gene 978 words KG: RB1CC1
Contents

RB1CC1 Gene

🧬 Gene Info
Gene SymbolRB1CC1
AliasesFIP200
Chromosome8q11.23
Protein TypeKinase
Functionencodes a large scaffolding protein that plays essential roles in autophagy, mitophagy, cell cycle regulation, and tumor suppression.
Molecular Weight200 kDa
Amino Acids894 aa
PathwaysAkt, Apoptosis, Autophagy, Car-T, Immunotherapy
UniProt IDQ8TDW5
NCBI Gene ID9821
Ensembl IDENSG00000051596
OMIM606082
GeneCardsRB1CC1
Human Protein AtlasRB1CC1
Associated DiseasesAD, ALI, Als, Alzheimer, cancer
Known Drugs/Compoundsrapamycin
InteractionsABCD3, ACAT1, Actin, AKT1, AKT1S1, ALS
KG Connections1183 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (12)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
Phase-Separated Organelle Targeting
Score: 0.73

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with RB1CC1
OPTN interacts_with RB1CC1
DNM1L interacts_with RB1CC1
CANX interacts_with RB1CC1
LGALS3 interacts_with RB1CC1
CALCOCO2 interacts_with RB1CC1
G3BP1 interacts_with RB1CC1
PEX3 interacts_with RB1CC1
SQSTM1 interacts_with RB1CC1
BCL2 interacts_with RB1CC1

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