gene

NFE2L2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFE2L2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

856Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

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🧬 Gene Info

Gene Symbol	NFE2L2
Full Name	Nuclear Factor Erythroid 2-Related Factor 2
Chromosome	2q31
Protein Family	bZIP transcription factor family, Cap'n'collar subfamily
Pathways	Autophagy, Chaperone, Epigenetic, Ferroptosis, Glutathione Synthesis
UniProt ID	Q16236
NCBI Gene ID	4780
Ensembl ID	ENSG00000116044
OMIM	604992
GeneCards	NFE2L2
Human Protein Atlas	NFE2L2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Cancer, Carcinoma, Hepatomegaly, Hepatoprotection
Known Drugs/Compounds	dexamethasone, Dimethyl Fumarate, Itaconate, Leucocyanidin, Ml385, Pterostilbene
Interactions	ACOX1, ACTB, Adiponectin, ADIPOQ, AGING, AKT
KG Connections	854 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFE2L2 — AlphaFold Q16236 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

gene · 1644 words

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Pathway Diagram

graph TD
    NFE2L2["NFE2L2"] -->|"Activates"| HMOX1["HMOX1"]
    NFE2L2["NFE2L2"] -->|"Regulates"| SOD["SOD"]
    NFE2L2["NFE2L2"] -->|"Regulates"| GPX["GPX"]
    NFE2L2["NFE2L2"] -->|"Regulates"| oxidative_stress["oxidative stress"]
    NFE2L2["NFE2L2"] -->|"Regulates"| antioxidant_response["antioxidant response"]
    NFE2L2["NFE2L2"] -->|"Regulates"| detoxifying_enzymes["detoxifying enzymes"]
    NFE2L2["NFE2L2"] -->|"Activates"| Cancer["Cancer"]
    NFE2L2["NFE2L2"] -->|"Activates"| Ms["Ms"]
    SQSTM1G427R["SQSTM1G427R"] -->|"Impairs"| NFE2L2["NFE2L2"]
    SQSTM1["SQSTM1"] -->|"Regulates"| NFE2L2["NFE2L2"]
    arsenic["arsenic"] -->|"Modulates"| NFE2L2["NFE2L2"]
    HACE1["HACE1"] -->|"Interacts With"| NFE2L2["NFE2L2"]
    SFN["SFN"] -->|"Activates"| NFE2L2["NFE2L2"]
    style NFE2L2 fill:#8d4900,color:#e0e0e0
    style HMOX1 fill:#8d4900,color:#e0e0e0
    style SOD fill:#0d47a1,color:#e0e0e0
    style GPX fill:#0d47a1,color:#e0e0e0
    style oxidative_stress fill:#1b5e20,color:#e0e0e0
    style antioxidant_response fill:#1b5e20,color:#e0e0e0
    style detoxifying_enzymes fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style SQSTM1G427R fill:#0d47a1,color:#e0e0e0
    style SQSTM1 fill:#0d47a1,color:#e0e0e0
    style arsenic fill:#00838f,color:#e0e0e0
    style HACE1 fill:#0d47a1,color:#e0e0e0
    style SFN fill:#00838f,color:#e0e0e0

Outgoing (503)

