FERROPTOSIS
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about FERROPTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Summary
FERROPTOSIS is an entity related to neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 1915 entities in the SciDEX knowledge graph.
AI-generated illustration · click image to enlarge
Regenerate portrait ↻| Name | FERROPTOSIS |
| Key Genes/Proteins | ABCA7, ABCB1, ACC, ACETYL-COA, ACHE, ACSL4 |
| Related Diseases | Aging |
| Related Pathways | Adaptive Immunity |
Wiki Pages (1)
Knowledge base pages for this entity
Pathway Diagram
graph TD
FERROPTOSIS["FERROPTOSIS"] -->|"implicated in"| CANCER["CANCER"]
FERROPTOSIS["FERROPTOSIS"] -->|"causes"| CELL_DEATH["CELL_DEATH"]
FERROPTOSIS["FERROPTOSIS"] -->|"causes"| NECROSIS["NECROSIS"]
FERROPTOSIS["FERROPTOSIS"] -->|"associated"| CANCER_1["CANCER"]
FERROPTOSIS["FERROPTOSIS"] -->|"associated"| DSS_INDUCED_ULCERATIVE_COLITIS["DSS-INDUCED_ULCERATIVE_COLITIS"]
FERROPTOSIS["FERROPTOSIS"] -->|"activates"| Alzheimer["Alzheimer"]
AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
GPX4["GPX4"] -.->|"inhibits"| FERROPTOSIS["FERROPTOSIS"]
LIPID_PEROXIDATION["LIPID_PEROXIDATION"] -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
STING1["STING1"] -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
style FERROPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0Outgoing (2682)
| Target | Relation | Type | Str |
|---|---|---|---|
| CANCER | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Ischemia | activates | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| GENES | activates | gene | 1.00 |
| STROKE | associated_with | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| DNA | activates | gene | 1.00 |
| Hepatocellular Carcinoma | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| PYROPTOSIS | associated_with | gene | 1.00 |
| Ferroptosis | treats | pathway | 1.00 |
| Cancer | activates | disease | 1.00 |
| Ferroptosis | associated_with | pathway | 1.00 |
| Cancer | treats | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Stroke | therapeutic_target | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Ferroptosis | causes | pathway | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| Lipid Metabolism | regulates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cardiac | activates | disease | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Autophagy | activates | pathway | 1.00 |
Incoming (3935)
| Source | Relation | Type | Str |
|---|---|---|---|
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| NRF2 | regulates | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| GPX4 | regulates | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| FERROPTOSIS | associated_with | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| GPX4 | regulates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| ROS | regulates | gene | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| GENES | inhibits | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| DNA | activates | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| BECN1 | activates | gene | 1.00 |
| ROS | causes | phenotype | 1.00 |
| Cancer | activates | disease | 1.00 |
| PI3K | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| GPX4 | activates | gene | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| ACSL4 | activates | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| ROS | activates | phenotype | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| P53 | regulates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| GPX4 | inhibits | protein | 1.00 |
| P62 | activates | gene | 1.00 |
Targeting Hypotheses (25)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (7)
Scientific analyses that reference this entity
Is ferroptosis the primary driver of motor neuron death in ALS or an epiphenomen
neurodegeneration | 2026-04-18 | 4 hypotheses Top: 0.538
Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680
What determines the GPX4/ACSL4 balance that switches microglia from protective t
immunology | 2026-04-15 | 0 hypotheses
Why do clinical manifestations overlap despite distinct underlying etiologies in
neuroinflammation | 2026-04-08 | 0 hypotheses
Gene expression changes in aging mouse brain predicting neurodegenerative vulner
neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.914
Experiments (8)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice | validation | Alzheimer's disease | 0.900 | 0.00 | 5xFAD transgenic mice | proposed | N/A |
| Transcriptomic profiling and differential expression analysis | exploratory | Alzheimer's disease | 0.900 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| Irisin effects on osteogenic differentiation in mesenchymal stem cells | exploratory | bone fracture | 0.900 | 0.00 | mouse bone mesenchymal stem ce | proposed | N/A |
| SIRPα modulation in mouse models of Alzheimer's disease | validation | Alzheimer's disease | 0.900 | 0.00 | mouse models of Alzheimer's di | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| bEV isolation and LPS quantification from human samples | clinical | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
| Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat | in_vivo | post-cardiac-arrest neurodegen | 0.768 | 0.72 | Sprague-Dawley rat asphyxial c | proposed | $48,000 |
Related Papers (20)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445] | Qin J, Ma S, Wang J, Huang S, Luan J, He | Cell death & disease | 2026 | 0 |
| Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795] | Gao C, Liu B, Zhang R, Tian J, Xin H | Toxicology mechanisms and meth | 2026 | 0 |
| NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890] | Rao W, Huang Y, Li J, Chen Q, Sun J et a | J Stroke Cerebrovasc Dis | 2026 | 0 |
| Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] | Lin D, Li K, Kuang W, Chen Z, Zhang M | World J Mens Health | 2026 | 0 |
| Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496] | Che L, Zhu L, Zhou L, Zhou Y | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085] | Wen H, Zi Y, Liu Z, Bai Y, Lin J et al. | Cell Death Differ | 2026 | 0 |
| B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570] | Chien Y, Xia R, Zhou D, Ai Y, Wu L et al | Hepatol Commun | 2026 | 0 |
| Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462] | Tan Y, Ye H, Ge Q, Wang P, Liu Z et al. | J Magn Reson Imaging | 2026 | 0 |
| Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558] | Singh P, Rath SL | Journal of Alzheimer's disease | 2026 | 0 |
| Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334] | Song C, Wu X, Chen C, Shen B, He Y, Liu | Drug design, development and t | 2026 | 0 |
| Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914] | ["Xin R", "Zhang J", "Zhang Y", "Dai M", | Free radical biology & medicin | 2026 | 0 |
| Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086] | Wang Y, Zhang W, Zhang M, Zhu Y, Wang W, | Tissue & cell | 2026 | 0 |
| Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362] | Xu J, Sun M, Wang C, Ju P, Guan XD, Xie | International journal of ophth | 2026 | 0 |
| Aquaporin 4 knockdown alleviates traumatic brain edema and reduces neuronal axon [PMID:41967652] | Fang J, Pan X, Chen J | Neurobiol Dis | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550] | Wongjaikam S, Siengdee P, Somnus A, Govi | Neurotoxicity research | 2025 | 0 |
| Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cuta [PMID:41918944] | Paria S, Lapides R, Saravi B, Rajagopal | Frontiers in medicine | 2025 | 0 |
| Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358] | Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan | Scientific reports | 2025 | 0 |
| Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074] | ["Zha Xu", "Liu Xicheng", "Wei Mengping" | Cell metabolism | 2025 | 0 |
Debates (7)
Multi-agent debates referencing this entity
The debate highlighted compelling correlative evidence for ferroptosis markers i
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron
closed · Rounds: 5 · Score: 0.59 · 2026-04-16
While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th
closed · Rounds: 4 · Score: 0.80 · 2026-04-16
The abstract notes that clinical presentations overlap across different myelopat
closed · Rounds: 4 · Score: 0.86 · 2026-04-09
What gene expression changes in the aging mouse brain predict neurodegenerative
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
What gene expression changes in the aging mouse brain predict neurodegenerative
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Related Research
Hypotheses and analyses mentioning FERROPTOSIS in their description or question text
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen
Score: 0.801 · Alzheimer's Disease · 2026-04-05
## Mechanistic Overview ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzhe
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine
Score: 0.779 · Alzheimer's Disease · 2026-04-05
## Mechanistic Overview LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine in Disease-Asso
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie
Score: 0.779 · Alzheimer's Disease · 2026-04-05
## Mechanistic Overview ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter D
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidat
Score: 0.777 · Alzheimer's Disease · 2026-04-05
## Mechanistic Overview ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidation starts from
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Dise
Score: 0.776 · Alzheimer's Disease · 2026-04-05
## Mechanistic Overview LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Disease-Associated M
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Diseas
Score: 0.770 · Alzheimer's Disease · 2026-04-05
## Mechanistic Overview LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Mic
GPX4 reserve failure gates selective ALS motor-neuron ferroptosis
Score: 0.745 · neurodegeneration · 2026-04-26
ALS-linked proteostasis stress lowers effective GPX4 reserve in vulnerable motor neurons, allowing oxidized phospholipid
ACSL4 lipid remodeling creates ferroptosis-prone ALS membranes
Score: 0.710 · neurodegeneration · 2026-04-26
Motor neurons with ALS proteostasis stress may upregulate ACSL4/LPCAT3-dependent PUFA-phospholipid remodeling, creating
Ferroptosis Inhibition for α-Synuclein Neuroprotection
Score: 0.705 · neurodegeneration · 2026-04-04
## Molecular Mechanism and Rationale Ferroptosis represents a distinct form of regulated cell death characterized by ir
GPX4 Selenopeptide Mimetics as Neuroprotective Ferroptosis Blockade
Score: 0.680 · unknown disease · 2026-04-16
## Mechanistic Overview GPX4 Selenopeptide Mimetics as Neuroprotective Ferroptosis Blockade starts from the claim that m
Labile iron pool expansion amplifies genotype-specific ALS ferroptosis
Score: 0.664 · neurodegeneration · 2026-04-26
SOD1, TDP-43, and FUS pathology may converge on impaired iron buffering in motor neurons and glia, increasing labile iro
Liproxstatin-1 as Mechanism-Validation Tool for Ferroptosis Inhibition
Score: 0.580 · neurodegeneration · 2026-04-25
Liproxstatin-1 (Lip-1) inhibits ferroptosis upstream of GPX4 by blocking lipoxygenase-mediated lipid peroxidation, prese
ALOX15 Inhibition Combined with Selenium Augmentation for Synergistic Ferroptosi
Score: 0.580 · unknown disease · 2026-04-16
**Molecular Mechanism and Rationale** The proposed therapeutic strategy targets two critical nodes in the ferroptosis e
GCH1/BH4 Axis Stabilization for Dual Ferroptosis and Mitochondrial Protection
Score: 0.560 · unknown disease · 2026-04-16
## Mechanistic Overview GCH1/BH4 Axis Stabilization for Dual Ferroptosis and Mitochondrial Protection starts from the cl
Ferroptosis as Disease-Modifying Amplifier
Score: 0.538 · neurodegeneration · 2026-04-18
## Mechanistic Overview Ferroptosis as Disease-Modifying Amplifier starts from the claim that modulating not yet specifi