ATG"]
    IKBKE -->|"associated with"| ATG
    OPA1["OPA1"]
    IKBKE -->|"associated with"| OPA1
    BNIP3L["BNIP3L"]
    IKBKE -->|"associated with"| BNIP3L
    PTEN["PTEN"]
    IKBKE -->|"associated with"| PTEN
    RIPK2["RIPK2"]
    IKBKE -->|"associated with"| RIPK2
    CALCOCO2["CALCOCO2"]
    CALCOCO2 -->|"interacts with"| IKBKE
    BCL2["BCL2"]
    BCL2 -->|"associated with"| IKBKE
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"associated with"| IKBKE
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| IKBKE
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| IKBKE
    TNF["TNF"]
    TNF -->|"associated with"| IKBKE
    FIS1["FIS1"]
    FIS1 -->|"associated with"| IKBKE
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| IKBKE
    SNAP29["SNAP29"]
    SNAP29 -->|"associated with"| IKBKE
    LC3["LC3"]
    LC3 -->|"associated with"| IKBKE
    BCL2L13["BCL2L13"]
    BCL2L13 -->|"associated with"| IKBKE
    MFF["MFF"]
    MFF -->|"associated with"| IKBKE
    style IKBKE fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (59)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Infection	implicated_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Autophagy	associated_with	pathway	0.60
TAX1BP1	activates	gene	0.60
P62	activates	gene	0.60
TBK1	activates	gene	0.60
OPTN	activates	gene	0.60
SQSTM1	activates	gene	0.60
TAX1BP1	implicated_in	gene	0.60
P62	implicated_in	gene	0.60
TBK1	implicated_in	gene	0.60
OPTN	implicated_in	gene	0.60
BCL2L13	associated_with	gene	0.60
MAVS	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
ATG8	activates	gene	0.60
SESN2	associated_with	gene	0.60
INFLAMMATION	implicated_in	gene	0.60
Immune Response	inhibits	pathway	0.60
Innate Immunity	inhibits	pathway	0.60
NDP52	interacts_with	gene	0.60
HSPA1A	regulates	gene	0.60
MAVS	activates	gene	0.60
ATG	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
Mitophagy	activates	pathway	0.60
Immune Response	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
AND	regulates	gene	0.60
GENES	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
NFKB	activates	gene	0.60
AND	activates	gene	0.60
OPA1	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
RIPK2	associated_with	gene	0.60
NR4A1	associated_with	gene	0.60
PINK1	associated_with	gene	0.60

Incoming (37)

Source	Relation	Type	Str
NFKB	activates	gene	0.60
SQSTM1	implicated_in	gene	0.60
NFKB	implicated_in	gene	0.60
ROS	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
ATG	associated_with	gene	0.60
IFN	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
MAVS	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
NLRP3	associated_with	gene	0.60
NR4A1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
RIPK2	associated_with	gene	0.60
TUFM	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
TRAF2	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MFF	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SESN2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
MAVS	associated_with	gene	0.60
NDP52	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IKBKE in their description or question text

No additional research found