Target	Relation	Type	Str
Antioxidant Response	regulates	process	0.95
Microglial Activation	regulates	process	0.95
Hepatomegaly	causes	phenotype	0.94
Inflammation	inhibits	process	0.92
PDGF	upregulates	gene	0.91
EGF	upregulates	gene	0.91
HMOX1	regulates	gene	0.90
HO1	regulates	gene	0.90
Antioxidant Function	mediates	process	0.90
OXIDATIVE STRESS	upregulates	process	0.90
NEURODEGENERATION	protects_against	process	0.90
Ferroptosis	protects_against	process	0.90
SQSTM1	upregulates	gene	0.90
ANTIOXIDANT ENZYMES	upregulates	enzyme	0.90
PHASE-2 ENZYMES	upregulates	enzyme	0.90
Are	component_of	pathway	0.90
Antioxidant Response	activates	pathway	0.90
Anti-Oxidative Stress Response	activates	pathway	0.90
Nerve Function Recovery	promotes	process	0.90
Antioxidant Defense	mediates	process	0.90
SLC7A11	upregulates	gene	0.90
Spinal Cord Injury	targets	disease	0.90
GPX4	upregulates	gene	0.90
HMOX1	upregulates	gene	0.90
Autophagy	activates	pathway	0.90
ACOD1	regulates	gene	0.89
Spinal Cord Injury	protects_against	disease	0.88
Lipotoxicity	protects_against	process	0.88
PI3K-AKT	upstream_of	pathway	0.85
senescence	regulates	process	0.85
Lipid Metabolism	regulates	process	0.85
Neuroprotection	mediates	process	0.85
Stress Resistance	mediates	phenotype	0.85
Mitochondrial Dysfunction	protects_against	process	0.85
Cancer	protects_against	disease	0.85
Mitochondrial Protection	mediates	process	0.85
Acute Ischemic Stroke	protects_against	disease	0.85
Glutathione Synthesis	regulates	pathway	0.85
Ferroptosis	inhibits	process	0.85
Cancer	regulates	disease	0.85
Ferroptosis	upregulates	process	0.85
antioxidant capacity	upregulates	phenotype	0.85
Remyelination	promotes	process	0.85
Iron Metabolism	regulates	process	0.85
Autophagy	mediates	process	0.85
NQO1	upregulates	gene	0.85
Neurological Dysfunction	protects_against	phenotype	0.85
HO1	upregulates	gene	0.85
Hepatic Lipid Homeostasis	mediates	process	0.85
Neuroinflammation	inhibits	process	0.85

Incoming (353)

Source	Relation	Type	Str
SQSTM1	activates	protein	1.00
KEAP1	interacts_with	protein	0.95
TGR5	activates	receptor	0.95
SESN2	regulates	gene	0.95
Itaconate	activates	compound	0.95
Leucocyanidin	activates	compound	0.95
Ric	upregulates	process	0.92
Ml385	inhibits	drug	0.92
Quercetin	activates	compound	0.90
TFEB	regulates	protein	0.90
Dimethyl Fumarate	activates	drug	0.90
LRRK2	inhibits	gene	0.90
SQSTM1	regulates	protein	0.90
SQSTM1G427R	inhibits	protein	0.90
RBX1	degrades	protein	0.90
CUL3	degrades	protein	0.90
Pterostilbene	activates	compound	0.90
Lead	promotes	drug	0.90
AUTOPHAGY	activates	gene	0.90
KEAP1	activates	gene	0.90
SQSTM1	associated_with	protein	0.88
Chronic Cerebral Hypoperfusion	downregulates	disease	0.85
SIRT3	upregulates	gene	0.85
White Matter Ischemia	associated_with	disease	0.85
superoxide	activates	protein	0.85
FYN	phosphorylates	protein	0.85
KEAP1	component_of	gene	0.85
SIRT3	activates	gene	0.85
AMPK-SIRT1 Pathway	activates	pathway	0.85
SBFI26	downregulates	drug	0.80
PRKCD	activates	gene	0.80
FERROPTOSIS	activates	gene	0.80
P62	activates	gene	0.80
NRF2	activates	gene	0.80
SFN	activates	drug	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
OXIDATIVE STRESS	causes	gene	0.70
NRF2	associated_with	gene	0.70
NRF2	regulates	gene	0.70
INFLAMMATION	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
AMPK	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
GENES	activates	gene	0.70
HACE1	interacts_with	protein	0.70
arsenic	regulates	drug	0.70
KEAP1	inhibits	protein	0.64
VDR	activates	gene	0.64
NADPH	activates	gene	0.60
MITOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFE2L2 in their description or question text

No additional research found